Clinical trials
Analgesics, Opioid clinical trials
Below are recruiting analgesics, opioid clinical trials, each written for real people, not researchers. We’re tracking 21 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07750639Enrolling by invitationPhase 4
Reducing painkiller use after hand surgery
This study tests a new approach to prescribing fewer opioid pain pills after hand, wrist, or elbow surgery. It aims to help reduce the risk of opioid misuse while still controlling pain after surgery.
Orlando, FloridaAges 18 years+ - NCT06590714Recruiting
Polmacoxib for pain after rotator cuff surgery
This trial tests if Polmacoxib, an anti-inflammatory drug, can reduce the need for stronger painkillers after rotator cuff surgery. It may help manage pain with fewer side effects.
Uijeongbu-si, Gyeonggi-doAges 18 years+ - NCT06275191Enrolling by invitation
Testing non-opioid pain relief after tooth extraction
This trial tests whether alternative pain treatments can replace opioid painkillers after wisdom tooth or other tooth removal in teens and young adults. It aims to find safer ways to manage dental pain without relying on opioids.
Lexington, KentuckyAges 12–25 - NCT05991687Recruiting
Safe disposal of leftover pain pills after surgery
This trial helps people who are new to opioids learn how to safely dispose of leftover pain medication after outpatient surgery, reducing the risk of misuse.
Ann Arbor, MichiganAges 18 years+ - NCT06507345Recruiting
Non-opioid pain relief after breast surgery
This trial tests whether non-opioid pain medicines can effectively control pain after mastectomy or lumpectomy, allowing you to go home the same day without needing strong opioids.
Montreal, QuebecAges 18 years+ - NCT06380244Recruiting
Pain Relief Without Opioids for Abdominal Surgery
This study tests if a completely opioid-free anesthesia approach works as well as standard general anesthesia for people having laparoscopic or robotic urological surgery. It aims to offer effective pain control without using strong opioid painkillers.
Krakow, Lesser Poland VoivodeshipAges 18–75 - NCT07396753Recruiting
Nerve block to reduce opioid use after kidney donor surgery
This study tests a nerve block called Transversalis Fascia Plane Block to see if it lowers the amount of strong pain medicine (opioids) needed after a kidney donor surgery. It may help you have less pain and fewer side effects.
Istanbul, ZeytinburnuAges 18–80 - NCT06878014RecruitingPhase 4
Morphine for pain relief after hip replacement surgery
This trial tests different doses of morphine given during spinal anesthesia to find the safest and most effective way to control pain after hip replacement surgery. If you are having a total hip replacement, you may be able to join.
Sosnowiec, Silesian VoivodeshipAges 18–75 - NCT05842928Recruiting
Deprescribing risky medicines in older adults with many medications
This study tests a patient-centered plan to safely reduce certain medicines that may cause side effects in older people who take many drugs. It aims to improve safety and comfort by lowering unnecessary use while keeping you well.
BielefeldAges 65 years+ - NCT06994442RecruitingPhase 3
Best pain relief for children on a breathing tube
This study tests adding extra pain medicines (acetaminophen or an NSAID) to usual opioid pain treatment for children on a breathing machine. The goal is to find the safest and most effective way to manage pain.
Little Rock, ArkansasAges 2 months–17 years - NCT05985629RecruitingPhase 4
Numbing shot behind the knee for ACL surgery pain
This study tests whether an extra numbing shot (called IPACK) behind the knee helps reduce pain and the need for strong pain medicine after ACL reconstruction surgery. It's for patients who are having their first ACL surgery and are not using a donor graft.
Maywood, IllinoisAges 16 years+ - NCT06949826RecruitingPhase 4
Buprenorphine for pain after ankle fracture surgery
This trial tests if buprenorphine, a non-opioid pain medicine, works well for people who have not used opioids before. After ankle fracture surgery, you would get buprenorphine instead of stronger opioids to see if it controls pain just as well with fewer side effects.
St Louis, MissouriAges 18 years+ - NCT06571110Recruiting
Acupuncture for opioid pain relief in fibromyalgia
This study tests whether getting real acupuncture helps people with fibromyalgia who are already taking daily opioid pain medicine, compared to fake acupuncture (sham). The goal is to see if acupuncture can improve pain and reduce the need for opioids.
Irvine, CaliforniaAges 18–80 - NCT07323043Recruiting
Comparing tegileridine and sufentanil for cough during anesthesia
This trial tests whether tegileridine causes less coughing than sufentanil when given as part of anesthesia for surgery. It aims to find a better painkiller option for patients having surgery with a breathing tube.
Lianyungang, JiangsuAges 18–65 - NCT05662371Recruiting
Testing pain-monitor guided pain medicine during robot bowel surgery
This study checks whether using a pain-activity monitor during robot-assisted colorectal surgery can help the surgical team choose the right pain medicine. It may improve comfort and reduce the chance of giving too much or too little pain medicine.
AabenraaAges 18–80 - NCT05722002RecruitingPhase 4
Compare pain-med plans after low-risk surgery
This study tests which pain-medication plan works best and has the fewest side effects after certain low-risk surgeries. You may be assigned to receive opioid-based, NSAID-based, or acetaminophen-based pain control depending on your situation.
Ann Arbor, MichiganAges 18 years+ - NCT06027099RecruitingPhase 3
Testing tizanidine to help reduce opioids after surgery
This study tests whether adding a low-dose muscle relaxant (tizanidine) to your pain plan after surgery can help you safely lower your opioid use. It's for people who have been on long-term opioids and are having surgery at specific hospitals.
Stanford, CaliforniaAges 18–75 - NCT06671002RecruitingPhase 4
Pain medicine safety study for kids having surgery
This study compares different pain medicines to see which works best and is safest for children after surgery for tonsil removal, gallbladder removal, or knee arthroscopy. It aims to help find the most effective and least risky pain control option.
Los Angeles, CaliforniaAges 12–20 - NCT06821516Recruiting
Comparing two nerve blocks for hip replacement pain
This study compares two different nerve block techniques to manage pain after a total hip replacement. The goal is to find out which method provides better pain relief and recovery.
Istanbul, Türki̇yeAges 18 years+ - NCT06774274RecruitingPhase 4
Ketamine for pain after major orthopedic surgery: drip vs. pump
This study tests two ways of giving a medicine called ketamine to control pain after major bone or joint surgery. One method is a steady infusion (drip) through a vein, and the other is a patient-controlled pump (PCA) that lets you press a button for more medicine when you need it.
Medellín, AntioquiaAges 18 years+ - NCT06992427RecruitingPhase 3
Gabapentin to prevent opioid use for mouth pain during cancer treatment
This trial tests if taking gabapentin during chemoradiation for head and neck cancer can reduce the need for strong painkillers like opioids. It may help manage mouth pain caused by treatment.
Gilbert, ArizonaAges 18 years+
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Common questions
- Are there clinical trials for analgesics, opioid?
- Yes. Clin2 currently lists 21 recruiting analgesics, opioid studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a analgesics, opioid trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a analgesics, opioid trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.