Pupil check to predict CAR-T brain side effects
Part of Brain & nervous system clinical trials.
This study tests if checking your pupil size with a small light device can predict brain-related side effects from CAR-T cell therapy. It is for patients with certain lymphomas receiving axi-cel CAR-T treatment in the hospital.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years old or older.
- You have a type of large B-cell lymphoma (DLBCL, PMBCL, or transformed follicular lymphoma) and are scheduled to receive a CAR-T cell therapy called axi-cel in the hospital.
- You are willing to sign a consent form to participate.
- You have not received CAR-T cell therapy before.
- You are willing and able to have your pupil size measured with a small device called a pupillometer.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study uses a simple iPad test to check for thinking problems that can happen after CAR-T cell therapy. It aims to catch these issues early so they can be managed better.
This study uses blood tests and brain imaging to better understand and predict nerve-system side effects that can happen after CAR T-cell treatment. It may help doctors spot people at higher risk sooner and guide safer care.
This study looks at how thinking and brain function change over time in people with lymphoma who receive CAR T therapy. It may help doctors understand side effects and better support patients during and after treatment.
This study watches patients getting CAR-T cell therapy to see if it affects brain function, thinking, or memory. It aims to find out how common these effects are and help doctors manage them.
This Phase 1 study tests a new type of immune therapy (CAR T cells) placed directly into the fluid around the brain to treat central nervous system (CNS) lymphoma. It mainly looks at safety and how well the treatment can control the lymphoma when other CNS treatments have not worked.
This study looks at how CAR-T cell therapy affects memory and thinking skills in adults with certain types of lymphoma. The results may help doctors understand and support patients better during treatment.
Hear when a new Neurotoxicity trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.