Clinical trials · California
Cognition clinical trials in California
We’re tracking 124 recruiting cognition studies with a site in California — including Phase 1/Phase 2, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT07554833Recruiting
Brain Stimulation for Parkinson's Motor and Memory Skills
This study tests whether repeated magnetic stimulation (rTMS) of the brain can help improve movement and thinking problems in people with Parkinson's disease. Researchers will measure how the treatment affects your motor control and cognitive function over the study period.
San Francisco, CaliforniaAges 50–90 - NCT07516119Recruiting
Predicting Alzheimer's Risk Before Memory Loss Occurs
This study identifies people at high risk for Alzheimer's disease before symptoms develop, using genetics and digital tools to track brain health over time. If you qualify, you'll help researchers understand who will develop cognitive decline and potentially enable earlier interventions.
San Diego, CaliforniaAges 55 years+ - NCT07447050RecruitingPhase 2
Riluzole to Prevent Chemo-Related Cognitive Problems
This pilot study tests whether the drug riluzole can help prevent the thinking and memory problems (often called 'chemobrain') that some people experience during chemotherapy. If you are about to start a chemo regimen containing an anthracycline or platinum drug, you may be able to join.
Orange, CaliforniaAges 18 years+ - NCT07430800Recruiting
AI-Powered CBT for Anxiety in University Students
This study tests whether personalized computer models can improve cognitive behavioral therapy (a talk therapy that helps change thinking patterns) for anxiety. It's for university students who have mild to moderate anxiety and are comfortable with being recorded during sessions.
Los Angeles, CaliforniaAges 18 years+ - NCT07397858Recruiting
Brain stimulation for depression in young people
This study tests if a type of brain stimulation called Transcranial Magnetic Stimulation (TMS) can help treat depression in people aged 15 to 25. It involves a quick, non-invasive treatment that uses magnetic pulses to the head, and researchers want to see how it affects thinking and mood.
Sacramento, CaliforniaAges 15–25 - NCT07396220Enrolling by invitation
Psychotherapy with esketamine nasal spray for suicidal thoughts
This study tests combining a specific type of therapy (BCBT-SP) with esketamine nasal spray to help people with treatment-resistant depression who are having ongoing suicidal thoughts. The goal is to see if this combination can reduce suicidal ideation more effectively than either treatment alone.
San Diego, CaliforniaAges 18–70 - NCT07388641Recruiting
Helping homeless-experienced veterans find work or training
This study helps veterans who have experienced homelessness and are now in stable housing reach their work, school, or training goals. It tests ways to improve community integration.
West Los Angeles, CaliforniaAges 18–65 - NCT05980117RecruitingPhase 4
Remimazolam sedation for cataract surgery
This study tests a sedative, remimazolam, for older adults having their first cataract surgery. It aims to see if it helps keep patients comfortable and calm without needing general anesthesia.
Los Angeles, CaliforniaAges 65 years+ - NCT07281352RecruitingPhase 1/Phase 2
Psilocybin therapy for depression
This study tests if psilocybin (a psychedelic) combined with cognitive behavioral therapy (CBT) can help people with major depression. You would receive the psilocybin in a supervised setting and have talk therapy before and after.
Los Angeles, CaliforniaAges 21–60 - NCT07226908Enrolling by invitation
Brain electrode study for epilepsy and memory
This study places electrodes in the brain to learn how seizures spread and how memory works. It may help people with temporal lobe epilepsy understand their condition better and improve future treatments.
Stanford, CaliforniaAges 18–65 - NCT07218757Recruiting
Trial of emotional awareness therapy for veterans with chronic pain
This study tests if a type of therapy that helps you understand and express emotions related to pain (called Emotional Awareness and Expression Therapy) can reduce chronic pain in veterans. It is designed for veterans who have had muscle or joint pain for at least 3 months and rate their pain as moderate or greater.
Los Angeles, CaliforniaAges 18 years+ - NCT07207122Recruiting
Focused ultrasound for Parkinson's cognitive symptoms
This trial tests whether a non-invasive ultrasound treatment, called transcranial focused ultrasound stimulation (tFUS), can improve movement and thinking in people with Parkinson's disease. It may be an option for those whose symptoms are not well controlled by medication alone.
