Clinical trials
Crohn's Disease, Active clinical trials
Below are recruiting crohn's disease, active clinical trials, each written for real people, not researchers. We’re tracking 194 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06456593RecruitingPhase 2
Obefazimod for moderate to severe Crohn's disease
This trial tests an experimental oral medication called obefazimod for people with moderate to severe Crohn's disease. It aims to see if the drug can reduce inflammation and improve symptoms when other treatments have not worked well.
Fairhope, AlabamaAges 18–75 - NCT06538649RecruitingEarly Phase 1
Testing statins for Crohn's disease before and after surgery
This study tests whether taking a statin (a cholesterol-lowering medicine) before and after surgery for Crohn's disease can help improve outcomes. It's for people with a specific type of Crohn's that causes narrowing in the small intestine and who are already scheduled for surgery.
Stanford, CaliforniaAges 18–80 - NCT06226883RecruitingPhase 2
Testing MORF-057 for moderate to severe Crohn's disease
This study tests an oral medicine called MORF-057 for people with moderate to severe Crohn's disease. It aims to see if the drug can reduce inflammation and improve symptoms for those who haven't had success with other treatments.
Lancaster, CaliforniaAges 18–85 - NCT06233461RecruitingPhase 2
A study of TAK-279 for Crohn's disease
This study tests an oral medication called TAK-279 to see if it can safely reduce inflammation in the bowel for people with moderate to severe Crohn's disease who haven't had success with other treatments.
Murrieta, CaliforniaAges 18–75 - NCT06742385Recruiting
Smartphone app to monitor active inflammatory bowel disease
This study tests a smartphone app (SEMEIA) to help monitor people with active Crohn's disease or ulcerative colitis. It may help you track your symptoms and stay in touch with your doctor without needing as many office visits.
Neuilly-sur-Seine, FranceAges 18–80 - NCT06890637Recruiting
Fecal transplant and diet change for Crohn's disease
This trial tests whether a fecal transplant (putting healthy bacteria into your gut) combined with dietary changes can help control active Crohn's disease. It is for people who need stronger treatments or have stopped responding to their current therapy.
Kochi, KeralaAges 18–75 - NCT06890650Recruiting
Fecal transplant and diet for new Crohn's disease
This study tests whether a combination of fecal transplant (transferring healthy bacteria from a donor) and dietary changes can help control disease activity in people newly diagnosed with Crohn's. It is for those with mild to moderate symptoms who have not yet taken any Crohn's medications.
Kochi, KeralaAges 18–75 - NCT06925061RecruitingPhase 2
Testing EXL01 to prevent Crohn's disease return after surgery
This study tests a new oral treatment called EXL01 to see if it can prevent Crohn's disease from coming back after surgery to remove part of the small and large intestine. It may be an option if you are not planning to use strong immune-suppressing drugs (except anti-TNF) in the next 6 months.
Clermont-FerrandAges 18 years+ - NCT06937099RecruitingPhase 3
Testing two drugs for Crohn's with weight issues
This trial tests two study drugs, mirikizumab and tirzepatide, in people with moderate to severe Crohn's disease who also have overweight or obesity. The goal is to see if these treatments can help control Crohn's symptoms and inflammation.
Dothan, AlabamaAges 18–70 - NCT07078994RecruitingPhase 2
Study of a new drug for moderate to severe Crohn's disease
This trial tests a new medicine called BCD-261 for people with moderate to severe Crohn's disease that has not responded well to other treatments. It aims to see if the drug can reduce symptoms and inflammation.
Barnaul, Altayskiy KrayAges 18–75 - NCT07184944RecruitingPhase 3
Study of Duvakitug for moderate to severe Crohn's disease
This study tests a new drug called duvakitug to see if it can help maintain improvement in people with moderate to severe Crohn's disease. It's for patients who have already responded to treatment in a previous study.
Colorado Springs, ColoradoAges 16–80 - NCT07231601Recruiting
Laparoscopic surgery for Crohn's disease of the small intestine
This trial tests a specific laparoscopic (keyhole) surgery technique for Crohn's disease affecting the last part of the small intestine. It aims to see if removing more of the fatty tissue around the bowel leads to better outcomes. If you have Crohn's disease needing surgery in this area, you may be eligible.
