Clinical trials
Neurotoxicity clinical trials
Below are recruiting neurotoxicity clinical trials, each written for real people, not researchers. We’re tracking 15 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06706102RecruitingPhase 4
Study of Tiny Blood Particles During CAR-T Therapy
This study is for people getting CAR-T cell therapy, a type of cancer treatment that uses your own immune cells. Researchers want to understand a rare side effect called neurotoxicity by looking at tiny particles in your blood called extracellular vesicles.
Saint-EtienneAges 18 years+ - NCT05643092Recruiting
Testing scans and biomarkers for CAR T neurotoxicity risk
This study uses blood tests and brain imaging to better understand and predict nerve-system side effects that can happen after CAR T-cell treatment. It may help doctors spot people at higher risk sooner and guide safer care.
Shijiazhuang, HebeiAges 18–80 - NCT06144151Recruiting
Pupil check to predict CAR-T brain side effects
This study tests if checking your pupil size with a small light device can predict brain-related side effects from CAR-T cell therapy. It is for patients with certain lymphomas receiving axi-cel CAR-T treatment in the hospital.
Houston, TexasAges 18 years+ - NCT07075523Recruiting
Brain scans and markers after CAR T-cell therapy
This study uses brain scans and blood markers to understand how CAR T-cell therapy affects the brain. It may help researchers predict or manage potential side effects.
La Jolla, CaliforniaAges 18 years+ - NCT06895473RecruitingPhase 2
Spinal injection to prevent nerve side effects from CAR-T therapy
This trial tests if a spinal injection of three common chemotherapy drugs can reduce or prevent serious brain and nerve side effects in people receiving CAR-T cell therapy for cancer.
Portland, OregonAges 18 years+ - NCT04986891Recruiting
Study chemotherapy nerve damage in people with no or stable symptoms
This study looks at chemotherapy-related nerve damage (often felt as numbness, tingling, or pain) and why it happens and should matter. You may be eligible if you had a normal nerve check before chemotherapy started, or if your nerve symptoms are stable after finishing treatment.
MonzaAges 18 years+ - NCT05089604RecruitingPhase 4
Compare two tacrolimus forms to reduce tremors after liver transplant
This study compares immediate-release versus extended-release tacrolimus (an anti-rejection medicine) to see if one form causes fewer tremors after a first liver transplant. It may help you and your care team choose the best form if tremors are a problem while your body adjusts after transplant.
Vancouver, British ColumbiaAges 18 years+ - NCT05237986Recruiting
Study brain and thinking effects after CAR T therapy in youth
This study looks at how CAR T-cell treatment affects thinking, learning, and day-to-day brain function in children and young adults with certain blood cancers. You (and a caregiver) may complete online testing so researchers can track these changes over time and whether support is needed.
Los Angeles, CaliforniaAges 5 years+ - NCT05519579RecruitingPhase 2
Spinal chemotherapy to help protect the brain during blinatumomab
This trial studies giving medicine into the spinal fluid (intrathecal chemotherapy) to lower the risk of brain/nerve side effects from blinatumomab. It’s for adults with certain types of B-cell acute lymphoblastic leukemia (ALL) who are starting their first cycle.
Atlanta, GeorgiaAges 18 years+ - NCT05695313RecruitingPhase 2
Prevent nerve damage during weekly paclitaxel breast cancer treatment
This Phase 2 study tests whether a daily tablet (Onlife) can help prevent nerve side effects (“neurotoxicity”) caused by weekly paclitaxel given for breast cancer. You’d be randomly assigned to the tablet or a placebo, and you would be closely followed with questionnaires and clinic visits.
DijonAges 1.5 years+ - NCT06551051RecruitingPhase 2
Duloxetine for nerve damage from ADC cancer treatment
This trial tests whether duloxetine, a medicine often used for nerve pain, can help people whose nerves have been damaged by a type of cancer treatment called an antibody-drug conjugate (ADC). If you have had this side effect and it has not gone away, this study may offer a way to manage it.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06649474Recruiting
Oxaliplatin side effects linked to HMGB1 blood levels
This study checks if a substance called HMGB1 in your blood is linked to nerve damage and liver side effects from the chemotherapy drug oxaliplatin. It is for people with a specific type of stomach or pancreas cancer that can be surgically removed.
Clermont-FerrandAges 18 years+ - NCT07095998Recruiting
Nerve health in people receiving cisplatin chemotherapy
This study looks at how cisplatin affects nerve activity in the arms and legs. It is for people about to start cisplatin, or those who have had nerve symptoms for at least 3 months after finishing cisplatin.
Boston, MassachusettsAges 18 years+ - NCT07173166Recruiting
Managing side effects after CAR-T treatment
This study tests if non-drug approaches like lifestyle changes or supportive care can reduce nerve-related side effects in people with blood cancers who are receiving CAR-T therapy. It aims to help patients feel better during treatment.
Valencia, ValenciaAges 18–80 - NCT07390071Recruiting
Remote rehab program for CAR-T cell therapy patients
This trial tests a home-based rehabilitation program using phone or video sessions to help people with lymphoma or myeloma recover better after CAR-T cell therapy. It aims to improve physical function and quality of life during treatment.
Salt Lake City, UtahAges 21 years+
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Common questions
- Are there clinical trials for neurotoxicity?
- Yes. Clin2 currently lists 15 recruiting neurotoxicity studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a neurotoxicity trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a neurotoxicity trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.