Clinical trials
Crohn's Disease, Active clinical trials
Below are recruiting crohn's disease, active clinical trials, each written for real people, not researchers. We’re tracking 198 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05578235Recruiting
Surgery for Crohn’s: hand-sewn vs stapled bowel connection
This trial compares two ways of reconnecting the bowel after removing diseased intestine in people with Crohn’s disease. The goal is to see which method works better for healing and short- and longer-term outcomes.
Almere Stad, FlevolandAges 16 years+ - NCT07833332Recruiting
Comparing two procedures for blocked small bowel in Crohn's disease
This study compares two procedures—endoscopic stricturotomy and balloon dilation—to treat a narrowed section (stricture) in the small bowel caused by Crohn's disease. If you have a partial blockage, this trial aims to see which procedure is better at safely opening the bowel.
Guangzhou, GuangdongAges 18–70 - NCT07625293RecruitingPhase 2
DB-3Q for treatment-resistant Crohn's disease
This trial tests a new medicine called DB-3Q for people with Crohn's disease that hasn't responded to standard biologic treatments or causes side effects. The study aims to see if DB-3Q can reduce inflammation and symptoms in people whose disease is hard to control.
St Louis, MissouriAges 18–75 - NCT07629245RecruitingPhase 1/Phase 2
Cell therapy for Crohn's disease fistulas after prior treatment
This trial tests whether injecting your own fat-derived cells combined with a skin graft can heal anal fistulas (abnormal passages near the anus) that didn't respond to or came back after a previous cell therapy study. You must have already participated in the ADICROHN-2 study.
MarseilleAges 18 years+ - NCT07471438Recruiting
MRI comparison for Crohn's disease activity in the ileum
This trial compares two types of MRI scans to see how well they detect inflammation in the small intestine of people with Crohn's disease. It aims to find the best way to assess disease activity without invasive procedures.
AmiensAges Any age - NCT07364734Recruiting
Study of hard-to-treat Crohn's disease
This study looks at people with Crohn's disease that is hard to treat. It aims to understand the disease better and see how well current treatments work.
Guangzhou, GuangdongAges 18–65 - NCT07363044Recruiting
Biologic selection guided by epigenetic markers in Crohn's disease
This trial compares two different ways to choose your Crohn's treatment: one based on a special test of your cells (epigenetic markers) and the other based on standard care. It aims to see which approach works better for people with moderate to severe Crohn's disease.
AntwerpAges 18 years+ - NCT07263880RecruitingPhase 1/Phase 2
Clostridium Butyricum for stricturing Crohn's disease
This trial tests a bacteria called Clostridium butyricum to see if it can help people with a type of Crohn's disease that causes narrowing in the right colon or ileocecal area. It may offer a new option for those not on strong immune-suppressing medications.
RomaAges 18–85 - NCT07077746RecruitingPhase 2
Stem cells for Crohn's disease
This trial tests whether a type of stem cell called HB-adMSCs can help treat Crohn's disease. It is for adults with mild to moderate Crohn's who have certain signs of inflammation in their blood and recent imaging of their condition.
Sugar Land, TexasAges 18–65 - NCT06976853RecruitingPhase 2
Testing a new drug for Crohn’s disease beyond inflammation
This study tests a medicine called tirzepatide to see if it can help people with active Crohn’s disease who have not responded to multiple prior treatments. It focuses on how the drug might work beyond just reducing inflammation.
Beverly Hills, CaliforniaAges 18–80 - NCT06721962RecruitingPhase 1/Phase 2
Testing an experimental treatment for moderate to severe Crohn's disease
This trial is testing a new investigational treatment called TRX103 for adults with moderate to severe Crohn's disease that has not responded to at least two other advanced therapies. The study aims to see if this treatment can reduce inflammation and improve symptoms.
Scottsdale, ArizonaAges 18–65 - NCT06631586RecruitingPhase 2
Microbiota transplant for Crohn's disease
This study tests if a standardized fecal transplant is safe and helpful for adults with moderately to severely active Crohn's disease who are already on maintenance therapy. The goal is to see if this treatment can reduce inflammation in the digestive tract.
Minneapolis, MinnesotaAges 18–89 - NCT06520397RecruitingPhase 4
Combination therapy vs. higher dose ustekinumab for Crohn's
This trial tests whether a combination of two drugs (upadacitinib and ustekinumab) works better than a higher dose of ustekinumab alone for people with active Crohn's disease that hasn't responded well to previous treatments.
