Clinical trials
Harm Reduction clinical trials
Below are recruiting harm reduction clinical trials, each written for real people, not researchers. We’re tracking 25 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06823453Recruiting
Training friends and family to support people who use opioids
This study trains friends and family members of people who use opioids, so they can provide better support and reduce stigma. It also includes people who use opioids to see if this training improves their relationship and well-being.
Chicago, IllinoisAges 18 years+ - NCT07218562Enrolling by invitationPhase 2
Peer training to reduce burnout in harm reduction work
This trial tests whether a training program called PATH can help reduce burnout among peer support specialists and administrators who provide harm reduction services, like syringe or outreach programs.
Chicago, IllinoisAges 18 years+ - NCT07157540Enrolling by invitation
Testing Cann'App for cannabis harm reduction
This study is testing a smartphone app called Cann'App to help people who use cannabis reduce related harms. It's only for people who are already in a larger cannabis study in Lausanne, Switzerland.
Lausanne, Vaud CantonAges 18 years+ - NCT07170072Recruiting
Shelter Harm Reduction Program Study
This study looks at a program called the Shelter Harm Reduction Program (HRSP) in New York City shelters. It aims to see if the program helps people who use drugs and stay in shelters. Researchers will interview people who have stayed in these shelters to learn about their experiences.
New York, New YorkAges 18 years+ - NCT04351958Enrolling by invitation
AR videogame to prevent alcohol use in teens
This trial tests whether an augmented-reality (AR) videogame can help teens avoid drinking and reduce harm from alcohol. If you’re 16–18 and in high school, you may be asked to play the AR game during short sessions to see how well it works.
New Haven, ConnecticutAges 16–18 - NCT07142668Recruiting
How cigarette cost and availability affect tobacco buying
This study looks at how changing cigarette prices and availability affects what and how much tobacco people buy. It may help inform future policies that aim to reduce smoking.
Buffalo, New YorkAges 21 years+ - NCT05516069Recruiting
Using a self-serve kiosk to test for HIV and reduce harm
This study tests an interactive, self-serve machine (kiosk) to help people access HIV testing and other harm-reduction services more easily. It may help by making testing and support more private and simpler to use.
Moncton, New BrunswickAges 16 years+ - NCT06702007RecruitingPhase 3
E-help for reducing alcohol harm
This study tests a program that helps reduce harm from drinking for people in Housing First. It uses electronic tools and support to help you cut back safely.
Seattle, WashingtonAges 21 years+ - NCT05776316Recruiting
Harm-reduction support for adults using opioids
This trial offers harm-reduction services for adults who have been misusing opioids (and sometimes other substances) recently. It’s designed to test support approaches that may reduce risks and improve well-being.
New Haven, ConnecticutAges 18 years+ - NCT06372899Recruiting
Switching to E-cigarettes or Nicotine Pouches for Smokers
This study tests whether switching to e-cigarettes or nicotine pouches can help smokers who have tried many times to quit. If you are a heavy smoker (at least 5 cigarettes a day) and have failed to quit before, this trial may offer a new way to reduce harm from smoking.
Philadelphia, PennsylvaniaAges 21 years+ - NCT05815199Recruiting
E-cigarettes to help smokers with serious mental illness cut down
This study tests whether e-cigarettes can help people who smoke a lot reduce cigarette use (without requiring them to quit completely). It is designed for adults with serious mental illness and focuses on harm reduction and follow-up over time.
New York, New YorkAges 21 years+ - NCT07512856Recruiting
Support Service for Transgender People Using Substances
This study tests a new support program designed specifically for transgender people who use drugs or engage in chemsex (using drugs during sexual activity). The program aims to reduce health risks and provide safer, more culturally respectful care.
Pathum Wan, BangkokAges 18 years+ - NCT07509853Recruiting
Pleasure-Focused Harm Reduction for Chemsex and Substance Use
This study explores how adding conversation about sexual pleasure to harm reduction services can help men who have sex with men and transgender persons who use drugs during sex or use other substances. If you join, you may learn new ways to reduce risks while still enjoying your sex life.
