Clinical trials · California
Cognition clinical trials in California
We’re tracking 124 recruiting cognition studies with a site in California — including Phase 1/Phase 2, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT07167719Recruiting
Resilience training for parolees with adjustment challenges
This study tests a cognitive-behavioral training program to help people on parole build resilience and cope with adjustment difficulties. If you are recently on parole and having trouble adjusting, this program may offer tools to support your mental health.
Los Angeles, CaliforniaAges 18 years+ - NCT07042074Enrolling by invitation
Virtual reality for needle fear in teens
This trial tests if using augmented reality or virtual reality during talk therapy helps teenagers ages 11 to 17 who are afraid of needles. The goal is to see if these technologies can make therapy more effective and less scary.
Stanford, CaliforniaAges 11–17 - NCT05968703Recruiting
Deep brain stimulation study for mild memory trouble in Parkinson’s
This trial looks at a specific type of deep brain stimulation (DBS) to see if it can help people with Parkinson’s who have mild cognitive problems (mild memory/thinking changes). You may also be asked to temporarily stop Parkinson’s medications around research visits to measure effects more clearly.
Stanford, CaliforniaAges 21–80 - NCT06526078Recruiting
Combining brain training with ketamine for depression
This study tests if adding computer-based cognitive training to ketamine treatment can improve mood in people with depression that hasn't responded to other treatments. It aims to see if the combination works better than ketamine alone.
Oakland, CaliforniaAges 18–80 - NCT06245031Enrolling by invitation
Long-term follow-up of sensory stimulation for Alzheimer's
This is a follow-up study for people who already completed the 12-month Hope Study (CA-0011). It tests long-term safety and effects of a gentle sensory stimulation device (light and sound) for Alzheimer's disease. You will continue using the device at home with a study partner.
Costa Mesa, CaliforniaAges 50–92 - NCT06107842Recruiting
Exercise program for older veterans' memory and thinking
This study tests whether an exercise program called Gerofit can help improve memory and thinking in older Veterans. If you join, you will take part in supervised exercise sessions to see how it affects your brain health.
West Los Angeles, CaliforniaAges 65 years+ - NCT04109027Recruiting
Training program to improve thinking and memory for veterans
This trial tests an intensive skills-training program to help with thinking and memory problems after a mild-to-moderate traumatic brain injury (TBI). It’s designed for veterans who are at least 6 months past the injury and still notice cognitive symptoms that affect daily goals like work or school.
Sacramento, CaliforniaAges 21–60 - NCT05682677Recruiting
Brain stimulation plus cognitive training for depression after mild head injury
This study tests whether a combination of brain stimulation and cognitive training can reduce depression symptoms in people who have ongoing mild traumatic brain injury (TBI). It may help by targeting both mood and thinking/processing skills affected after mTBI.
La Jolla, CaliforniaAges 18–65 - NCT05620719Recruiting
Study delayed headache after head injury in veterans
This study looks at treatment for ongoing headache that starts or gets worse after a mild or moderate head/neck injury in veterans or active-duty service members. It may help by testing an approach aimed at reducing headache burden and improving daily functioning.
Los Angeles, CaliforniaAges 18–70 - NCT05254015Enrolling by invitation
Therapy for hoarding symptoms in adults 50+
This trial tests a combined therapy approach (cognitive rehabilitation plus exposure therapy) to reduce hoarding behaviors in older adults. You may benefit if your hoarding is your main diagnosis and your symptoms and medications are stable.
San Diego, CaliforniaAges 50 years+ - NCT04520139RecruitingPhase 1/Phase 2
NAC to help prevent chemo brain fog in ovarian cancer
This Phase 1/2 study tests whether taking NAC (a supplement medicine) can help prevent or reduce memory and thinking problems after platinum chemotherapy. It targets people with advanced ovarian, fallopian tube, or primary peritoneal cancer who are starting at least six cycles of platinum-based treatment.
Orange, CaliforniaAges 18 years+ - NCT04297020Recruiting
Checking brain health in breast cancer survivors
This study looks at differences in brain function in people who have had breast cancer, compared with certain people without that history. It’s testing how brain health changes after breast cancer and relates to mood, thinking, and daily functioning.
Los Angeles, CaliforniaAges 35–65 - NCT04343157RecruitingPhase 2
Image-guided radiation for brain tumors that protects thinking
This trial tests a special type of radiation therapy for brain tumors that aims to protect your memory and thinking skills. It may be an option if you have certain brain tumors or a small number of brain metastases.
