Clinical trials · California
Cognitive Decline clinical trials in California
We’re tracking 13 recruiting cognitive decline studies with a site in California — including Phase 1/Phase 2, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT06507254Recruiting
Polyphenols and brain health in aging
This study tests whether eating more polyphenols (natural compounds in plants) can protect brain health in people at higher risk for Alzheimer's disease, especially if they currently eat a typical Western diet. Participants will be followed over time to see if changes in diet affect thinking and memory.
Los Angeles, CaliforniaAges 50 years+ - NCT04800588Recruiting
Computer tests to study early Alzheimer’s changes
This study uses computer and touch-screen tasks to measure thinking changes in people who may be in the early, symptom-free stage of Alzheimer’s disease. It aims to understand how these brain-related changes show up on testing, which could help future detection or tracking.
Berkeley, CaliforniaAges 18–89 - NCT07547319Recruiting
Accelerated rTMS to improve cognitive function
This study tests whether repeated magnetic pulses to the brain (called rTMS) can help improve thinking and memory in older adults with mild to moderate cognitive decline. The treatment is non-invasive and may help slow cognitive changes.
San Francisco, CaliforniaAges 50–90 - NCT04171323Recruiting
Active mind training to improve thinking and delay dementia
This study tests an “active mind” computer-based program to help improve thinking skills and possibly slow the process toward dementia. You may be randomly assigned to different program options to see which approach works best for your goals.
San Francisco, CaliforniaAges 55–89 - NCT03860857RecruitingPhase 3
Study biomarkers in memory aging and brain health
This Phase 3 study looks for blood/brain “biomarkers” linked to aging, memory changes, and early brain degeneration. It may help researchers better identify who is at risk and how biology relates to thinking and memory, using brain scans and thinking tests.
Irvine, CaliforniaAges 60 years+ - NCT07220694Recruiting
Sabroxy supplement for memory and insulin resistance
This study tests whether a supplement called Sabroxy can improve insulin resistance and memory in adults with mild cognitive impairment and insulin resistance. It may help if you have early memory problems and your blood sugar is slightly higher than normal.
San Francisco, CaliforniaAges 40–80 - NCT07130669RecruitingPhase 1/Phase 2
Memory and thinking study for older adults
This trial tests a program to help maintain or improve memory and thinking skills in older adults. You may join if you are 60-89, speak English, and live at home or in an assisted-living facility.
Palo Alto, CaliforniaAges 60–89 - NCT06870136Recruiting
Lion's Mane supplement for memory and focus
This study tests a Lion's Mane supplement to see if it helps with memory, focus, and overall thinking. If you are between 40 and 75 and have mild concerns about your thinking, you may be able to take part.
Los Angeles, CaliforniaAges 40–75 - NCT07589595RecruitingPhase 2
Donanemab for Early Cognitive Decline with Lewy Bodies
This study tests donanemab, an investigational drug designed to target amyloid proteins in the brain that may contribute to cognitive decline in people with early dementia with Lewy bodies. The trial aims to see if this treatment can slow cognitive decline and help preserve thinking and memory.
Carlsbad, CaliforniaAges 55–85 - NCT06397469Recruiting
Digital program for attention and wellbeing in older adults
This study tests a digital program designed to help improve attention and overall wellbeing in older adults. You can take part from home using your own smartphone or tablet.
San Francisco, CaliforniaAges 60–99 - NCT06410157Recruiting
Mindfulness for heart-brain health in adults 50-70
This study tests whether a daily mindfulness practice can help older adults improve how their heart and brain work together. You will do breathing exercises at home and come to USC twice for check-ups, including blood and urine tests and an MRI.
Los Angeles, CaliforniaAges 50–70 - NCT02434393Recruiting
Studying brain changes in late-life depression and memory decline
This study looks at how thinking and memory change in people with depression later in life, using brain imaging and related assessments. Your past participation and whether your treatments are stable enough around the time of the brain scan may determine whether you can join.
San Francisco, CaliforniaAges 65 years+ - NCT05625425Recruiting
Study testing a memory and wayfinding training program
This study tests a wayfinding (getting around) training program and how it may affect long-term memory. You may need brain scans (fMRI), virtual reality tasks, and regular short walks to participate.
San Francisco, CaliforniaAges 60–85
Cognitive Decline trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting cognitive decline studies listed above.
- University of California, San Francisco · 4 studies
- Altman Clinical and Translational Research Institute
- Neurobehavioral Systems, Inc.
- People Science
- Profound Research LLC
- Research Site
- San Francisco Neurology and Sleep Center
- San Francisco Research Institute
What taking part in a cognitive decline study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Cognitive Decline trials in other states
Common questions
- Are there cognitive decline clinical trials in California?
- Yes. We're currently tracking 13 recruiting cognitive decline studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cognitive decline study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cognitive decline trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cognitive decline studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.