Clinical trials · New York, NY
Major Depressive Episode clinical trials in New York
We’re tracking 37 recruiting major depressive episode studies with a site in or near New York — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near New York
- NCT04041479RecruitingPhase 3
Brain-scan guided rTMS for treatment-resistant depression
This trial tests whether using brain-related “biomarkers” from your scans to guide rTMS can improve depression that hasn’t responded to at least one antidepressant. It may help by targeting brain circuits linked to depression more precisely.
New York, New YorkAges 22–65 - NCT07572526Recruiting
Brain Stimulation to Improve Sleep and Mood in Depression
This study tests a non-invasive brain stimulation technique called tDCS (transcranial direct current stimulation) to see if improving sleep can help reduce depression symptoms. You'll do short stimulation sessions at home and track your sleep and mood.
New York, New YorkAges 18–65 - NCT07592689RecruitingPhase 3
DT120 Treatment for Major Depression
This study tests whether a new medication called DT120 can help people with moderate-to-severe depression feel better. You'd take the medication for several weeks while doctors track your mood and symptoms.
New York, New YorkAges 18–74 - NCT07111390Recruiting
Home-based light therapy for major depression
This trial tests whether a special light you can use at home can help treat major depression. It's a 60Hz light that you turn on and off repeatedly. If you're 24–65, have depression, and take a stable antidepressant, you may be able to participate.
New York, New YorkAges 24–65 - NCT06775379RecruitingPhase 3
Azetukalner vs. placebo for major depression
This trial tests an investigational medication called Azetukalner against a placebo to see if it helps reduce symptoms of major depressive disorder. You may qualify if you are currently in a depressive episode that started in adulthood and have not tried or failed only a few antidepressants.
Brooklyn, New YorkAges 18–74 - NCT07284667RecruitingPhase 2
A new medicine for depression that hasn't improved with other treatments
This trial tests a new medicine called ACP-211 in adults with major depression who have not gotten enough relief from at least two previous antidepressants. The goal is to see if it can help when other treatments have not worked well.
Brooklyn, New YorkAges 18–65 - NCT07172516RecruitingPhase 3
Study of azetukalner vs placebo for bipolar depression
This trial tests whether the study drug azetukalner can help reduce depression symptoms in people with bipolar I or II disorder who are currently having a depressive episode. You would be randomly assigned to receive either the drug or a placebo (inactive pill) to see which works better.
Brooklyn, New YorkAges 18–74 - NCT07196501RecruitingPhase 3
Study of a new add-on treatment for depression maintenance
This trial tests a new medication (NBI-1065845) added to your current antidepressant to see if it helps maintain improvement in depression. It is for people whose depression hasn't fully responded to their current oral antidepressant.
Glen Oaks, New YorkAges 18 years+ - NCT06547489RecruitingPhase 2
Testing zelquistinel for major depression
This study tests whether zelquistinel, an investigational drug, can reduce symptoms of major depressive disorder (a type of clinical depression). It is for people who are currently experiencing a moderate to severe depressive episode and are not taking other antidepressants.
Cedarhurst, New YorkAges 18–64 - NCT06786624RecruitingPhase 3
Testing a new drug for depression that hasn't fully responded to treatment
This trial tests a new medication called NBI-1065845 added to your current antidepressant for people with depression that hasn't fully responded to treatment. It aims to see if this combination can better improve your symptoms.
Mount Kisco, New YorkAges 18 years+ - NCT07095205RecruitingPhase 4
Nicotine's effect on depression in brain imaging study
This trial uses a special brain scan to see how nicotine might help treat depression. It compares people with depression to healthy volunteers to understand how nicotine affects brain chemistry related to mood.
Stony Brook, New YorkAges 18–65 - NCT07076342RecruitingPhase 4
Glutamate receptors and cognitive behavioral therapy for insomnia
This study tests how a brain receptor called mGluR5 affects sleep and depression treatment. You may qualify if you have major depression with insomnia and are not currently on antidepressants.
Stony Brook, New YorkAges 18 years+ - NCT06656416RecruitingPhase 2
ALTO-100 for bipolar depression
This trial tests an investigational drug called ALTO-100 in people with bipolar I or II who are currently experiencing depression. It looks at whether this new medicine can help improve depression symptoms when taken alongside your usual mood stabilizer or antipsychotic medication.
Toms River, New JerseyAges 18–70
Hear when a new Major Depressive Episode trial opens near New York, NY
We’ll email you when one opens near New York, NY — at most once a week, no account needed, unsubscribe anytime.
Where these studies are running near New York
Institutions with a site for the recruiting major depressive episode studies listed above.
- Integrative Clinical Trials · 3 studies
- Neurobehavioral Research Inc · 2 studies
- Neurocrine Clinical Site · 2 studies
- NYU Langone Health · 2 studies
- Stony Brook University Medical Center · 2 studies
- Adams Clinical Harlem
- Richmond Behavioral Associates
- Site 6066
What taking part in a major depressive episode study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting major depressive episode studies in New York.
Common questions
- Are there major depressive episode clinical trials near New York?
- Yes. We're currently tracking 37 recruiting major depressive episode studies with a site near New York, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a major depressive episode study near New York?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in New York to take part?
- Not necessarily. These studies have a site near New York, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a major depressive episode trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New major depressive episode studies open near New York regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.