Clinical trials
Opioid Use Disorder clinical trials
Below are recruiting opioid use disorder clinical trials, each written for real people, not researchers. We’re tracking 297 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04978168Recruiting
Peer support and opioid treatment help for people on probation
This study tests whether adding peer recovery support and coordinated opioid treatment support can improve care for people with opioid use disorder (OUD) who are on probation. It also trains and involves probation and treatment staff to better support clients over 12 months.
Durham, North CarolinaAges 18 years+ - NCT05042102RecruitingPhase 2
Donepezil plus brain training for alcohol use disorder
This Phase 2 study tests whether donepezil, along with structured cognitive (brain) training, can improve outcomes for people with alcohol use disorder. It will measure whether this combination helps after recent heavy drinking, while tracking safety over about 13 weeks.
West Haven, ConnecticutAges 18–80 - NCT06160232RecruitingPhase 2
Psilocybin therapy for severe alcohol use disorder
This trial tests whether psilocybin, a psychedelic substance, combined with talk therapy can help people with severe alcohol use disorder stop or reduce drinking. Participants will first complete a 4-week inpatient detox program before receiving psilocybin in a supervised setting.
BrusselsAges 21–64 - NCT06479681Recruiting
Coaching help for alcohol use recovery in hospital
This trial tests if a peer recovery coach can help people with alcohol use disorder stay sober after being hospitalized. You'll get support from someone who has been through recovery themselves.
Greenville, South CarolinaAges 18–75 - NCT07684976Recruiting
Safety of a helmet device using ultrasound for substance use disorder
This study tests a special helmet that uses focused ultrasound to stimulate parts of the brain involved in addiction. It aims to see if the treatment is safe and works for people with moderate to severe substance use disorder who have not gotten enough help from standard medication treatments.
Toronto, OntarioAges 18–70 - NCT07350148Recruiting
Text messages to support opioid medication adherence
This study tests whether daily supportive text messages help people stay on track with their methadone or buprenorphine treatment for opioid use disorder. It is designed for adults who recently started or resumed this medication and have a cellphone.
Albuquerque, New MexicoAges 18 years+ - NCT04616781RecruitingPhase 2/Phase 3
Ketone drink study for alcohol use disorder brain function
This study tests whether a ketone-based treatment (a ketone ester) can change brain activity in people with alcohol use disorder who are not currently seeking treatment. You may also have brain scans, so the study is looking for safe MRI eligibility and certain health factors.
Philadelphia, PennsylvaniaAges 21–65 - NCT05613608RecruitingPhase 2/Phase 3
Cannabidiol (CBD) study for alcohol use disorder
This trial tests whether cannabidiol (CBD) can help people cut down or quit drinking alcohol. It enrolls adults diagnosed with alcohol use disorder and wanting to reduce drinking, while checking for safety and other mental health or drug use factors.
Aurora, ColoradoAges 21 years+ - NCT06063902Enrolling by invitation
Long-term opioid therapy for chronic pain
This study looks at the risks and benefits of long-term use of opioids (strong painkillers) for chronic pain that is not caused by cancer. It aims to help doctors and patients make better decisions about pain management.
UppsalaAges 18 years+ - NCT07214389Recruiting
Measuring outcomes for opioid treatment program quality
This trial is testing ways to improve quality at opioid treatment programs (OTPs). It may help if you receive care at a BayMark OTP.
Research Triangle Park, North CarolinaAges 18 years+ - NCT05675735Recruiting
Methadone take-home program to help people stay in treatment
This trial studies whether changing how methadone is allowed to be taken home can improve how long people stay in opioid use disorder treatment. It focuses on clinics and on adults who have already been receiving take-home methadone.
Storrs, ConnecticutAges 18 years+ - NCT07064564RecruitingPhase 1
Study comparing naltrexone implants with monthly injection in healthy volunteers
This trial compares two forms of naltrexone (a medication used for alcohol and opioid dependence) in healthy volunteers. It tests how well the body processes and tolerates a low or high-dose implant versus the standard monthly injection.
