Clinical trials
Muscle Invasive Bladder Cancer (MIBC) clinical trials
Below are recruiting muscle invasive bladder cancer (mibc) clinical trials, each written for real people, not researchers. We’re tracking 37 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06341400RecruitingPhase 1/Phase 2
Combination drug treatment before bladder cancer surgery
This trial tests two drugs (RC48 and toripalimab) given before bladder cancer surgery for patients who cannot take the standard chemotherapy due to kidney problems or other reasons. The goal is to see if this combination can shrink the tumor and improve outcomes.
Guangzhou, GuangdongAges 18 years+ - NCT06263153RecruitingPhase 2
Futibatinib and durvalumab before bladder cancer surgery
This trial tests two drugs (futibatinib and durvalumab) given before bladder removal surgery for people with muscle-invasive bladder cancer who cannot take standard cisplatin chemotherapy. The goal is to see if the combination shrinks the tumor and improves outcomes.
Ann Arbor, MichiganAges 18 years+ - NCT05962541RecruitingPhase 4
Using bladder scans to plan repeat surgery for bladder cancer
This trial checks whether a bladder scan and score (VI-RADS from MRI) can help doctors choose the right way to do a second look surgery for non-muscle-invasive bladder cancer. The goal is to reduce the chance of needing extra (“secondary”) resections while still catching important disease early.
Rome, LazioAges 18 years+ - NCT05833867RecruitingPhase 1
Bladder cancer trial combining radiation and Sacituzumab
This Phase 1 study tests whether a new bladder-cancer treatment plan—radiation given at the same time as sacituzumab govitecan—can help people with muscle-invasive bladder cancer without starting with traditional chemo/radiation. Because it’s early-stage, the main goal is safety and learning the best way to use this combination to preserve the bladder.
Cleveland, OhioAges 18 years+ - NCT05779631Recruiting
MRI test to better stage suspected bladder cancer
This study uses a special MRI scan (mpMRI) to figure out how far suspected muscle-invasive bladder cancer has spread, using a new local staging approach. If the results are accurate, it may help doctors plan the most appropriate curative treatment sooner.
's-HertogenboschAges 18 years+ - NCT05710848RecruitingPhase 1/Phase 2
Study drug for repeat bladder tumor surgery patients
This trial tests STM-416, given around the time you have surgery to remove recurring bladder tumors, to see if it can reduce the chance the cancer comes back. It is for people with high-risk early bladder cancer (non–muscle-invasive) who have already had standard treatment and now need another TURBT.
Mesa, ArizonaAges 18 years+ - NCT05706129RecruitingPhase 1/Phase 2
Testing targeted imaging and therapy for advanced solid tumors
This early-phase study tests two radioactive medicines that first help doctors see tumors and, in some parts of the study, treat them. It may help people with advanced, hard-to-remove cancers that have a specific tumor marker (CA IX).
MelbourneAges 18 years+ - NCT06529822RecruitingPhase 1
Personalized cancer vaccine for solid tumors with residual disease
This trial tests a personalized cancer vaccine designed to help your immune system fight any remaining cancer cells after surgery. It is for people with certain solid tumors—like bladder, stomach, melanoma, or lung cancer—that show signs of disease through a blood test.
Orlando, FloridaAges 18 years+ - NCT07514143Recruiting
Bladder Cancer Detection Study Using Urine Test
This study tests a new urine-based test called EpiCheck to help detect bladder cancer. You'll provide urine samples before or during a bladder procedure you're already scheduled to have, and researchers will see how well the test works.
San Diego, CaliforniaAges 22 years+ - NCT07870577Recruiting
Nerve health during bladder cancer treatment
This study looks at nerve problems (peripheral neuropathy) in people with muscle-invasive bladder cancer who receive a combination of two drugs, enfortumab vedotin and pembrolizumab, before or after surgery. The goal is to understand how these treatments affect nerves and to help manage side effects.
Munich, BavariaAges 18 years+ - NCT06421142Recruiting
FAPI and FDG scans for bladder cancer
This trial is testing if two types of PET/MRI scans (one using FAPI tracer, another using FDG tracer) are better at finding and evaluating muscle-invasive bladder cancer. It may help doctors decide the best treatment for you.
Fuzhou, FujianAges 18–80 - NCT06341478Recruiting
Bladder Cancer Tissue Study in Muscle-Invasive Patients
This study looks at tumor and blood samples from people with muscle-invasive bladder cancer to find markers that help predict how the disease will progress. It aims to improve personalized treatment for those with this specific stage of bladder cancer.
Milan, MiAges 18 years+ - NCT07379281Recruiting
Personalized chemo testing for bladder cancer
This trial tests whether using a patient's own tumor cells grown in a lab (organoids) can help doctors choose the best chemotherapy drugs before bladder cancer surgery. It may help find the most effective treatment for you.
JinanAges 18–80
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Common questions
- Are there clinical trials for muscle invasive bladder cancer (mibc)?
- Yes. Clin2 currently lists 37 recruiting muscle invasive bladder cancer (mibc) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a muscle invasive bladder cancer (mibc) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a muscle invasive bladder cancer (mibc) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Non Muscle Invasive Bladder Cancer
- High Risk Non-muscle Invasive Bladder Cancer
- Non-muscle Invasive Bladder Cancer With Carcinoma in Situ
- Muscle-Invasive Bladder Carcinoma
- Muscle Invasive Bladder Urothelial Carcinoma
- Non-Muscle Invasive Bladder Urothelial Carcinoma
- Non-Muscle Invasive Bladder Neoplasms
- Non-Muscle Invasive Bladder Carcinoma
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.