Clinical trials
Crohn's Disease, Active clinical trials
Below are recruiting crohn's disease, active clinical trials, each written for real people, not researchers. We’re tracking 195 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04637438Recruiting
Fecal transplant for Crohn’s around the small and large bowel
This trial studies fecal microbiota transplantation (a transplant of beneficial gut bacteria from a donor) to help people with Crohn’s disease that is causing narrowing (strictures) and/or abnormal tunnels (fistulas) and who need bowel surgery. You may qualify if you’re an adult, planning ileal/ileocecal surgery, and can complete the colonoscopy while not on certain gut-altering medicines.
TampereAges 18–120 - NCT04946448Recruiting
Test a Crohn’s diet and biologic medicine combination
This study tests whether combining a specific diet with biologic medicines can reduce active inflammation and symptoms of Crohn’s disease. It may help people who still have active disease in the bowel despite prior care.
LeuvenAges 18–80 - NCT05043870RecruitingPhase 4
Testing medicines that calm the immune system in kids with Crohn’s
This trial studies a combination of immune-suppressing treatments for children with Crohn’s disease that is not well controlled. It may help reduce inflammation and improve symptoms if you meet the study’s disease-activity and safety requirements.
Shanghai, Shanghai MunicipalityAges 6–18 - NCT05387031Recruiting
Ustekinumab for painful Crohn’s bowel narrowing
This trial tests ustekinumab, a medicine that calms immune inflammation, to see if it can improve symptoms in people with Crohn’s disease that causes bowel narrowing. It may help if your Crohn’s symptoms come from strictures (narrowed areas) seen on scans or endoscopy.
Beijing, Beijing MunicipalityAges 18–65 - NCT05552287RecruitingPhase 4
Infliximab drug levels in children with Crohn’s disease
This study measures how infliximab (a medicine that calms immune inflammation) moves through the body in children with Crohn’s disease. It mainly helps doctors understand dosing and drug levels, especially when treatment is newly starting.
RotterdamAges 1–15 - NCT05578235Recruiting
Surgery for Crohn’s: hand-sewn vs stapled bowel connection
This trial compares two ways of reconnecting the bowel after removing diseased intestine in people with Crohn’s disease. The goal is to see which method works better for healing and short- and longer-term outcomes.
Almere Stad, FlevolandAges 16 years+ - NCT05321745Recruiting
Fecal transplant for children with Crohn’s disease
This trial tests whether transferring stool microbes (called fecal microbiota transplantation, or FMT) can improve Crohn’s disease in children who have not gotten better with usual treatments. If you qualify, the study will check symptoms and colon imaging/score changes over the study follow-up.
Wuhan, HubeiAges 2–16 - NCT06520397RecruitingPhase 4
Combination therapy vs. higher dose ustekinumab for Crohn's
This trial tests whether a combination of two drugs (upadacitinib and ustekinumab) works better than a higher dose of ustekinumab alone for people with active Crohn's disease that hasn't responded well to previous treatments.
Guangzhou, GuangdongAges 18–70 - NCT06631586RecruitingPhase 2
Microbiota transplant for Crohn's disease
This study tests if a standardized fecal transplant is safe and helpful for adults with moderately to severely active Crohn's disease who are already on maintenance therapy. The goal is to see if this treatment can reduce inflammation in the digestive tract.
Minneapolis, MinnesotaAges 18–89 - NCT06721962RecruitingPhase 1/Phase 2
Testing an experimental treatment for moderate to severe Crohn's disease
This trial is testing a new investigational treatment called TRX103 for adults with moderate to severe Crohn's disease that has not responded to at least two other advanced therapies. The study aims to see if this treatment can reduce inflammation and improve symptoms.
Scottsdale, ArizonaAges 18–65 - NCT06976853RecruitingPhase 2
Testing a new drug for Crohn’s disease beyond inflammation
This study tests a medicine called tirzepatide to see if it can help people with active Crohn’s disease who have not responded to multiple prior treatments. It focuses on how the drug might work beyond just reducing inflammation.
Beverly Hills, CaliforniaAges 18–80 - NCT07363044Recruiting
Biologic selection guided by epigenetic markers in Crohn's disease
This trial compares two different ways to choose your Crohn's treatment: one based on a special test of your cells (epigenetic markers) and the other based on standard care. It aims to see which approach works better for people with moderate to severe Crohn's disease.
