Clinical trials
Melanoma clinical trials
A serious form of skin cancer that develops in pigment-producing cells. We’re tracking 465 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06214156RecruitingPhase 1/Phase 2
T3011 for advanced melanoma
This trial tests a new treatment, T3011, which is a virus that targets and kills cancer cells while also boosting your immune system. It's for people with advanced melanoma, and the goal is to see if it can shrink tumors and help you live longer.
BeijingAges 18 years+ - NCT07336979RecruitingPhase 2
Chemo plus immunotherapy before surgery for mucosal melanoma
This trial tests a combination of chemo drugs (paclitaxel polymersomes, carboplatin) and an immunotherapy (adebelimab) before surgery for people with mucosal melanoma that can be removed. The goal is to see if this treatment shrinks the tumor and improves outcomes.
Guangzhou, GuangdongAges 18 years+ - NCT07223411Recruiting
Opdualag vs. cemiplimab/fianlimab for melanoma
This trial compares two treatments for advanced melanoma that cannot be removed with surgery or has spread. It studies how these treatments affect the immune response in tumors and blood, and requires extra biopsies and blood draws.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06703398RecruitingPhase 2
Study of GC101 TIL for advanced melanoma
This trial tests a new treatment called GC101 TIL for people with advanced melanoma that has not responded to other therapies. It involves taking immune cells from a tumor, growing them in a lab, and giving them back to fight the cancer.
BeijingAges 18–75 - NCT07281924RecruitingPhase 1/Phase 2
Combination Treatment for Melanoma Spread to Liver
This trial tests a combination of liver-directed chemotherapy (HEPZATO KIT) with a new immunotherapy called Opdualag for people whose melanoma has spread to the liver and who have not had many prior treatments.
Madison, WisconsinAges 18 years+ - NCT07680452Recruiting
High-fiber diet and short-term fasting for melanoma patients on immunotherapy
This trial tests if a high-fiber diet and occasional short-term fasting can help melanoma patients respond better to immunotherapy. It aims to improve treatment outcomes by changing gut health.
Berlin, State of BerlinAges 18 years+ - NCT06081920RecruitingPhase 2
IBI363 for advanced melanoma after standard treatment
This study tests a new drug called IBI363 for people with advanced melanoma that has progressed after standard treatment. It aims to see if IBI363 can shrink tumors or slow their growth.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06627595Recruiting
Exercise and immunotherapy side effects in melanoma
This study looks at whether physical activity can help reduce side effects from immunotherapy in people with melanoma. You may join if you are starting a certain type of immunotherapy for melanoma.
MontpellierAges 18 years+ - NCT03116412Recruiting
Imaging check-ups after melanoma surgery trial
This trial studies whether adding or adjusting imaging scans during follow-up after melanoma surgery can help detect recurrence earlier. It compares different follow-up imaging schedules for people at higher risk after surgery.
BoråsAges 18 years+ - NCT03315468Recruiting
Melanoma patient study in France database
This study collects information from people with melanoma (skin cancer), at any stage. It may help researchers better understand melanoma and improve future care.
NantesAges 18 years+ - NCT03340129RecruitingPhase 2
Nivolumab plus focused brain radiation for melanoma spread
This trial studies whether giving the immunotherapy drug nivolumab together with targeted brain radiation (not whole-brain radiation) helps people with melanoma that has spread to the brain. It aims to improve brain control while keeping side effects manageable.
Sydney, New South WalesAges 18–120 - NCT03563729RecruitingPhase 2
Melanoma in the brain: steroids plus targeted therapy
This Phase 2 trial studies how giving steroid medicine for brain swelling may help people with melanoma that has spread to the brain, and whether adding a targeted approach works for a specific genetic tumor type. It may help shrink brain tumors and improve symptoms, while comparing how patients respond.
Herlev, Capital RegionAges 18 years+ - NCT03842943RecruitingPhase 2
Before-surgery immunotherapy for stage III melanoma
This trial tests immunotherapy given before surgery to help shrink or control stage III melanoma that has spread to nearby areas (lymph nodes/region). If it works, it may improve outcomes after the melanoma is removed.
