Clinical trials
Medications for Opioid Use Disorder clinical trials
Below are recruiting medications for opioid use disorder clinical trials, each written for real people, not researchers. We’re tracking 223 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04892251RecruitingPhase 1/Phase 2
Ketamine-assisted therapy for opioid use disorder
This trial tests whether ketamine-assisted therapy can help people with opioid use disorder, alongside standard treatment with buprenorphine. It also looks at whether you can safely take part in group mindfulness-style sessions during the study.
Salt Lake City, UtahAges 18 years+ - NCT07829055Enrolling by invitation
Effects of mental tasks on breathing in chronic opioid users
This study looks at how doing mental tasks affects breathing in people who take opioids daily for chronic pain, compared to those with sleep apnea and healthy people. It may help understand how opioids affect breathing and improve safety.
San Diego, CaliforniaAges 45–65 - NCT07810322Recruiting
Testing a new tool to improve treatment connection for opioid use disorder
This study tests a new mobile tool called emPath that helps connect people with opioid use disorder to treatment and support. The goal is to see if using this tool improves how well people stay engaged in care.
Durham, North CarolinaAges 18 years+ - NCT07800520RecruitingPhase 1
Brain imaging study for people with opioid use disorder
This study uses a special brain scan (PET) and MRI to look at how a protein in the brain, called CB1 (part of the body's natural pain and reward system), changes when people start treatment for opioid use disorder. It may help doctors understand how buprenorphine works and improve addiction treatments.
New Haven, ConnecticutAges 25–65 - NCT07780097Enrolling by invitation
Starting opioid addiction medication after a hospital stay
This study helps people who are in the hospital for opioid use disorder start a medication like methadone or buprenorphine after they leave the hospital. It aims to make starting treatment easier and improve recovery.
Cincinnati, OhioAges 18 years+ - NCT07734623Recruiting
Ultrasound treatment for severe opioid or amphetamine use disorder
This trial tests a low-intensity focused ultrasound treatment for people with severe opioid or amphetamine use disorder. The ultrasound targets a part of the brain linked to addiction, and the goal is to see if it is safe and helpful.
TaipeiAges 20–50 - NCT07711795Recruiting
Mindfulness texts for pain and medication
This study tests if text messages with meditation tips and medication reminders can help people with chronic pain stick to their treatment for opioid use. If you recently started or restarted methadone or buprenorphine, this might be for you.
Albuquerque, New MexicoAges 18 years+ - NCT07693270Recruiting
Study looking for markers of pain and opioid response after injury or surgery
This study is looking for biological markers (like blood tests) that can predict how people will respond to pain and opioids after a traumatic injury or surgery. The goal is to help doctors tailor pain treatment to each person.
La Jolla, CaliforniaAges 18 years+ - NCT07665502Enrolling by invitation
Smartphone app to boost opioid treatment for women facing violence
This study tests a smartphone app (WINGS+++) to help women who have experienced intimate partner violence and trauma improve their engagement with medication for opioid use disorder (MOUD). The goal is to see if the app makes it easier to start and stay on treatment.
New York, New YorkAges 18 years+ - NCT07632053Recruiting
Support Program for Mothers With Opioid Addiction
This study offers support and treatment for mothers struggling with opioid use disorder who have a child age 5 or younger. Researchers will provide intervention and assess brain imaging to understand how best to help mothers and their families.
Ann Arbor, MichiganAges 18–50 - NCT07631598Recruiting
Buprenorphine at Needle Exchange Programs to Prevent Overdoses
This study tests whether offering buprenorphine (a medication that reduces cravings and withdrawal) directly at syringe service programs (places where people get clean needles) can help people with opioid addiction stay safe and reduce overdose risk. If you use opioids and visit a syringe service program, this may be an option to explore.
Los Angeles, CaliforniaAges 18 years+ - NCT07586917Recruiting
Supporting Pregnant People with Opioid Use Disorder
This study helps pregnant people who struggle with opioid use and are starting or considering medication treatment. Researchers will track your health and your baby's health to learn how to best support you during and after pregnancy.
