Clinical trials · Massachusetts
HIV clinical trials in Massachusetts
We’re tracking 25 recruiting hiv studies with a site in Massachusetts — including Phase 1, Phase 1/Phase 2, Phase 2 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Massachusetts
- NCT05863923Enrolling by invitation
Text message program to help people with HIV quit smoking
This study tests a texting program that sends messages to help people living with HIV who smoke quit smoking. It may help you reduce tobacco use using regular, motivational text messages.
Worcester, MassachusettsAges 18 years+ - NCT05719441RecruitingPhase 2
Antibodies plus early HIV treatment to try for HIV remission
This study tests whether giving special HIV-fighting antibodies along with starting standard HIV medicine soon after infection can help you reach “HIV remission.” It may reduce or delay the return of detectable virus, but you must be willing to follow close monitoring and specific study steps.
Boston, MassachusettsAges 18–70 - NCT06263426Recruiting
Kidney transplant from donors with HIV: impact on rejection and long-term results
This study tests whether kidney transplants from donors with HIV are safe and effective for people with HIV who need a new kidney. It looks at long-term outcomes like rejection and survival.
Boston, MassachusettsAges 18 years+ - NCT02140255RecruitingPhase 1/Phase 2
Intensive early HIV treatment in newborns to aim for remission
This study gives very early, intensive HIV medicine to infants diagnosed with HIV and follows them closely to see if HIV can go into remission (stop being detectable without ongoing treatment). It may help families understand whether treating right after birth can change a child’s long-term HIV outlook.
Boston, MassachusettsAges Up to 2 days - NCT06088277Recruiting
Texting to reduce HIV risk for dental patients
This study tests if daily text messages can help people lower their risk of getting HIV. You'll receive texts for a few months and complete surveys to see if the messages help.
Boston, MassachusettsAges 18 years+ - NCT07473778Recruiting
Study of Lenacapavir for HIV Prevention
This trial tests a new medication, lenacapavir, to see how well it works for preventing HIV. It is for people who want or need PrEP (a medicine to prevent HIV) and are interested in learning about different options.
Boston, MassachusettsAges 18 years+ - NCT07569029RecruitingPhase 1
HIV vaccine with treatment break to boost immune response
This Phase 1 trial tests two new HIV vaccines (DV700P-RNA and DV701B1.1-RNA) combined with a monitored break from HIV medications in people with well-controlled HIV. The goal is to see if this approach safely strengthens the immune system's ability to fight HIV.
Boston, MassachusettsAges 18–60 - NCT07390955RecruitingPhase 1
Safety study of three anti-HIV antibodies in healthy adults
This study is testing three experimental antibodies (ePGT121v1-LS, PGDM1400LS, and VRC07-523LS) that may help prevent HIV. It’s looking at their safety and how long they stay in the body. Healthy volunteers without HIV can join.
Boston, MassachusettsAges 18–55 - NCT06071767RecruitingPhase 1/Phase 2
Immune therapy trial for early-treated HIV
This study tests whether a combination of three immune therapies can help control HIV without daily medication. You may qualify if you started HIV treatment very early and have had a suppressed viral load for at least a year.
Boston, MassachusettsAges 18 years+ - NCT07390474RecruitingPhase 1
HIV vaccine safety and immune response study for healthy adults
This study tests two experimental mRNA-based HIV vaccines to see if they are safe and create an immune response. It is for healthy adults aged 18 to 55 who do not have HIV.
Boston, MassachusettsAges 18–55 - NCT04430257Recruiting
PrEP for people at higher risk of HIV
This study checks whether taking HIV prevention medicine called PrEP can help protect people who are not living with HIV but have recent risk of HIV exposure. You may qualify if you have ongoing risk and are not already taking PrEP.
Cambridge, MassachusettsAges 18 years+ - NCT05241990Recruiting
Help improve alcohol care for people with HIV in clinics
This study tries a practical clinic strategy to help HIV clinics better offer and carry out alcohol treatment. You may be able to join if you work at the clinic or if you have HIV and your alcohol use screening shows possible unhealthy drinking.
Boston, MassachusettsAges 18 years+ - NCT05570812RecruitingPhase 2
Pregnenolone to improve depressed mood in people with HIV
This Phase 2 trial tests a brain-acting steroid called pregnenolone to help reduce depressed mood. It studies whether it can improve mood in adults with HIV who are already on HIV treatment and still have depression symptoms.