Louisville, KentuckyAges 18 years+ - NCT03888950Recruiting
Interim PET-CT scan to assess anti-PD-1 treatment in melanoma
This study checks an “interim” whole-body scan (PET-CT) partway through treatment to see how well anti-PD-1 immunotherapy (nivolumab or pembrolizumab) is working for advanced melanoma. It may help doctors better understand early treatment response and guide next steps.
Nice, CHU de NICEAges 18 years+ - NCT03941756Recruiting
Lymph bypass before underarm node surgery to prevent swelling
This study looks at whether adding a lymph “bypass” procedure before underarm lymph node surgery can lower the chance of arm or chest swelling (lymphedema) after cancer treatment. It compares people having lymph node surgery for breast cancer with plans for radiation, and a melanoma comparison group.
Houston, TexasAges 18 years+ - NCT03947385RecruitingPhase 1/Phase 2
First drug test for metastatic uveal melanoma with specific gene changes
This Phase 1/2 trial studies IDE196 in adults with metastatic uveal melanoma that has certain gene mutations or fusions. It’s mainly testing safety and correct dosing, and may help shrink tumors in patients matched to the tumor’s genetic changes.
Los Angeles, CaliforniaAges 18 years+ - NCT04126876RecruitingPhase 2
IMO-2125 skin injection for thick, early-stage melanoma
This trial tests whether an injection given into the skin (IMO-2125) can improve outcomes for people with thicker primary melanoma that has not spread to lymph nodes or other organs. Participants also have planned surgery to remove the tumor and check a sentinel lymph node.
AmsterdamAges 18 years+ - NCT04272658Recruiting
Whole-body PET/CT scan during immunotherapy for melanoma
This trial studies how a whole-body PET/CT scan (using a radioactive sugar called FDG) can better track metastatic melanoma in people receiving immune therapy. It may help doctors understand tumor response to medications like nivolumab or pembrolizumab.
Brest, FinistereAges 18 years+ - NCT04424719Recruiting
Follow-up study for high-risk eye melanoma after treatment
This study follows people with high-risk uveal (eye) melanoma after their initial treatment to better understand relapse risk. It may help your care team track you more closely using scheduled visits and blood tests.
ParisAges 18 years+ - NCT04474301Recruiting
Quality of life check for people with melanoma during COVID-19
This study looks at how people with melanoma are feeling during the COVID-19 pandemic, including quality of life. You may be asked to share information through surveys or study contact so the researchers can understand needs and concerns.
Houston, TexasAges Any age - NCT04493723Recruiting
Biopsies and blood tests for advanced melanoma
This study looks at serial (repeated) tumour biopsies and blood samples in people with advanced melanoma. The goal is to understand biomarkers and disease changes over time, which may help improve future treatment decisions.
ManchesterAges 16 years+ - NCT04567706Recruiting
Melanoma tissue samples storage for future research
This study is about collecting and storing tissue samples from people affected by melanoma so researchers can use them for future studies. It may help speed up research, but it is mainly about sample storage rather than testing a new treatment.
Columbus, OhioAges Any age - NCT04576429Recruiting
Tracking immune changes in melanoma patients on immunotherapy
This trial studies how your immune system “profiles” change while you’re treated with immunotherapy for melanoma. Results may help doctors better understand who benefits from treatment and when.
Boulogne-BillancourtAges 18 years+ - NCT04605146Recruiting
Telemonitoring to manage side effects from immunotherapy
This trial tests whether using home digital monitoring (telemonitoring) can help people with melanoma, lung, or kidney (renal) cancer manage side effects while on immunotherapy. It may help catch side effects earlier and support you during treatment with nivolumab plus ipilimumab or nivolumab alone.
BronAges 18 years+
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Common questions
- Are there clinical trials for melanoma?
- Yes. Clin2 currently lists 465 recruiting melanoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a melanoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a melanoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.