Clinical trials
Osteoarthritis clinical trials
Below are recruiting osteoarthritis clinical trials, each written for real people, not researchers. We’re tracking 612 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04828954Recruiting
Testing different immobilization plans after thumb joint surgery
This study compares different ways of keeping your thumb still (immobilizing it) after thumb base joint surgery. It aims to see which immobilization approach leads to better recovery and hand function.
Chicago, IllinoisAges 40 years+ - NCT03806881Enrolling by invitation
Follow-up after shoulder replacement using a patient-specific implant
This study follows people after a primary or revision shoulder joint replacement when the shoulder socket bone has severe damage. It checks long-term outcomes and how well the patient-specific implant and required therapy work for recovery.
HerentalsAges 18 years+ - NCT07199738Recruiting
Knee replacement study with a new implant option
This study tests a specific knee implant insert (LEGION Medial Stabilized) in people who need a total knee replacement due to arthritis or similar joint disease. It aims to see if the device is safe and works well over time.
Newton, MassachusettsAges 18–80 - NCT05788614Recruiting
Testing shoulder implant movement after reverse shoulder arthroplasty
This study looks at how the shoulder changes position (“reverts”) after a reverse shoulder replacement. It may help doctors better understand what to expect after surgery in people with certain age-related shoulder wear and tear.
Córdoba, CordobaAges 60 years+ - NCT04716803Recruiting
BMAC injection for severe knee osteoarthritis before knee surgery
This trial studies injecting “bone marrow aspirate concentrate” (BMAC) into the knee to help relieve pain from severe knee osteoarthritis. It’s for people who have strong signs of advanced arthritis on X-ray and still have ongoing pain despite usual treatments, before a planned knee procedure.
La Jolla, CaliforniaAges 45–75 - NCT04949087Recruiting
Shoulder arthritis injection study for ongoing pain relief
This trial looks at how well medicine given directly into the shoulder joint reduces pain from primary shoulder osteoarthritis. If you have ongoing shoulder pain confirmed by X-ray, you may be eligible to receive an in-joint injection and be followed for response.
Chicago, IllinoisAges 18 years+ - NCT04074863Recruiting
Surgery for painful wrist-joint arthritis with stable joint
This study looks at a surgical procedure to help people with painful arthritis where two forearm bones meet at the wrist. It’s for people whose joint is stable, aiming to improve pain and hand function.
Lillehammer, OpplandAges 30–75 - NCT03804853Recruiting
Rehab program after reverse shoulder replacement surgery
This trial studies a rehabilitation plan after reverse total shoulder arthroplasty (reverse shoulder replacement) to see if it improves recovery. If you are eligible, you may be guided through specific therapy and follow-up visits as part of the study.
Bloomington, MinnesotaAges 55 years+ - NCT04458584Recruiting
Thumb surgery trial comparing treatments for basal joint arthritis
This study looks at how well different thumb (basal joint) surgery approaches restore strength and function. You would be having planned (non-replacement) thumb surgery, and your chosen surgeon would care for you while researchers compare outcomes.
Lebanon, New HampshireAges 21 years+ - NCT05487274Recruiting
Shoulder arthritis surgery plan for specific shoulder bone alignment
This study compares two types of surgery for advanced shoulder osteoarthritis when the shoulder socket is turned backward more than 15 degrees. It aims to see which surgical approach works best for pain and function when the bone alignment issue can be corrected.
Ottawa, OntarioAges 65 years+ - NCT03017118Recruiting
Turmeric study for early thumb basal joint arthritis
This trial studies whether turmeric can reduce pain from “basal joint” arthritis in the thumb, especially early stages seen on X-ray. You may be a good fit if you’re having thumb base pain and meet specific exam and X-ray requirements.
Boston, MassachusettsAges 40 years+ - NCT03168802Recruiting
Ultrasound and nerve treatment for facet-joint low back pain
This study tests whether a procedure that uses focused ultrasound (MRgFUS) and/or a radiofrequency nerve treatment can reduce long-lasting low back pain caused by facet-joint arthritis. It may help people whose pain improves strongly after a targeted numbing injection to specific back nerves.
