T-Cell Therapy for Advanced Melanoma
Part of Cancer, Immune system & allergy clinical trials.
This trial tests a new T-cell therapy made from your own tumor (TILs), genetically edited to remove the PD1 checkpoint blocker. It may help your immune system fight melanoma that has not responded to standard treatments like anti-PD1 therapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have stage IIIc or IV melanoma that has worsened after standard treatment (like anti-PD1 or anti-CTLA4 therapy).
- You need to have at least one melanoma tumor that can be surgically removed (about the size of a pea or larger).
- Your overall health must be good enough for surgery and chemotherapy – you should be able to do light housework or office work (ECOG 0 or 1).
- Your heart and lung function must be strong – no recent heart attacks, bypass surgery, severe COPD, or uncontrolled asthma.
- You must have adequate blood counts and kidney/liver function (tests will be done to check this).
- If you are of childbearing age, you must use effective birth control during and for some time after treatment.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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