Clinical trials
Opioid Misuse clinical trials
Below are recruiting opioid misuse clinical trials, each written for real people, not researchers. We’re tracking 12 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06200181RecruitingPhase 3
Olanzapine for opioid misuse in cancer pain
This study tests if a medication called olanzapine can help reduce cravings and misuse of opioid pain medicines in people with cancer pain. You would take olanzapine or a placebo daily for a few weeks while continuing your usual care.
Houston, TexasAges 18 years+ - NCT06565416Recruiting
Pain & opioid treatment in Native communities
This study is testing better ways to treat pain and opioid use in Native American communities. It may help if you have chronic pain or struggle with opioids.
Arcata, CaliforniaAges 18 years+ - NCT06292078Recruiting
School program to prevent opioid misuse and exclusion
This trial tests a school-wide program called ISLA that aims to reduce opioid misuse and keep students in school. It will involve all staff and 7th graders at participating middle schools in Oregon.
Capitola, CaliforniaAges 8–15 - NCT06027099RecruitingPhase 3
Testing tizanidine to help reduce opioids after surgery
This study tests whether adding a low-dose muscle relaxant (tizanidine) to your pain plan after surgery can help you safely lower your opioid use. It's for people who have been on long-term opioids and are having surgery at specific hospitals.
Stanford, CaliforniaAges 18–75 - NCT05142267Recruiting
Study stress and opioid-risk factors in chronic low back pain
This study looks at how stress and the body’s natural opioid/cannabinoid systems may relate to risk of opioid misuse. It tests people with long-lasting low back pain to see what biological or psychological factors might increase or lower that risk.
Nashville, TennesseeAges 18 years+ - NCT06084520Recruiting
Pain questionnaire study for opioid and non-opioid patients
This study tests two questionnaires for people with long-term pain. Researchers want to see if the tools work well for both those taking opioids and those who are not. Your answers can help improve pain care.
Uppsala, UpplandAges 18–75 - NCT06387290RecruitingPhase 3
Mindfulness and pain management for chronic pain on opioids
This study tests whether adding mindfulness training to standard pain management visits can help people with chronic pain who are taking long-term opioids. It aims to improve pain relief and reduce opioid-related risks.
La Jolla, CaliforniaAges 18 years+ - NCT06288282Recruiting
Predicting pain and opioid misuse in chronic back pain
This study looks at how thinking and behavior affect long-term pain and opioid use in people with chronic lower back pain. It aims to find better ways to manage pain and prevent medication misuse.
New York, New YorkAges 18 years+ - NCT06288256Recruiting
Spine surgery study: genes, thinking, and pain
This study is for people getting planned spine surgery. It looks at how your genes and thinking skills might affect your pain and use of pain medicine after surgery.
New York, New YorkAges 18 years+ - NCT06526143Recruiting
Pain care pathway for recent veterans
This study tests a new approach to help veterans manage pain in their back, neck, knee, or shoulder after leaving the military. It includes phone or online check-ins and support tailored to your needs.
West Haven, ConnecticutAges 18 years+ - NCT07630428Enrolling by invitation
Support programs after sexual assault medical exam
This study tests two support programs—STAR and TextSTAR—designed to help people after a sexual assault medical exam. The goal is to see which approach better supports your recovery and connects you with resources.
Louisville, KentuckyAges 18 years+ - NCT06320015Recruiting
Peer support for recovery after an emergency visit
This trial tests whether a peer recovery worker can help adults who came to the emergency room for a drug- or alcohol-related problem stay engaged in recovery. If you join, you'll get extra support from someone who has been through similar experiences.
Providence, Rhode IslandAges 18 years+
Hear when a new Opioid Misuse trial opens
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Common questions
- Are there clinical trials for opioid misuse?
- Yes. Clin2 currently lists 12 recruiting opioid misuse studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid misuse trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid misuse trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.