Taipei, Please SelectAges 20–79 - NCT04449146Recruiting
Ultrasound guide for shoulder position during standing test
This study uses ultrasound (a non-radiation imaging tool) to help check the best way to hold your shoulder blade while standing. It’s aimed at people having a reverse shoulder replacement on their own shoulder joint, to see if this positioning method can improve care or planning.
BrestAges 18–99 - NCT03404778Enrolling by invitation
Collecting data on reverse shoulder implants for weak rotator cuff
This study collects real-world information about a reverse shoulder implant used when the rotator cuff is badly damaged. It may help improve how these implants are chosen and how well they work for pain relief and improving arm function.
Towson, MarylandAges 18 years+ - NCT06003296Recruiting
Surgery for foot fusion: plate or screw?
This trial compares two ways to join two small bones in the foot during a bigger fusion surgery. It will help find out which method works better and causes fewer problems.
AsyutAges 18–60 - NCT06193057Recruiting
Custom vs standard total ankle replacement trial
This study compares a custom-made artificial ankle joint to a standard one for people with arthritis in one ankle. If you are a candidate for a first-time ankle replacement, this trial could help find out which type of implant works best.
Bologna, BOAges 40–75 - NCT06781554Recruiting
Collagen device for thumb arthritis
This trial tests a new collagen-based medical device injected into the thumb joint to treat thumb base arthritis (rhizarthrosis). It aims to see if it safely reduces pain and improves hand function without surgery.
Milan, MIAges 18–75 - NCT06729983Recruiting
Tendon lengthening during reverse shoulder replacement
This study tests whether slightly lengthening a tendon during reverse shoulder replacement improves outcomes. It's for adults getting their first reverse replacement at Loyola sites.
Maywood, IllinoisAges 18 years+ - NCT07695168Recruiting
Digital course and rehab for knee osteoarthritis
This study tests whether a digital program with special sensors and a digital twin can help reduce knee pain and improve mobility in older adults with knee osteoarthritis. It also includes healthy adults for comparison.
TaipeiAges 20–80 - NCT06025331Recruiting
BIO-RSA vs standard reverse shoulder replacement study
This study compares two types of reverse shoulder replacement: one that uses a bone graft (BIO-RSA) and one that doesn't. It aims to see if the BIO-RSA method gives better pain relief and function for people with arthritis, large rotator cuff tears, or failed prior cuff surgery.
Skien, TelemarkAges 45–80 - NCT06025448Recruiting
Comparing two types of reverse shoulder replacement
This study compares two types of reverse shoulder replacements: one that uses a small piece of your own bone (BIO-RSA) and another that uses a special metal implant (MIO-RSA) to fill the socket. The goal is to see which one stays more stable in the bone after surgery.
OsloAges 45–80 - NCT05992883RecruitingPhase 3
Comparing two injections for thumb arthritis pain
This study tests whether an NSAID injection or a corticosteroid injection works better for thumb base arthritis. If you have ongoing pain despite using things like ibuprofen, ice, or a brace, this trial may help find which treatment offers better relief.
Rochester, MinnesotaAges 40 years+ - NCT05806021RecruitingPhase 4
Tested different cortisone doses for knee osteoarthritis pain
This trial compares different doses of injected cortisone (triamcinolone) directly into the knee to see which dose helps knee osteoarthritis pain most. You may be enrolled in a group receiving a 5 mg, 10 mg, or 40 mg dose if you meet the study’s knee and health requirements.
Montreal, QuebecAges 50 years+ - NCT07023185Recruiting
Cold and compression after knee replacement
This study will test if adding cold and compression therapy after knee replacement surgery can help with pain, swelling, and recovery. You may qualify if you are 50 or older and having a knee replacement with a specific surgeon.
New Orleans, LouisianaAges 50 years+
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Common questions
- Are there clinical trials for osteoarthritis?
- Yes. Clin2 currently lists 612 recruiting osteoarthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a osteoarthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.