Piraeus, AtticaAges 16 years+ - NCT07545317Recruiting
IL-23 Inhibitors for Active Crohn's Disease
This study follows patients with moderate-to-severe Crohn's disease who are starting a newer type of biologic medication called IL-23 inhibitors (guselkumab or risankizumab). Researchers want to understand how well these drugs work in real-world clinical practice and compare their effectiveness to other treatments.
Guangzhou, GuangdongAges 18–75 - NCT07314606Recruiting
Diet plus infliximab for kids with Crohn’s
This study tests if a special diet (called CDED) combined with infliximab (a biologic drug) is more effective than infliximab alone for children with newly diagnosed or relapsed moderate-to-severe Crohn’s disease. It aims to improve gut healing and reduce inflammation.
Vancouver, British ColumbiaAges 9–17 - NCT07184931RecruitingPhase 3
Testing duvakitug for active Crohn's disease
This study tests a new drug called duvakitug for people with moderately to severely active Crohn's disease who haven't responded well to other treatments. It aims to see if the drug can reduce symptoms and improve quality of life.
Peoria, ArizonaAges 16–80 - NCT02421705Recruiting
Brain-gut sensitivity study in IBS and inflammatory bowel disease
This study checks how sensitive your gut is to normal stimuli in people with IBS, ulcerative colitis, Crohn’s disease, and in healthy volunteers. Results may help researchers understand why some people feel more abdominal discomfort and how that connects to inflammatory bowel conditions.
Leuven, Vlaams-BrabantAges 18–65 - NCT07504510Recruiting
Exclusive liquid nutrition for active Crohn's disease
This trial tests whether a special liquid-only diet (exclusive enteral nutrition) can help people with active Crohn's disease, including those with complications like fistulas or narrowing of the intestine. It aims to improve nutrition and reduce disease activity without medication.
Guangzhou, GuangdongAges 18 years+ - NCT07649408Recruiting
How New Crohn's Treatments Affect Sleep Quality
This study looks at whether new biologic or targeted medications for Crohn's disease improve sleep quality. You would wear a watch while sleeping and answer questions about your sleep to help researchers understand if these advanced treatments help you sleep better.
Tel AvivAges 18 years+ - NCT07652632Recruiting
Regenerative endoscopy for hard-to-treat Crohn's fistulas
This trial tests a new, less invasive procedure called regenerative endoscopy to repair complex fistulas in people with Crohn's disease. It's for those who haven't gotten better with standard treatments like biologics or surgery.
Hyderabad, TelanganaAges 18–65 - NCT06722456Enrolling by invitation
Better ways to detect active IBD
This study tests non-invasive tools to find active inflammation in people with Crohn's disease or ulcerative colitis. You may need to give extra stool samples before your colonoscopy and calprotectin test.
Sherbrooke, QuebecAges 18 years+ - NCT07077746RecruitingPhase 2
Stem cells for Crohn's disease
This trial tests whether a type of stem cell called HB-adMSCs can help treat Crohn's disease. It is for adults with mild to moderate Crohn's who have certain signs of inflammation in their blood and recent imaging of their condition.
Sugar Land, TexasAges 18–65 - NCT04263831RecruitingPhase 1/Phase 2
Low-dose IL-2 to treat Crohn’s disease flare-ups
This trial tests a low dose of IL-2 to reduce inflammation and help control Crohn’s disease symptoms. It’s for people whose Crohn’s disease hasn’t responded to at least one standard treatment or who need steroids to stay under control.
Boston, MassachusettsAges 12–80 - NCT07471438Recruiting
MRI comparison for Crohn's disease activity in the ileum
This trial compares two types of MRI scans to see how well they detect inflammation in the small intestine of people with Crohn's disease. It aims to find the best way to assess disease activity without invasive procedures.
AmiensAges Any age - NCT04224558RecruitingPhase 1/Phase 2
Stem cell transplant for hard-to-control Crohn’s disease
This early-phase study tests whether a stem cell transplant can improve Crohn’s disease in teens and young adults whose disease is active and not responding to standard medicines. It may help some people who are not doing well despite several prior treatments, but it also involves intensive study procedures and safety checks.
Los Angeles, CaliforniaAges 13–28
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Common questions
- Are there clinical trials for crohn's disease, active?
- Yes. Clin2 currently lists 194 recruiting crohn's disease, active studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a crohn's disease, active trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a crohn's disease, active trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.