Salt Lake City, UtahAges 18 years+ - NCT05614661Recruiting
Postpartum support for mothers using opioid treatment
This study tests a postpartum intervention for mothers diagnosed with opioid use disorder (or receiving opioid addiction treatment) to help during the period after having a baby. You may be eligible if you have a young child and can complete the study tasks, including possible questionnaires and an MRI if needed.
Ann Arbor, MichiganAges 18–50 - NCT07558187Recruiting
Health Inequalities Study in Rural and Urban Communities
This research study examines how health differences vary between rural and urban areas and among different groups of people. Researchers want to understand what factors affect health outcomes and why some communities experience worse health than others.
LarissaAges 18 years+ - NCT07490717Enrolling by invitation
Treating PTSD and opioid use in jails
This study tests new ways to screen and treat people in jail who have both post-traumatic stress disorder (PTSD) and opioid use disorder. It aims to help participants with therapy while incarcerated and after release.
Little Rock, ArkansasAges 18 years+ - NCT07485335RecruitingPhase 4
Overdose prevention support after emergency department care
This study tests a package of support services to help people who have had an opioid overdose and are starting buprenorphine in the emergency department. The goal is to keep them safe and reduce the chance of another overdose.
Birmingham, AlabamaAges 19 years+ - NCT07466784Recruiting
Opioid use registry for emergency patients
This study is for people who come to the emergency department because of an opioid overdose, withdrawal, or related problem. It will collect information about patients' experiences to help improve care and support for opioid use.
Vancouver, British ColumbiaAges Any age - NCT07421102RecruitingEarly Phase 1
Mailing buprenorphine after hospital stay
This study tests whether mailing buprenorphine (a medication for opioid use disorder) to patients after they leave the hospital helps them stay on treatment. If you started buprenorphine in the hospital and are heading home to South Carolina, this option might make it easier to continue your recovery.
Charleston, South CarolinaAges 18 years+ - NCT05985850RecruitingPhase 2
Can cannabis help with opioid addiction treatment?
This trial tests if adding a specific cannabis product to standard methadone treatment helps people with opioid use disorder. It's for adults over 25 who recently started methadone and have used cannabis before.
Vancouver, British ColumbiaAges 25 years+ - NCT07318480Recruiting
Brain stimulation for drug addiction
This study tests a type of brain stimulation (called tDCS) to help people reduce their use of stimulants (like crack/cocaine) or opioids. It might help lessen cravings and improve treatment outcomes.
New York, New YorkAges 18–60 - NCT07278518Recruiting
Emergency department decision aid for buprenorphine
This trial is testing a tool to help people in the emergency department decide whether to start buprenorphine (a medication for opioid use disorder). It's for patients who are not already on medication for their condition.
Charleston, South CarolinaAges 18 years+ - NCT07232641Recruiting
How pandemic rules affected opioid addiction treatment in the VA
This study looks at how changes in federal and state rules about medications for opioid use disorder during the pandemic affected veterans. It uses information already in your VA records, so there are no extra visits or tests needed.
Boston, MassachusettsAges 18 years+ - NCT07218549RecruitingPhase 1
Study of psychoactive substances in people with past opioid use
This trial tests how safe certain psychoactive substances are and what effects they have in people who have used opioids in the past but are not currently dependent on them. It aims to gather information that could help future treatment options.
Houston, TexasAges 18–55 - NCT07214467Recruiting
Adaptive brain stimulation for opioid use disorder
This study tests a new type of brain stimulation that adapts to your brain activity, aiming to reduce cravings and help you control opioid use. It is for people with long-standing opioid use disorder who have not gotten lasting relief from at least 3 treatment attempts, including medication.
San Francisco, CaliforniaAges 22–75
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Common questions
- Are there clinical trials for medications for opioid use disorder?
- Yes. Clin2 currently lists 223 recruiting medications for opioid use disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a medications for opioid use disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a medications for opioid use disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.