Clinical trials · California
Depressive Symptoms clinical trials in California
We’re tracking 9 recruiting depressive symptoms studies with a site in California — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT07512284RecruitingPhase 2
Mindfulness and Brain Stimulation for Treatment-Resistant Depression
This study combines mindfulness practice with transcranial magnetic stimulation (TMS)—a non-invasive brain stimulation technique—to help people with depression that hasn't improved with antidepressant medications. The goal is to see if adding mindfulness to TMS improves how well the treatment works.
San Diego, CaliforniaAges 18–65 - NCT06080646Recruiting
Depression and Reward Processing Brain Study
This study uses brain scans (MRI) to understand how people with depression process rewards, aiming to identify different depression subtypes. You may join if you have depression or if you are a healthy volunteer.
San Francisco, CaliforniaAges 18–70 - NCT05426967Recruiting
Brain stimulation for depression after mild traumatic brain injury
This trial studies a noninvasive brain treatment (rTMS) to reduce depression symptoms in people with past mild traumatic brain injury from military service. It may help by changing brain activity, while also requiring stable mental health care and regular follow-up.
Palo Alto, CaliforniaAges 18–55 - NCT06223880RecruitingPhase 4
AXS-05 vs Bupropion to prevent depression relapse
This study tests whether a new drug called AXS-05 can prevent depression from coming back, compared to an older drug called bupropion. If you have major depression and are at risk of relapse, this trial may help you stay well.
Oceanside, CaliforniaAges 18–65 - NCT06559306RecruitingPhase 3
Seltorexant for depression with insomnia symptoms
This trial tests if adding seltorexant to your current antidepressant can improve depression and sleep problems. It is for people with major depressive disorder who still have symptoms, especially insomnia, despite trying at least one antidepressant.
Anaheim, CaliforniaAges 18–74 - NCT06547489RecruitingPhase 2
Testing zelquistinel for major depression
This study tests whether zelquistinel, an investigational drug, can reduce symptoms of major depressive disorder (a type of clinical depression). It is for people who are currently experiencing a moderate to severe depressive episode and are not taking other antidepressants.
Encino, CaliforniaAges 18–64 - NCT07115329RecruitingPhase 2
Testing Zelquistinel for major depression
This study tests a new oral medication called Zelquistinel (taken as a tablet) against a placebo for treating major depressive disorder. Researchers want to see if it can reduce depression symptoms, especially when other antidepressants haven't been tried or haven't worked.
Montclair, CaliforniaAges 18–64 - NCT06073886RecruitingPhase 2
Better brain stimulation for long-lasting concussion symptoms
This trial tests whether personalized brain stimulation can help people who have ongoing symptoms more than 20 on a standard concussion scale, such as headaches, dizziness, or trouble concentrating, after a mild head injury in the past year.
Westwood, Los Angeles, CaliforniaAges 18–65 - NCT07484217RecruitingPhase 3
Testing solriamfetol for depression with daytime sleepiness
This study tests if the drug solriamfetol can help people with major depression who also feel very tired during the day. It aims to improve both mood and daytime sleepiness.
Bellflower, CaliforniaAges 18–65
Depressive Symptoms trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting depressive symptoms studies listed above.
- Research Site · 3 studies
- Anderson Clinical Research · 2 studies
- Clinical Research Site · 2 studies
- Excell Research Inc · 2 studies
- Lumos Clinical Research Center · 2 studies
- Sunwise Clinical Research · 2 studies
- Axiom Research
- Behavioral Research Specialists, LLC
What taking part in a depressive symptoms study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Depressive Symptoms trials in other states
Common questions
- Are there depressive symptoms clinical trials in California?
- Yes. We're currently tracking 9 recruiting depressive symptoms studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depressive symptoms study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depressive symptoms trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depressive symptoms studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.