Clinical trials
Active Surveillance clinical trials
Below are recruiting active surveillance clinical trials, each written for real people, not researchers. We’re tracking 67 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07023432RecruitingPhase 2
Belzutifan vs. watchful waiting for slow-growing kidney cancer
This trial compares two approaches for people with slow-growing, metastatic clear cell kidney cancer: taking a daily pill (belzutifan) or monitoring the cancer closely without treatment. The goal is to see if starting treatment early can help control the cancer longer than waiting.
Houston, TexasAges 18 years+ - NCT02971085Recruiting
Registry for prostate cancer on active surveillance
This study follows men with low-risk prostate cancer who choose active surveillance (watching closely instead of immediate treatment). It aims to better track which monitoring results stay reassuring over time, and when treatment might be needed.
SeoulAges 40–80 - NCT05840484Recruiting
Monitoring study for men on active surveillance
This trial follows men with prostate cancer who choose “active surveillance” instead of immediate treatment. It tests whether careful tracking (including patient reports) can help manage cancer over time and guide decision-making.
Houston, TexasAges 18 years+ - NCT05810467Recruiting
Active surveillance study for men at higher risk prostate cancer
This trial studies how well “active surveillance” works for men with prostate cancer who are considered higher risk because of family history or genetics. It aims to safely monitor the cancer and decide the best timing for treatment if needed, while tracking side effects and follow-up success.
Sutton, SurreyAges 18 years+ - NCT06343077RecruitingPhase 2
Hiltonol injection for prostate cancer on active surveillance
This trial tests a drug called Hiltonol (Poly-ICLC) given directly into the prostate tumor along with an injection under the skin. It is for men with low-risk prostate cancer who are on active surveillance, to see if the drug can slow or stop the cancer from growing.
New York, New YorkAges 18 years+ - NCT03804320Recruiting
Watching small kidney tumors over time instead of treating
This study follows people with small, solid kidney tumors using active surveillance (regular monitoring) rather than immediate surgery or treatment. It may help you understand whether careful watching is a safe option for certain early kidney tumors.
MilanAges 50 years+ - NCT06537154RecruitingPhase 2/Phase 3
Neoadjuvant therapy for bladder cancer with active surveillance
This trial tests whether people with muscle-invasive bladder cancer can safely avoid immediate surgery or radiation after a short course of chemotherapy. Instead, they would be closely monitored and only treated if the cancer comes back.
Vancouver, British ColumbiaAges 19 years+ - NCT02609685Recruiting
Active monitoring for tiny papillary thyroid cancer
This study looks at whether closely watching (without immediate surgery or treatment) a very small thyroid cancer can be safe. You may benefit by avoiding unnecessary procedures, while the team monitors your thyroid and any changes over time.
Los Angeles, CaliforniaAges 18 years+ - NCT00949819Recruiting
Active surveillance study for localized prostate cancer
This trial studies a “watchful waiting” approach, where doctors closely monitor certain prostate cancers with regular checkups and repeat biopsies. It may help people avoid or delay treatment side effects while watching for signs the cancer needs treatment.
Los Angeles, CaliforniaAges 30–85 - NCT07370675Recruiting
Active surveillance for Bethesda IV thyroid nodules
This study is testing whether it is safe to simply monitor (watch closely) a small thyroid nodule that has a certain biopsy result (Bethesda IV) instead of removing it right away. You would not receive a treatment, but would have regular checkups and ultrasounds to see if the nodule changes.
CopenhagenAges 30 years+ - NCT06336187Recruiting
Active monitoring for small kidney tumors
This study tests whether closely monitoring small kidney tumors (less than 4 cm) with regular imaging is a safe and effective option for people who cannot or choose not to have immediate treatment. It involves a biopsy at the start to confirm the tumor type.
NovaraAges 18 years+ - NCT07351461Recruiting
Anxiety in men on active surveillance for early prostate cancer and their partners
This study looks at anxiety levels in men who have chosen active surveillance for early prostate cancer, as well as in their partners or significant others. It aims to understand how this approach affects emotional well-being.
