Clinical trials
Cognitive Decline clinical trials
Below are recruiting cognitive decline clinical trials, each written for real people, not researchers. We’re tracking 181 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06429215Recruiting
Virtual reality and telemedicine to lower dementia risk
This trial tests whether a program using virtual reality and telemedicine can help lower the risk of memory decline and dementia in people who feel their thinking is slipping but don't have a diagnosed memory problem.
Rome, LazioAges 55–80 - NCT07402161Recruiting
Finding Alzheimer's earliest signature in memory concerns
This study looks for early signs of Alzheimer's in people who feel their memory is slipping but still function normally. You'll help researchers find a pattern—a 'signature'—in the brain that may signal the earliest stages of the disease.
San Donato Milanese, MilanAges 18 years+ - NCT06816797Recruiting
Testing a program for older adults worried about memory
This trial tests a program called Cog-Fun Aging to help older adults who notice memory changes and feel concerned. The study looks at whether the program can improve daily function and well-being.
JerusalemAges 60 years+ - NCT03360838Recruiting
Prediction test for confusion after heart surgery in older adults
This study uses a short, self-answered thinking test before elective heart surgery to help predict who may develop confusion afterward. The goal is to improve early identification and care planning for patients at higher risk.
BaselAges 60 years+ - NCT03451383Recruiting
Study brain changes in older breast cancer patients
This study follows older women with newly diagnosed breast cancer to see who might develop thinking or memory problems over time. It may help researchers understand early brain risk and how treatment and other factors relate to cognitive decline.
Washington D.C., District of ColumbiaAges 60–105 - NCT05014893Recruiting
Brain testing and rehab study for thinking changes
This study looks at how brain activity relates to thinking problems and whether a cognitive (thinking) assessment and rehab approach can help adults with memory or thinking changes. You may be asked to take thinking tests and complete study activities during rehab.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05815329Recruiting
Study of changes in people who feel their thinking is getting worse
This study looks at how people’s thoughts and memory feel to them when they report subjective cognitive decline, using questionnaires and assessments. It may help researchers understand this early “thinking feels worse” stage and what it looks like in real life.
Montescano, PaviaAges 55 years+ - NCT06507254Recruiting
Polyphenols and brain health in aging
This study tests whether eating more polyphenols (natural compounds in plants) can protect brain health in people at higher risk for Alzheimer's disease, especially if they currently eat a typical Western diet. Participants will be followed over time to see if changes in diet affect thinking and memory.
Los Angeles, CaliforniaAges 50 years+ - NCT06669546Recruiting
Quiet sounds during deep sleep for memory in older adults
This study tests whether playing a soft, silent sound (or no sound) during deep sleep can improve memory, brain activity, and blood markers. It is for older adults (60-85) who have mild memory issues but are otherwise healthy.
BernAges 60–85 - NCT06701630Recruiting
Italian study of daily thinking and memory scales
This study is testing new questionnaires to better understand everyday thinking and memory problems in older adults. It aims to improve how doctors identify and track conditions like mild cognitive impairment and early dementia.
Milan, MichiganAges 60 years+ - NCT06711952Recruiting
German study of a new memory questionnaire
This study tests a new questionnaire designed to help doctors better understand early memory or thinking problems. It takes place at a memory clinic in Munich and is for people who are already coming in for dementia testing.
München, BavariaAges 50 years+ - NCT06727773RecruitingPhase 2
Memantine and exercise to protect thinking during chemo for breast cancer
This study tests whether a medicine called memantine combined with a structured exercise program can help protect your thinking and memory during chemotherapy for breast cancer. It may also help understand how these treatments work in the body.
Chapel Hill, North CarolinaAges 18 years+ - NCT07207993Recruiting
AI fitness wearables for older adults with mild memory concerns
This study tests if using an AI-powered fitness wearable and app can help older adults living alone who have mild memory problems stay active. It aims to see if the technology improves health and well-being.
Knoxville, TennesseeAges 65 years+ - NCT07250789Recruiting
Brain Care Study: Screen and help for thinking decline in type 2 diabetes
This study screens older adults with type 2 diabetes for early signs of memory or thinking problems, and offers a program to help keep the brain healthy. It aims to find out if a combination of lifestyle changes, mental exercises, and medical support can slow cognitive decline.
CopenhagenAges 65 years+ - NCT07289061Recruiting
Positive psychology for early memory changes
This trial tests whether positive psychology exercises can help improve memory and brain function in people with very early memory changes. It may be a good fit if you have noticed new memory concerns or a mild cognitive impairment.
ThessalonikiAges Any age - NCT06758154Recruiting
Electro-acupuncture for subjective cognitive decline
This study tests whether electro-acupuncture can improve thinking and memory in people with subjective cognitive decline (when you notice memory issues but standard tests are still normal). It involves receiving acupuncture and brain scans over a period of time.
Nanjing, JiangsuAges 55–79 - NCT07395609Recruiting
Brain stimulation to boost memory, movement, and mood in older adults
This study tests whether high-frequency electrical stimulation of the brain can help improve thinking, movement, and mood in older adults who may or may not have early signs of memory decline. Participants will get sessions of stimulation and complete thinking and walking tasks.
Gainesville, FloridaAges 65–89 - NCT06622889Enrolling by invitation
Can changing how you see aging help memory?
This study tests whether changing how older adults think about aging can help with memory concerns. If you are 60+ and feel your memory or thinking is declining (but tests are normal), you may be able to join.
Beijing, Beijing MunicipalityAges 60 years+ - NCT07731334Recruiting
Memory problems in non-neurology rehab patients
This study looks at how common mild cognitive impairment and dementia are in people staying in rehabilitation units for heart, lung, or orthopedic problems. It aims to understand memory and thinking issues that may be overlooked in these settings.
Florence, FIAges 45 years+ - NCT03851523Recruiting
Tracking memory changes in people with early Alzheimer’s symptoms
This study follows people over time to better understand how memory and thinking complaints progress in early Alzheimer’s disease (from “subjective cognitive decline” to mild cognitive problems). It may help researchers understand who is likely to decline and how symptoms change, which could support future treatments.
Barcelona, CataloniaAges 45 years+ - NCT06335836Recruiting
Social connections and brain health in memory decline
This study looks at how being socially isolated or socially active affects memory and brain health in people who feel their thinking is getting worse. You may join if you notice a slow decline in memory or thinking, but otherwise have normal test results.
Nanjing, China, JiangsuAges 45–85 - NCT07081282Recruiting
Study on frailty and thinking decline in older adults
This study looks at how to better understand and predict frailty and memory changes in older adults with at least one chronic condition. It aims to use a simple screening to personalize care and help you stay independent longer.
SingaporeAges 60–85 - NCT07127965Recruiting
Exercise program to prevent memory loss in Black adults
This study looks at whether a structured exercise program can help slow down memory and thinking changes in Black adults ages 45–65. You would be asked to take part in a supervised exercise routine over several months, and your health and cognition will be tracked.
Aurora, ColoradoAges 45–65 - NCT04800588Recruiting
Computer tests to study early Alzheimer’s changes
This study uses computer and touch-screen tasks to measure thinking changes in people who may be in the early, symptom-free stage of Alzheimer’s disease. It aims to understand how these brain-related changes show up on testing, which could help future detection or tracking.
Berkeley, CaliforniaAges 18–89
Hear when a new Cognitive Decline trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Cognitive Decline trials by city
Studies with a site in or near these metro areas.
Cognitive Decline trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for cognitive decline?
- Yes. Clin2 currently lists 181 recruiting cognitive decline studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognitive decline trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognitive decline trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.