Santa Monica, CaliforniaAges 22–80 - NCT06367764Recruiting
PTSD treatment study for sexual and gender minorities
This study compares different treatments for PTSD specifically designed for people who are sexual or gender minorities. It aims to find which approach works best for this community, and you can join sessions in person or by video.
San Francisco, CaliforniaAges 18 years+ - NCT07190365Recruiting
Goal-oriented telehealth rehab for veterans with brain injury
This trial tests a telehealth program to help veterans with long-term thinking and planning problems after a mild to moderate brain injury. It aims to improve your daily life and community involvement.
Palo Alto, CaliforniaAges 18–65 - NCT07141394Enrolling by invitation
Supporting recovery for homeless veterans in VA housing
This trial helps homeless veterans in VA supportive housing get coordinated access to addiction recovery services. It aims to improve equity and outcomes for those in recovery.
West Los Angeles, CaliforniaAges Any age - NCT07055633Recruiting
Improving cognitive rehab for veterans with concussion and PTSD
This trial tests a program to help veterans with memory, attention, or thinking problems after a mild concussion (mTBI) and with PTSD. It also looks at depression and sleep issues. The goal is to improve thinking and daily life.
San Diego, CaliforniaAges 18 years+ - NCT07036705Recruiting
Sauna blanket and app for better sleep in insomnia
This study tests whether using a heated sauna blanket before bed, along with a mind-body app, can help adults with insomnia fall asleep faster and sleep better. You would use the blanket at home for a few weeks and answer questions about your sleep.
San Francisco, CaliforniaAges 18 years+ - NCT06976203RecruitingPhase 3
Testing karxt for thinking problems in alzheimer's
This trial tests if a combination medicine, KarXT plus KarX-EC, can help with thinking and memory problems in people with mild to moderate Alzheimer's disease. It aims to see if the treatment is safe and effective.
Fullerton, CaliforniaAges 60–85 - NCT06976216RecruitingPhase 3
Study of KarXT plus KarX-EC for Alzheimer's cognitive symptoms
This trial tests a new combination treatment (KarXT plus KarX-EC) to see if it can help with thinking and memory problems caused by Alzheimer's disease. It is for people with mild to moderate Alzheimer's who have a caregiver available.
Long Beach, CaliforniaAges 60–85 - NCT06972004Enrolling by invitation
Preventing loss of independence through exercise for veterans
This study tests a gentle exercise program for veterans living in VA community living centers. The program is designed to help residents with memory problems stay independent, move better, and feel better. Staff at the center will be trained to lead the classes.
San Francisco, CaliforniaAges 18 years+ - NCT06915324Recruiting
Electric brain stimulation for Lyme disease cognitive issues
This study tests if a gentle electrical current applied to the scalp can improve thinking problems (like slow processing speed) that continue after Lyme disease treatment. It could help you if you have mental fog or memory trouble that hasn't gone away with antibiotics.
San Francisco, CaliforniaAges 18–70 - NCT06916221Recruiting
Digital brain training in aging
This study tests whether a digital intervention can help older adults (60+) maintain or improve cognitive function. It is designed for healthy adults or those with mild cognitive impairment (MCI), and people who do not regularly play a musical instrument or have extensive music training.
San Francisco, CaliforniaAges 60–85 - NCT06918704Recruiting
Digital brain health program for older adults
This study tests a digital program designed to help support thinking and memory in older adults. It may be a good fit if you are 60+ and generally healthy, even if you have some mild memory concerns.
San Francisco, CaliforniaAges 60–85 - NCT06889961Recruiting
Daily mixed spice consumption for memory health
This trial tests whether eating a mix of spices every day can help improve memory in older adults with mild memory changes. If you are between 50 and 80 and have no major health conditions, you may be able to join.
Los Angeles, CaliforniaAges 50–80
Where these studies are running in California
Institutions with a site for the recruiting cognition studies listed above.
- University of California, San Francisco · 2 studies
- VA Greater Los Angeles Healthcare System, West Los Angeles, CA · 2 studies
- Anderson Clinical Research
- Chao Family Comprehensive Cancer Center, University of California Irvine
- Foster Carr MD
- Healthy Brain Clinic
- Inglewood Clinical
- Irvine Clinical Research
What taking part in a cognition study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Cognition trials in other states
Common questions
- Are there cognition clinical trials in California?
- Yes. We're currently tracking 124 recruiting cognition studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cognition study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cognition trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cognition studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.