Clinical trials
Opioid Use Disorder, Moderate clinical trials
Below are recruiting opioid use disorder, moderate clinical trials, each written for real people, not researchers. We’re tracking 87 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04892251RecruitingPhase 1/Phase 2
Ketamine-assisted therapy for opioid use disorder
This trial tests whether ketamine-assisted therapy can help people with opioid use disorder, alongside standard treatment with buprenorphine. It also looks at whether you can safely take part in group mindfulness-style sessions during the study.
Salt Lake City, UtahAges 18 years+ - NCT07810322Recruiting
Testing a new tool to improve treatment connection for opioid use disorder
This study tests a new mobile tool called emPath that helps connect people with opioid use disorder to treatment and support. The goal is to see if using this tool improves how well people stay engaged in care.
Durham, North CarolinaAges 18 years+ - NCT07780097Enrolling by invitation
Starting opioid addiction medication after a hospital stay
This study helps people who are in the hospital for opioid use disorder start a medication like methadone or buprenorphine after they leave the hospital. It aims to make starting treatment easier and improve recovery.
Cincinnati, OhioAges 18 years+ - NCT07631598Recruiting
Buprenorphine at Needle Exchange Programs to Prevent Overdoses
This study tests whether offering buprenorphine (a medication that reduces cravings and withdrawal) directly at syringe service programs (places where people get clean needles) can help people with opioid addiction stay safe and reduce overdose risk. If you use opioids and visit a syringe service program, this may be an option to explore.
Los Angeles, CaliforniaAges 18 years+ - NCT07420283RecruitingPhase 2
Study of Brenipatide for opioid use disorder
This trial tests a new medicine called Brenipatide for people with opioid use disorder who are already taking buprenorphine but still occasionally use non-prescribed opioids. It aims to see if the study drug can help reduce opioid use.
Phoenix, ArizonaAges 18–75 - NCT07362082Recruiting
Telehealth treatment for opioid use disorder
This study tests whether treatment for opioid use disorder can be done effectively through telehealth (video calls and texts). It is designed for people who are not currently on medication for opioid addiction and want to start treatment from home.
New Haven, ConnecticutAges 18 years+ - NCT07278518Recruiting
Emergency department decision aid for buprenorphine
This trial is testing a tool to help people in the emergency department decide whether to start buprenorphine (a medication for opioid use disorder). It's for patients who are not already on medication for their condition.
Charleston, South CarolinaAges 18 years+ - NCT07226570Recruiting
Ibogaine brain mapping study for opioid use disorder
This study uses MRI and EEG scans to map how ibogaine affects the brain in people with opioid use disorder. You must already be scheduled to receive ibogaine treatment in Tijuana, Mexico, on your own, as the study does not cover treatment costs.
Irvine, CaliforniaAges 21–70 - NCT07115030Recruiting
Support program for women with opioid use disorder and past abuse
This trial tests a stepped care program for women who have experienced intimate partner violence and are in treatment for opioid use disorder. It aims to improve recovery by addressing post-traumatic stress symptoms and overall well-being.
Bridgeport, ConnecticutAges 18 years+ - NCT07079826Recruiting
Sparrow Link device for opioid withdrawal in hospital
This trial tests a device placed on the ear to help manage opioid withdrawal symptoms in hospitalized adults. It's for people still having withdrawal despite standard medications or those who've chosen not to take methadone or buprenorphine.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07044466Recruiting
Social functioning study for people in treatment for opioid use
This study looks at how people recovering from opioid use disorder get along with a close friend or family member (called a CSO). It may help improve social support during early treatment.
Charleston, South CarolinaAges 18 years+ - NCT06981195RecruitingPhase 2
Testing lemborexant for insomnia in people on buprenorphine
This study tests if the sleep medication lemborexant can help people with opioid use disorder who also have chronic insomnia. Participants must already be taking buprenorphine (Suboxone) for at least 4 weeks. The goal is to see if better sleep improves mood and reduces opioid use.