Boston, MassachusettsAges 18–85 - NCT05934305Recruiting
Help for shame and stigma in HIV and substance use
This study tests whether a program can reduce shame and stigma for people living with HIV who also have a substance use disorder. It may help you feel less judged and cope better, while supporting HIV care.
Boston, MassachusettsAges 18 years+ - NCT06001814Recruiting
Mindfulness program for heart health in older adults with HIV
This study tests whether a mindfulness and behavior change program can help older adults with HIV improve their heart health. It combines phone-based coaching and text messages to reduce stress and manage heart risk factors like high blood pressure and diabetes.
Boston, MassachusettsAges 50 years+ - NCT06554717RecruitingPhase 2
Tesamorelin and exercise for physical function in HIV
This study tests whether adding tesamorelin to an exercise program helps older adults with HIV improve their physical function and reduce belly fat. It is designed for people who are mostly sedentary and show early signs of frailty.
Boston, MassachusettsAges 50–80 - NCT06796686RecruitingPhase 1
HIV vaccine safety and immune response study for healthy adults
This trial tests a new two-part HIV vaccine regimen in healthy adults without HIV. The goal is to see if it is safe and produces an immune response that could help prevent HIV.
Boston, MassachusettsAges 18–55 - NCT06856174RecruitingPhase 4
Menopause Hormone Therapy for Women with HIV
This trial tests whether hormone therapy can help manage hot flashes and night sweats in women living with HIV who are going through menopause. It's designed to see if this treatment is safe and effective for this group.
Boston, MassachusettsAges 40–60 - NCT06144229Enrolling by invitation
HPV Vaccine in Women with HIV
This study looks at how well the HPV vaccine works in women living with HIV and whether it helps make cervical cancer screening more accurate. If you are a woman with HIV between 21 and 40 years old and already part of certain other HIV studies, you may be able to join.
Boston, MassachusettsAges 21–40 - NCT07762066Recruiting
Peer support to reduce loneliness and depression in older gay and bisexual men with HIV
This study tests whether meeting with a trained peer supporter can help reduce loneliness and depression in older gay and bisexual men living with HIV. You will be paired with someone who has similar experiences, and together you'll work on building connections and improving your mood.
Boston, MassachusettsAges 50 years+ - NCT05729256Recruiting
Study on alcohol and impulsive sexual choices in gay men
This study looks at how heavy drinking may affect “heat of the moment” sexual decisions and related thinking. You may be able to take part if you meet specific recent sex and drinking criteria.
Boston, MassachusettsAges 18 years+ - NCT06665646RecruitingPhase 1
HIV vaccine booster study for previous trial participants
This study tests a booster vaccine for HIV in people who were part of an earlier HIV vaccine trial. The goal is to see if it's safe and helps the immune system fight HIV better.
Boston, MassachusettsAges 18–60 - NCT06843902RecruitingPhase 2
Improving heart blood flow in women with HIV
This study is testing a medication that may help improve blood flow to the heart in women with HIV who also have diabetes, kidney disease, or protein in their urine. You would need to have a heart scan that shows low blood flow and not be taking certain diabetes drugs.
Boston, MassachusettsAges 45–75 - NCT07032363Recruiting
Depression and HIV treatment support study
This study tests a program that helps people with HIV manage depression and stick to their treatment. It's for adults in Cape Town, South Africa, who have a detectable HIV viral load or may have one, and who show signs of depression.
Boston, MassachusettsAges 18 years+
HIV trials by city in Massachusetts
Where these studies are running in Massachusetts
Institutions with a site for the recruiting hiv studies listed above.
- Massachusetts General Hospital · 9 studies
- Brigham and Women's Hospital · 6 studies
- Fenway Health · 4 studies
- Beth Israel Deaconess Medical Center · 2 studies
- AIDS Action
- Boston Children's Hospital
- Boston Medical Center
- Boston University
What taking part in a hiv study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
HIV trials in other states
Common questions
- Are there hiv clinical trials in Massachusetts?
- Yes. We're currently tracking 25 recruiting hiv studies with a site in Massachusetts, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a hiv study in Massachusetts?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Massachusetts to take part?
- Not necessarily. These studies have a site in Massachusetts, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a hiv trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New hiv studies open in Massachusetts regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.