Clinical trials
Opioid clinical trials
Below are recruiting opioid clinical trials, each written for real people, not researchers. We’re tracking 430 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06507345Recruiting
Non-opioid pain relief after breast surgery
This trial tests whether non-opioid pain medicines can effectively control pain after mastectomy or lumpectomy, allowing you to go home the same day without needing strong opioids.
Montreal, QuebecAges 18 years+ - NCT07750639Enrolling by invitationPhase 4
Reducing painkiller use after hand surgery
This study tests a new approach to prescribing fewer opioid pain pills after hand, wrist, or elbow surgery. It aims to help reduce the risk of opioid misuse while still controlling pain after surgery.
Orlando, FloridaAges 18 years+ - NCT07427043RecruitingPhase 3
Opioid-free pain plan for robotic prostate surgery
This trial tests a pain management strategy that avoids opioids during and after robotic prostate surgery. It aims to reduce opioid use and side effects while keeping you comfortable.
Boston, MassachusettsAges 45 years+ - NCT07405398Recruiting
Smartwatch study to detect opioid use and withdrawal
This study uses a smartwatch to track wrist data and help detect when someone is using opioids or experiencing withdrawal. It's designed for people with opioid use disorder who are starting or already on treatment with methadone or buprenorphine.
Wilmington, North CarolinaAges 22 years+ - NCT07221786Recruiting
Opioid reduction before spine surgery
This trial tests whether slowly reducing opioid pain medications before spine surgery can lead to a better recovery afterward. It is for adults already taking daily opioids who have major spine surgery planned at least a month away.
Philadephia, PennsylvaniaAges 18 years+ - NCT06651333Recruiting
Brain scans during opioid addiction treatment
This study uses brain scans to understand how methadone or buprenorphine treatment affects the brain, with the goal of helping people stay in treatment and avoid relapse. You would need to be recently started on one of these medications and be able to undergo MRI scans.
Hartford, ConnecticutAges 18–50 - NCT04811014RecruitingPhase 4
Helping young adults stop opioids after an emergency visit
This study offers an engagement program for young people who tested positive for opioids and meet criteria for opioid dependence. The goal is to help participants stop opioid use safely and learn whether this approach works well in the real-world emergency setting.
Houston, TexasAges 13–17 - NCT05854303Recruiting
Stopping opioids’ effects on swallowing in esophagus problems
This study looks at how stopping opioid pain medicines affects esophagus function (the tube that carries food to the stomach), including in people with or without symptoms. It may help researchers understand what changes to expect after opioid cessation in a pain rehabilitation program.
Rochester, MinnesotaAges 18 years+ - NCT05172739RecruitingPhase 4
Opioid-free anesthesia during lung surgery for early lung cancer
This study tests whether an opioid-free pain/anesthesia plan during elective lung surgery can reduce surgical “stress” on the body and affect the immune system. You may be eligible if you have early-stage non-small cell lung cancer and are scheduled for a specific type of surgery (VATS lobectomy).
Heraklion, CreteAges 18–80 - NCT07780097Enrolling by invitation
Starting opioid addiction medication after a hospital stay
This study helps people who are in the hospital for opioid use disorder start a medication like methadone or buprenorphine after they leave the hospital. It aims to make starting treatment easier and improve recovery.
Cincinnati, OhioAges 18 years+ - NCT07693270Recruiting
Study looking for markers of pain and opioid response after injury or surgery
This study is looking for biological markers (like blood tests) that can predict how people will respond to pain and opioids after a traumatic injury or surgery. The goal is to help doctors tailor pain treatment to each person.
La Jolla, CaliforniaAges 18 years+ - NCT07665463Recruiting
Recovery after surgery with or without opioids
This study compares recovery quality after major urological surgery using either opioid-free or opioid-based general anesthesia. It aims to see if avoiding opioids can improve how patients feel after surgery.
Krakow, Lesser Poland VoivodeshipAges 18–75 - NCT07489001Recruiting
Comparing opioid-free to standard anesthesia for back surgery
This study compares two types of anesthesia for lower back surgery: one that uses opioids and one that does not. The goal is to see which approach controls pain better with fewer side effects.
Istanbul, MaltepeAges 18–75 - NCT07466784Recruiting
Opioid use registry for emergency patients
This study is for people who come to the emergency department because of an opioid overdose, withdrawal, or related problem. It will collect information about patients' experiences to help improve care and support for opioid use.
Vancouver, British ColumbiaAges Any age - NCT07342504Recruiting
Brief alcohol support for people on buprenorphine
This trial tests a brief alcohol-focused support program designed for people who are already taking buprenorphine for opioid addiction. The goal is to help you reduce your drinking in a way that fits with your current treatment.
Notre Dame, IndianaAges 18 years+ - NCT06915558Recruiting
Reducing inflammation in weight loss surgery
This trial tests a method to control inflammation during bariatric surgery. It may help patients recover better and have fewer complications.
Barcelona, BarcelonaAges 18–65 - NCT07102446Recruiting
Opioid safety program for chronic pain patients without cancer
This trial tests a program to help manage opioid use safely for people with chronic non-cancer pain. If you take opioids for long-term pain and do not have cancer, this study may help improve your care.
Seoul, SeoulAges 19–79 - NCT07079826Recruiting
Sparrow Link device for opioid withdrawal in hospital
This trial tests a device placed on the ear to help manage opioid withdrawal symptoms in hospitalized adults. It's for people still having withdrawal despite standard medications or those who've chosen not to take methadone or buprenorphine.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06949826RecruitingPhase 4
Buprenorphine for pain after ankle fracture surgery
This trial tests if buprenorphine, a non-opioid pain medicine, works well for people who have not used opioids before. After ankle fracture surgery, you would get buprenorphine instead of stronger opioids to see if it controls pain just as well with fewer side effects.
St Louis, MissouriAges 18 years+ - NCT06872190Recruiting
CDS tool for opioid use disorder in the ED
This trial tests a clinical decision support tool for emergency department providers at UCSF. It helps doctors give better care that considers social needs alongside opioid use treatment. The study will ask providers and patients about how well this tool works.
San Francisco, CaliforniaAges 18 years+ - NCT06823453Recruiting
Training friends and family to support people who use opioids
This study trains friends and family members of people who use opioids, so they can provide better support and reduce stigma. It also includes people who use opioids to see if this training improves their relationship and well-being.
Chicago, IllinoisAges 18 years+ - NCT06731348Enrolling by invitationPhase 4
Pain pill options after pelvic surgery
This trial compares two different amounts of opioid pain pills after surgery for women with pelvic floor problems. The goal is to see if a lower dose still provides good pain relief and keeps patients satisfied.
Bethesda, MarylandAges 18 years+ - NCT06651177RecruitingPhase 2
Tirzepatide with buprenorphine for opioid use disorder
This study tests whether adding tirzepatide, a medication used for weight and blood sugar, to buprenorphine treatment helps people with opioid use disorder. It aims to see if the combination improves outcomes compared to buprenorphine alone.
Jacksonville, FloridaAges 18 years+ - NCT06548490RecruitingPhase 2
Semaglutide for Opioid Use Disorder
This study tests whether a once-weekly injection of semaglutide (a GLP-1 receptor agonist) can reduce opioid use in people who are already on buprenorphine or methadone but still using opioids. It lasts about 19 weeks.
Baltimore, MarylandAges 18–75
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Common questions
- Are there clinical trials for opioid?
- Yes. Clin2 currently lists 430 recruiting opioid studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.