Pathum Wan, BangkokAges 18 years+ - NCT07512869Recruiting
Harm Reduction Support for Men Who Have Sex With Men in Bangkok
This study explores ways to support men who have sex with men (MSM) in Bangkok who use drugs during sexual activities, called 'chemsex.' Researchers want to understand how community leaders, healthcare workers, and police can work together to keep people safer and healthier.
Pathum Wan, BangkokAges 18 years+ - NCT05897099Recruiting
Telehealth harm-reduction for people at HIV risk
This study tests whether a telehealth program can reduce harm and lower HIV risk by helping with safer syringe use. It may help if you have recent syringe exchange use and are not currently on HIV prevention pills.
Miami, FloridaAges 18 years+ - NCT07039292Enrolling by invitation
Can e-cigarettes help reduce smoking?
This study tests whether e-cigarettes can help people who smoke but have not wanted to use other treatments. If you currently smoke and have declined traditional options like nicotine patches or quitlines, you may be able to join.
Charleston, South CarolinaAges 21 years+ - NCT06118502Recruiting
Adaptive quit-smoking treatment for early relapse
This trial tests a flexible treatment approach for smokers who want to quit and are at risk of relapsing early. It aims to help you stay smoke-free by adjusting the support you get.
Charleston, South CarolinaAges 21 years+ - NCT07199517Recruiting
Helping smokers who aren't ready to quit
This study tests whether switching to a less harmful nicotine product (like a nicotine pouch or e-cigarette) can help people who are not ready to quit smoking reduce their health risks. You would be given a sample of a harm reduction product to try, and researchers will check how it affects your smoking habits.
Philadelphia, PennsylvaniaAges 21 years+ - NCT05642715Recruiting
HIV smoking reduction program with varenicline and online support
This study tests a harm-reduction approach to help people with HIV smoke fewer cigarettes and quit if they want, using an online tobacco program and varenicline (a quit-smoking medicine). You may be placed in one of two different study groups to compare how well the approaches work.
The Bronx, New YorkAges 40–79 - NCT05722561RecruitingPhase 2
E-cigarettes to reduce smoking in opioid use disorder
This Phase 2 study tests whether e-cigarettes can help people who use opioids (and also smoke cigarettes) cut down on combustible cigarette smoking. It looks at whether switching to e-cigarettes for “harm reduction” is safe and helps you smoke fewer cigarettes without requiring you to quit completely.
New York, New YorkAges 21–75 - NCT06115746Recruiting
A drug education program for middle and high school students
This study tests a program called iDECIDE, which helps students who have had a substance use issue at school. The program aims to provide education and support instead of punishment. Participants will attend up to 9 online study visits over about a year.
Boston, MassachusettsAges 9–22 - NCT06543407Recruiting
Safer smoking options for people with mental illness
This study offers a way to reduce harm from smoking for people with mental health conditions who are not ready to quit. It tests if switching to a less harmful product can help improve health without requiring you to stop smoking completely.
Louisville, KentuckyAges 21 years+ - NCT06843213Recruiting
Peer-led health resilience program for opioid use disorder
This trial tests a peer-led program to help people with opioid use disorder build resilience and coping skills while they are in the hospital. The program is designed to support recovery and improve health outcomes.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06859710RecruitingPhase 1
THC and CBD as a harm reduction strategy
This study looks at whether different types of cannabis (containing THC and/or CBD) might help people who use cannabis regularly reduce potential harms. You will be asked to take cannabis in a controlled setting and complete tasks and questionnaires.
Los Angeles, CaliforniaAges 21–55
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Common questions
- Are there clinical trials for harm reduction?
- Yes. Clin2 currently lists 25 recruiting harm reduction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a harm reduction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a harm reduction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.