Millcreek, UtahAges 18–65 - NCT07421102RecruitingEarly Phase 1
Mailing buprenorphine after hospital stay
This study tests whether mailing buprenorphine (a medication for opioid use disorder) to patients after they leave the hospital helps them stay on treatment. If you started buprenorphine in the hospital and are heading home to South Carolina, this option might make it easier to continue your recovery.
Charleston, South CarolinaAges 18 years+ - NCT07711795Recruiting
Mindfulness texts for pain and medication
This study tests if text messages with meditation tips and medication reminders can help people with chronic pain stick to their treatment for opioid use. If you recently started or restarted methadone or buprenorphine, this might be for you.
Albuquerque, New MexicoAges 18 years+ - NCT06556602Recruiting
Study to improve access to methadone treatment
This trial tests a new way to help people get methadone treatment by working with staff at opioid treatment programs. It might lead to better access for patients.
Tucson, ArizonaAges 18 years+ - NCT04379115Recruiting
Brain stimulation study for people with opioid addiction
This study tests a non-invasive brain stimulation approach to reduce opioid cravings in people who are actively using non-prescribed opioids while on stable methadone. It may help people feel less craving and improve recovery support.
Hinsdale, IllinoisAges 18–85 - NCT04893525RecruitingPhase 2/Phase 3
Buprenorphine-naloxone microdosing versus standard dosing after ED discharge
This study compares a smaller “microdose” starting method versus the usual starting dose of buprenorphine/naloxone for people with opioid use disorder when they are discharged from the emergency department. It may help find a safer, easier way to start treatment right after an ED visit and avoid problems caused by starting too early.
Calgary, AlbertaAges 18 years+ - NCT05033028RecruitingPhase 3
Using a smartphone to support opioid addiction recovery
This Phase 3 study tests whether using smartphones can help people with opioid-use disorder stick with treatment and recover more successfully. It focuses on people starting or already in treatment using methadone or buprenorphine, with support delivered through the study app or messages.
Piscataway, New JerseyAges 18–85 - NCT05459402RecruitingPhase 2/Phase 3
Methadone dose testing for opioid use disorder pain relief
This study compares taking methadone as one dose versus split into two doses to see which approach works better for people who have pain. It’s meant for adults already on a steady methadone program and who can follow study visits and procedures.
Baltimore, MarylandAges 18–100 - NCT05534815Recruiting
Long-term support for opioid use disorder treatment
This study looks at long-term treatment support for people receiving medicine-assisted treatment for opioid use disorder. It may help by testing an approach to improve long-term outcomes while you receive buprenorphine or methadone.
Marquette, MichiganAges 18 years+ - NCT05579470Recruiting
Study opioid treatment access with staff, patients, and local leaders
This study looks at how to expand opioid addiction treatment in Central Asia by gathering survey and discussion input from people with opioid dependence, people delivering treatment, and local health leadership. It may help improve how treatment programs are set up and delivered in the future.
New Haven, ConnecticutAges 18 years+ - NCT05589181RecruitingPhase 3
High-dose buprenorphine start in the emergency department for fentanyl use
This Phase 3 study tests whether starting a high dose of buprenorphine in the emergency department helps people with opioid use disorder come through withdrawal more safely and effectively. It focuses on people whose urine test shows fentanyl and who are already in withdrawal when they arrive.
Newark, New JerseyAges 18 years+ - NCT05669534RecruitingPhase 4
HIV prevention support for people starting PrEP
This study tests how to better support HIV prevention for people who inject drugs and are newly starting PrEP (medicine to prevent HIV). It focuses on people taking medication for opioid use disorder and who have mild thinking and memory problems, to help them stay safe and adhere to prevention.
New Haven, ConnecticutAges 18 years+ - NCT05769218Recruiting
Rapid HIV prevention and opioid treatment access for people who inject
This study helps people who inject drugs start HIV prevention (PrEP) and medication for opioid use disorder (MOUD) faster. It may reduce HIV risk and improve access to treatment, while the study checks whether the “rapid access” approach works.
Boston, MassachusettsAges 18 years+
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Common questions
- Are there clinical trials for opioid use disorder?
- Yes. Clin2 currently lists 297 recruiting opioid use disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid use disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid use disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.