Pregnenolone to improve depressed mood in people with HIV
Treatments studied
Part of Mental health clinical trials.
This Phase 2 trial tests a brain-acting steroid called pregnenolone to help reduce depressed mood. It studies whether it can improve mood in adults with HIV who are already on HIV treatment and still have depression symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 85 years old
- You have HIV and your viral load is controlled (under 200 copies) while on HIV meds
- You have depressive symptoms (CES-D depression score of 20 or higher)
- You can have an MRI scan and the scan images are likely to be usable
- You have not had certain serious recent infections or unstable medical problems
- You can take pills and complete testing in English
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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