San Diego, CaliforniaAges 18 years+ - NCT04240665Enrolling by invitation
Test a digital notebook for memory problems
This study tests a digital “memory notebook” to help people who have early memory concerns keep track and report changes over time. It may be useful if you’re having mild memory issues and can complete surveys with a study partner.
Sacramento, CaliforniaAges 60 years+ - NCT07853807Recruiting
Thinking and memory study for adults with schizophrenia and healthy volunteers
This study uses computer tasks to learn how people with schizophrenia think, pay attention, and remember. It may help improve future tests and treatments for schizophrenia. Healthy volunteers are also needed to compare results.
Irvine, CaliforniaAges 18–59 - NCT03655782Recruiting
Retraining brain pathways to improve memory after mild brain injury
This study tests a computer-based brain training program that may help improve memory and thinking skills in people who have had a mild traumatic brain injury or concussion. The training involves watching moving stripes on a screen and using arrow keys to respond, which is designed to retrain brain pathways.
San Diego, CaliforniaAges 18–60 - NCT06116630Recruiting
Brain health after stroke risk factors study
This study looks at how well the brain works after a stroke or in people with stroke risk factors. It uses a special MRI scan to understand brain changes that may affect thinking and memory.
Palo Alto, CaliforniaAges 45–90 - NCT07717411RecruitingPhase 3
Trontinemab for people at risk of Alzheimer's symptoms
This study tests an investigational drug, trontinemab, in people who are cognitively healthy but have a blood marker suggesting a high chance of developing Alzheimer's symptoms later. The goal is to see if the drug can delay or prevent memory loss.
Irvine, CaliforniaAges 55–80 - NCT07673172Enrolling by invitation
Heart Health Program for Teens and Young Adults with Autism
This trial tests a two-part program to improve heart health in people with autism who are above a healthy weight. It may help you learn ways to take better care of your heart.
Los Angeles, CaliforniaAges 9–26 - NCT07663578Recruiting
Brain stimulation study for epilepsy patients and healthy volunteers
This study tests a new non-invasive brain stimulation method called TIEFS. It uses safe electric fields to see how it affects thinking and brain waves. You may join if you are having brain surgery for epilepsy or are a healthy adult.
Sacramento, CaliforniaAges 18–65 - NCT07646054Enrolling by invitation
Lifestyle coaching for preventing Alzheimer's in APOE4 carriers
This study tests a digital lifestyle coaching program designed to help prevent Alzheimer's disease in people who carry the APOE4 genetic variant, which increases risk. Over one year, you'll get personalized health coaching through apps and possibly a smart ring to track your progress.
La Jolla, CaliforniaAges 60–80 - NCT07633470RecruitingPhase 4
Zunveyl for Alzheimer's disease symptoms and caregiver support
This study tests a medication called Zunveyl to see if it helps reduce behavioral and neuropsychiatric symptoms in people with mild-to-moderate Alzheimer's disease, and whether it reduces stress on family caregivers. You would need a confirmed Alzheimer's diagnosis supported by a blood test, and a dedicated caregiver who can attend visits and report on your symptoms.
Irvine, CaliforniaAges 50 years+ - NCT07577947Recruiting
Digital tracking to help treat pregnancy and postpartum depression
This study tests whether wearing an Apple Watch and using a smartphone app can help doctors better understand and treat depression during pregnancy and after birth. You'll receive depression treatment through the study while the app and watch track your daily patterns.
Los Angeles, CaliforniaAges 18 years+ - NCT07572630Enrolling by invitation
How your brain processes visual information and attention
This research study examines how your brain focuses on and processes visual details. Participants will complete visual tasks while we monitor brain activity using safe imaging technology, helping us understand how attention shapes what we see.
Santa Barbara, CaliforniaAges 18–55
Where these studies are running in California
Institutions with a site for the recruiting cognition studies listed above.
- Syrentis Clinical Research · 2 studies
- University of California, Irvine · 2 studies
- 1100 Glendon Ave
- Advanced Research Center (ARC)
- Alzheimer's Disease Center, University of California, Davis
- ATP Clinical Research, Inc - Orange
- ATP Clinical Research, Inc.
- Guava Hall
What taking part in a cognition study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Cognition trials in other states
Common questions
- Are there cognition clinical trials in California?
- Yes. We're currently tracking 124 recruiting cognition studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cognition study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cognition trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cognition studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.