AntwerpAges 18 years+ - NCT07364734Recruiting
Study of hard-to-treat Crohn's disease
This study looks at people with Crohn's disease that is hard to treat. It aims to understand the disease better and see how well current treatments work.
Guangzhou, GuangdongAges 18–65 - NCT03219359RecruitingPhase 2
Stem cell transplant using your own cells for Crohn’s flare
This Phase 2 study tests whether a transplant using your own stem cells can calm active Crohn’s disease that hasn’t improved with standard medicines. It may help some people with ongoing inflammation and symptoms after multiple Crohn’s treatments.
New York, New YorkAges 18 years+ - NCT07629245RecruitingPhase 1/Phase 2
Cell therapy for Crohn's disease fistulas after prior treatment
This trial tests whether injecting your own fat-derived cells combined with a skin graft can heal anal fistulas (abnormal passages near the anus) that didn't respond to or came back after a previous cell therapy study. You must have already participated in the ADICROHN-2 study.
MarseilleAges 18 years+ - NCT06165289Enrolling by invitation
Balloon dilation with PRP for Crohn's colon narrowing
This trial tests whether adding a platelet-rich plasma (PRP) injection to the standard balloon dilation procedure can help treat a narrowed section of the colon caused by Crohn's disease. It may offer a way to avoid or delay surgery for some patients.
Guangzhou, GuangdongAges 18 years+ - NCT06523647Recruiting
Effectiveness of Ustekinumab for Crohn's Disease
This study looks at how well Ustekinumab (Stelara) works for Crohn's disease in people who started the medication in 2024. Researchers want to understand its real-world benefits and safety.
AktobeAges 18 years+ - NCT07444060Recruiting
Guselkumab vs Ustekinumab for stricturing Crohn's disease
This study compares two medicines, Guselkumab and Ustekinumab, for people with Crohn's disease that causes narrowing (strictures) in the bowel. It aims to find which works better to improve symptoms and avoid the need for more procedures.
Hangzhou, ZhejiangAges 18–80 - NCT06045754RecruitingPhase 4
Study of vedolizumab with other drugs for Crohn's disease
This trial tests whether combining vedolizumab with adalimumab or ustekinumab helps people with moderate to severe Crohn's disease who haven't responded to other treatments. It aims to find better ways to manage symptoms and improve quality of life.
Dothan, AlabamaAges 18–70 - NCT05509777RecruitingPhase 3
Mirikizumab for children with active Crohn’s disease
This study tests mirikizumab to reduce inflammation and symptoms in children with Crohn’s disease that is currently active. It may help if your Crohn’s has not improved enough (or stopped working) with at least one other Crohn’s medicine.
Los Angeles, CaliforniaAges 2–17 - NCT05683730Recruiting
Intermittent calorie restriction for mild to moderate Crohn’s
This trial studies whether planned periods of eating fewer calories can help people with mild to moderate Crohn’s disease. It requires stable Crohn’s treatment and monitoring for weight and health changes during the study.
Vandœuvre-lès-Nancy, CHRU de NancyAges 18–65 - NCT05837897RecruitingPhase 3
Vedolizumab for adults with moderate-to-severe Crohn’s
This Phase 3 study tests whether vedolizumab can better control moderate-to-severe Crohn’s disease in adults whose symptoms haven’t improved enough with other treatments. You’d need to meet specific symptom scores, recent colonoscopy findings, and safety checks (including infections and vaccination status).
Hefei, AnhuiAges 18–80 - NCT05849012Recruiting
Low-sulfur diet study for Crohn’s symptoms when disease is quiet
This pilot study tests whether a low-sulfur diet can improve ongoing belly pain and/or diarrhea symptoms in people with Crohn’s disease that looks “quiet” on tests. If you still feel symptoms even though inflammation is not active, this could help by targeting diet-related triggers.
Ann Arbor, MichiganAges 18 years+ - NCT05906576RecruitingPhase 4
Infliximab monitoring study for children with Crohn’s disease
This study keeps track of how infliximab works and how safe it is in Chinese children with moderate-to-severe active Crohn’s disease. You may be eligible if this is the first time your child is starting infliximab and you agree to provide study information.
BeijingAges 6–17
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Common questions
- Are there clinical trials for crohn's disease, active?
- Yes. Clin2 currently lists 195 recruiting crohn's disease, active studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a crohn's disease, active trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a crohn's disease, active trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.