Richmond, VirginiaAges 18 years+ - NCT06943859RecruitingPhase 2
Ketamine for opioid use disorder
This study tests whether ketamine, when added to methadone treatment, helps reduce opioid use and cravings. It is for adults with opioid use disorder who are already in a methadone program and have had recent cravings or illicit use. The trial involves multiple visits and follow-up assessments.
Baltimore, MarylandAges 18–65 - NCT06800703Recruiting
Opioid use, pain, and the brain
This study uses brain scans (MRI) to understand how pain affects people with opioid use disorder or regular opioid use, compared to healthy volunteers. It aims to find better ways to treat both pain and opioid addiction.
New Haven, ConnecticutAges 21–60 - NCT06726200RecruitingEarly Phase 1
Comparing buprenorphine formulations for fentanyl addiction
This study tests two different forms of buprenorphine (a medication for opioid addiction) to see which works better for people who use fentanyl or other strong synthetic opioids. If you are seeking treatment for opioid use, this trial may help you find the most effective option.
New York, New YorkAges 18–65 - NCT06718491Recruiting
A smartphone program to reduce heavy drinking for people on opioid treatment
This study tests a brief smartphone-based program to help people reduce heavy drinking while they are receiving medication for opioid use disorder (MOUD). It aims to improve both alcohol and mental health outcomes.
Columbus, OhioAges 18 years+ - NCT06712602RecruitingPhase 1
Testing PT150 for Alcohol Use Disorder
This study tests whether a drug called PT150 can help people with moderate to severe alcohol use disorder who are not currently seeking treatment. You will be asked to stay abstinent from alcohol for short periods and attend sessions to see how PT150 affects your body and alcohol cravings.
Lexington, KentuckyAges 21–55 - NCT06642181RecruitingPhase 1
Guanfacine and meditation with buprenorphine for opioid use disorder
This study tests if adding a medication called guanfacine and mindfulness meditation to standard buprenorphine treatment helps people with opioid use disorder. It looks at whether this combination can improve treatment outcomes and reduce opioid use.
Newark, New JerseyAges 18–55 - NCT06651177RecruitingPhase 2
Tirzepatide with buprenorphine for opioid use disorder
This study tests whether adding tirzepatide, a medication used for weight and blood sugar, to buprenorphine treatment helps people with opioid use disorder. It aims to see if the combination improves outcomes compared to buprenorphine alone.
Jacksonville, FloridaAges 18 years+ - NCT06585709Recruiting
Brain stimulation for opioid use disorder treatment
This trial tests if brain stimulation can help people starting buprenorphine for opioid use disorder. It aims to improve treatment outcomes and support recovery.
Durham, North CarolinaAges 18 years+ - NCT06548490RecruitingPhase 2
Semaglutide for Opioid Use Disorder
This study tests whether a once-weekly injection of semaglutide (a GLP-1 receptor agonist) can reduce opioid use in people who are already on buprenorphine or methadone but still using opioids. It lasts about 19 weeks.
Baltimore, MarylandAges 18–75 - NCT06379984RecruitingPhase 2
Quick-start buprenorphine for opioid addiction with fentanyl use
This trial tests a way to quickly start buprenorphine (a medication for opioid addiction) in an outpatient clinic for people who use fentanyl. It aims to make starting treatment easier and faster, without needing to go through full withdrawal first.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06323837RecruitingPhase 2
Testing mirtazapine for methamphetamine use in people on opioid treatment
This trial tests whether the antidepressant mirtazapine can help reduce methamphetamine use in people who are already receiving medication for opioid use disorder. It aims to see if adding this medication improves outcomes for those struggling with both conditions.
Spokane, WashingtonAges 18 years+ - NCT06316830RecruitingPhase 2/Phase 3
Finding the best buprenorphine dose for opioid use disorder
This trial tests different doses of buprenorphine to find the safest and most effective one for treating opioid use disorder and preventing overdose. It is for people who have used fentanyl and are starting or continuing buprenorphine treatment.
Providence, Rhode IslandAges 18 years+
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Common questions
- Are there clinical trials for opioid use disorder, moderate?
- Yes. Clin2 currently lists 87 recruiting opioid use disorder, moderate studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid use disorder, moderate trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid use disorder, moderate trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.