Clinical trials
Gender Affirmation Surgery clinical trials
Below are recruiting gender affirmation surgery clinical trials, each written for real people, not researchers. We’re tracking 14 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07324967Recruiting
Counseling for transmasculine patients before gender-affirming surgery
This study tests a counseling approach to help transmasculine and non-binary people prepare for a hysterectomy (removal of the uterus) as part of gender-affirming care. The goal is to see if this counseling improves knowledge and decision-making.
Minneapolis, MinnesotaAges 18–65 - NCT04979338RecruitingPhase 3
Opioid-sparing pain control for gender-affirming surgery
This Phase 3 study tests ways to manage pain during and after gender-affirming surgery while using less opioid medicine. It may help improve comfort after surgery and reduce opioid-related side effects.
Los Angeles, CaliforniaAges 18 years+ - NCT04993469Recruiting
Tracking genital comfort after gender-affirming surgery
This study asks people who are planning genital gender-affirming surgery to report how their genital sensitivity and sexual function feel afterward. It helps doctors understand what changes patients experience and improve follow-up care.
Ghent, East-FlandersAges 18–110 - NCT07131267Recruiting
Study on sexual health in trans men during transition
This study aims to understand how sexual function changes for trans men as they go through the gender affirmation process. The results could help doctors provide better support for your sexual health during your transition.
Eskişehir, TürkiyeAges 18–65 - NCT06443164Enrolling by invitation
Chronic Pain Treatment Before Gender-Affirming Surgery
This study tests a one-session pain management class called Empowered Relief for people with chronic pain who are planning gender-affirming surgery. The goal is to see if learning these skills before surgery helps with pain afterward.
Portland, OregonAges 18–100 - NCT06436560Enrolling by invitation
Support for transgender and non-binary people seeking vaginoplasty
This study tests a virtual peer support program for transgender and non-binary people who are planning to have vaginoplasty. It aims to see if talking with a trained peer can help with the process.
San Francisco, CaliforniaAges 18 years+ - NCT05587751Recruiting
Testing how gender-affirming care affects lung function
This study checks whether gender-affirming treatments change breathing/lung test results over time. It may help doctors understand any lung-related effects for transgender and gender-diverse people.
Rochester, MinnesotaAges 14 years+ - NCT07147166Recruiting
Testing a device to prevent raised scars after top surgery
This study tests a special bandage-like device (Brijjit) that may help reduce thick, raised scars after gender-affirming mastectomy (top surgery). If you are having double incision top surgery and want to see if this device can give you flatter, less noticeable scars, this trial may be a good fit.
San Francisco, CaliforniaAges 19 years+ - NCT05318755Recruiting
Gender-affirming hormone therapy study for adults starting care
This study looks at starting gender-affirming hormone therapy (GAHT) for transgender people who have never had these treatments before. It may help you learn whether this approach is safe and effective for your goals as you begin care.
Beijing, Beijing MunicipalityAges 18–40 - NCT07286123Recruiting
Vaginoplasty using fish skin graft for transgender women
This trial tests a new surgical technique for gender-affirming vaginoplasty that uses a fish skin graft (Kerecis) to create the vaginal lining. It may be an option for transgender women planning this type of surgery for the first time.
Cleveland, OhioAges 19–99 - NCT06807580RecruitingPhase 2
Adding progesterone to gender-affirming hormone therapy: a study for transgender women
This study tests whether adding progesterone to your current hormone therapy helps transgender women feel better and more satisfied with their treatment. It might be a good fit if you've been on hormones for at least 6 months and haven't used progesterone before.
Atlanta, GeorgiaAges 18–60 - NCT05794321RecruitingPhase 2
IV tranexamic acid during gender-affirming chest surgery
This Phase 2 study tests whether giving tranexamic acid through a vein during gender-affirming mastectomy can safely reduce bleeding. It may help lower blood loss and related complications during surgery.
San Francisco, CaliforniaAges 18 years+ - NCT06502353Recruiting
Plexaa before gender-affirming mastectomy
This trial tests a product called Plexaa, which is applied before surgery to help prepare the skin and improve healing. It is for transgender or non-binary people having a specific type of mastectomy (breast removal) for gender affirmation.
Palo Alto, CaliforniaAges 18 years+ - NCT07148921Recruiting
Pain perception during gender affirming hormone therapy
This study looks at how starting gender affirming hormone therapy may change your experience of pain. If you are an adult assigned female at birth planning to start testosterone, or an adult assigned male at birth planning to start estradiol, and you have not taken any sex hormones in the past six months, this trial wants to measure your pain perception over time.
Vienna, State of ViennaAges 18 years+
Hear when a new Gender Affirmation Surgery trial opens
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Common questions
- Are there clinical trials for gender affirmation surgery?
- Yes. Clin2 currently lists 14 recruiting gender affirmation surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a gender affirmation surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a gender affirmation surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.