LilleAges 18 years+ - NCT05940415Recruiting
Active surveillance without prostate biopsy for low-risk suspects
This study checks whether people with a low chance of prostate cancer can be monitored closely without having an immediate prostate biopsy. It uses PSA blood tests and prostate MRI to sort who may safely wait.
Hefei, AnhuiAges 18 years+ - NCT07669298Recruiting
Monitoring vs chemoradiation for early rectal cancer
This study compares two approaches after early-stage rectal cancer is removed: either careful monitoring or a follow-up treatment with chemotherapy and radiation. The goal is to see which strategy works better to keep the cancer from returning.
LimogesAges 18 years+ - NCT07262138Recruiting
Active monitoring for older women with early breast cancer
This trial studies whether active monitoring (watchful waiting) can be a safe option instead of immediate surgery or other treatments for women 70 and older who have a small, slow-growing type of breast cancer. If you join, you will not have surgery or other treatments right away, but your cancer will be closely watched.
Pittsburgh, PennsylvaniaAges 70 years+ - NCT06097910Recruiting
Watching multiple lung spots over time
This study is for people who have three or more tiny lung spots (called ground-glass nodules or GGNs) that have not changed in at least three months. The goal is to see if carefully monitoring these spots with regular CT scans is a safe and effective approach.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT04558593Recruiting
Watching complex kidney cysts with regular scans
This study monitors people who have complex kidney cysts to see how they should be followed over time and whether it helps guide treatment. You may get regular imaging (scans), and you’ll be asked to complete questionnaires in English or French.
Calgary, AlbertaAges 18 years+ - NCT06282315RecruitingPhase 3
Safety of a new deworming pill for children in Ghana and Kenya
This trial tests how safe and effective a combined albendazole and ivermectin pill is for treating parasitic infections. It is for school-aged children in specific areas of Ghana and Kenya.
Accra, AccraAges 5–17 - NCT07513389RecruitingPhase 2
HPV throat cancer trial skipping radiation with blood tests
This study tests whether patients with a specific type of HPV-positive throat cancer can safely skip radiation after surgery by using blood tests to monitor for cancer recurrence. The goal is to reduce side effects while keeping patients cancer-free.
Charleston, South CarolinaAges 18 years+ - NCT06469424Recruiting
Safety of Tofacitinib in Ulcerative Colitis
This study follows people with moderately to severely active ulcerative colitis who are taking the medication tofacitinib (Xeljanz). It aims to track any safety concerns in a real-world setting, using information already collected in a European registry (UR-CARE).
BonheidenAges 18 years+ - NCT07714018Recruiting
Comparing two weight loss programs for kidney cancer patients
This study tests two different weight loss programs to see which one helps prevent kidney cancer from growing in people with small kidney masses who are under active surveillance. It may help by improving overall health and potentially slowing cancer progression.
Buffalo, New YorkAges 18 years+ - NCT07722741RecruitingPhase 2
Vaccine to prevent liver cancer return after surgery
This trial tests a personalized vaccine plus a booster (IL-12) to see if it can stop liver cancer from coming back after surgery. It compares the vaccine to just watching and waiting.
Atlanta, GeorgiaAges 18 years+ - NCT06358469Recruiting
Vulvar cancer surgery guided by HPV and p53 testing
This trial is for people with early-stage vulvar cancer that can be surgically removed. It looks at the cancer's HPV and p53 status to decide how much tissue to remove, aiming to reduce side effects while keeping the cancer away.
Kelowna, British ColumbiaAges 18 years+ - NCT04052048Recruiting
Active surveillance prostate cancer test registry study
This study enrolls men with low-risk prostate cancer who are either staying on active surveillance or planning surgery soon. It uses a new “SNEP assay” test to help monitor prostate cancer over time and may improve how doctors track risk.
Royal Oak, MichiganAges 40–80
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Common questions
- Are there clinical trials for active surveillance?
- Yes. Clin2 currently lists 67 recruiting active surveillance studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a active surveillance trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a active surveillance trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.