Guangzhou, GuangdongAges 18–70 - NCT06165289Enrolling by invitation
Balloon dilation with PRP for Crohn's colon narrowing
This trial tests whether adding a platelet-rich plasma (PRP) injection to the standard balloon dilation procedure can help treat a narrowed section of the colon caused by Crohn's disease. It may offer a way to avoid or delay surgery for some patients.
Guangzhou, GuangdongAges 18 years+ - NCT05387031Recruiting
Ustekinumab for painful Crohn’s bowel narrowing
This trial tests ustekinumab, a medicine that calms immune inflammation, to see if it can improve symptoms in people with Crohn’s disease that causes bowel narrowing. It may help if your Crohn’s symptoms come from strictures (narrowed areas) seen on scans or endoscopy.
Beijing, Beijing MunicipalityAges 18–65 - NCT05321745Recruiting
Fecal transplant for children with Crohn’s disease
This trial tests whether transferring stool microbes (called fecal microbiota transplantation, or FMT) can improve Crohn’s disease in children who have not gotten better with usual treatments. If you qualify, the study will check symptoms and colon imaging/score changes over the study follow-up.
Wuhan, HubeiAges 2–16 - NCT05043870RecruitingPhase 4
Testing medicines that calm the immune system in kids with Crohn’s
This trial studies a combination of immune-suppressing treatments for children with Crohn’s disease that is not well controlled. It may help reduce inflammation and improve symptoms if you meet the study’s disease-activity and safety requirements.
Shanghai, Shanghai MunicipalityAges 6–18 - NCT04263831RecruitingPhase 1/Phase 2
Low-dose IL-2 to treat Crohn’s disease flare-ups
This trial tests a low dose of IL-2 to reduce inflammation and help control Crohn’s disease symptoms. It’s for people whose Crohn’s disease hasn’t responded to at least one standard treatment or who need steroids to stay under control.
Boston, MassachusettsAges 12–80 - NCT04224558RecruitingPhase 1/Phase 2
Stem cell transplant for hard-to-control Crohn’s disease
This early-phase study tests whether a stem cell transplant can improve Crohn’s disease in teens and young adults whose disease is active and not responding to standard medicines. It may help some people who are not doing well despite several prior treatments, but it also involves intensive study procedures and safety checks.
Los Angeles, CaliforniaAges 13–28 - NCT03219359RecruitingPhase 2
Stem cell transplant using your own cells for Crohn’s flare
This Phase 2 study tests whether a transplant using your own stem cells can calm active Crohn’s disease that hasn’t improved with standard medicines. It may help some people with ongoing inflammation and symptoms after multiple Crohn’s treatments.
New York, New YorkAges 18 years+ - NCT07444060Recruiting
Guselkumab vs Ustekinumab for stricturing Crohn's disease
This study compares two medicines, Guselkumab and Ustekinumab, for people with Crohn's disease that causes narrowing (strictures) in the bowel. It aims to find which works better to improve symptoms and avoid the need for more procedures.
Hangzhou, ZhejiangAges 18–80 - NCT06958536RecruitingPhase 2
Study of brivekimig for moderate-to-severe Crohn's disease
This trial tests a new medicine called brivekimig for people with moderate-to-severe Crohn's disease. It aims to see if the drug can reduce symptoms and inflammation better than standard treatments.
Tucson, ArizonaAges 18–75 - NCT05683730Recruiting
Intermittent calorie restriction for mild to moderate Crohn’s
This trial studies whether planned periods of eating fewer calories can help people with mild to moderate Crohn’s disease. It requires stable Crohn’s treatment and monitoring for weight and health changes during the study.
Vandœuvre-lès-Nancy, CHRU de NancyAges 18–65 - NCT07531342Recruiting
Brain Stimulation and Diet for Severe Crohn's Disease
This study tests whether repetitive transcranial magnetic stimulation (a non-invasive brain treatment) combined with an anti-inflammatory diet can help people with severe, treatment-resistant Crohn's disease feel better. The brain stimulation uses magnetic pulses on the scalp to reduce inflammation and improve symptoms.
Giza, Giza GovernorateAges 40–60
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Common questions
- Are there clinical trials for crohn's disease, active?
- Yes. Clin2 currently lists 198 recruiting crohn's disease, active studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a crohn's disease, active trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a crohn's disease, active trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.