Clinical trials
Osteoarthritis clinical trials
Below are recruiting osteoarthritis clinical trials, each written for real people, not researchers. We’re tracking 611 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07231471Recruiting
Platelet-rich plasma for muscle and joint pain
This study tests whether an injection of your own platelet-rich plasma (PRP) can help heal muscle, tendon, or joint problems that haven't gotten better with other treatments like physical therapy or medications.
Salt Lake City, UtahAges 18 years+ - NCT07785401Recruiting
Platelet-rich plasma plus hyaluronic acid for knee osteoarthritis
This study tests whether adding platelet-rich plasma (PRP) to hyaluronic acid injections improves knee osteoarthritis pain and function better than hyaluronic acid alone. You may be eligible if you have moderate knee osteoarthritis and no other knee problems.
Warsaw, Masovian VoivodeshipAges 18 years+ - NCT07784907Recruiting
Platelet-rich plasma and hyaluronic acid for knee arthritis
This trial tests whether a combination of platelet-rich plasma (a concentrate from your own blood) and hyaluronic acid (a joint lubricant) helps reduce pain and improve function in people with knee arthritis. You may be eligible if you have moderate knee pain but your other knee is relatively pain-free.
Chełm, Lublin VoivodeshipAges 18 years+ - NCT04238143Recruiting
Knee and other joint arthritis tissue therapy
This trial tests a regenerative therapy made from a patient’s own fat tissue (a “cellular” treatment) to reduce pain and improve function in arthritis-related problems. It may help people with inflammatory or degenerative arthritis changes, if they meet safety and tissue-donation requirements.
Valencia, CaliforniaAges 18–90 - NCT04814082Recruiting
Compare two knee implant types for walking and function
This study compares two designs of knee replacement implants to see how they affect walking, function, and outcomes after surgery. You may be randomly assigned to one of the implant types used for your specific, approved knee replacement.
Baltimore, MarylandAges 18–75 - NCT06603662RecruitingPhase 4
Steroids for sudden osteoarthritis pain in the emergency room
This trial tests if a short course of oral steroids (glucocorticoids) can relieve sudden osteoarthritis pain in the knee, hip, or shoulder for people who come to the emergency department and are well enough to go home.
York, PennsylvaniaAges 18 years+ - NCT07324746Recruiting
Herbal supplement for osteoarthritis pain
This trial tests whether a herbal supplement helps people with osteoarthritis of the knee or hip feel less pain and move better. If you have moderate to severe pain and are able to walk, this study might be a good fit.
LondonAges 18 years+ - NCT03711773Recruiting
Low-impact exercise classes for joint pain
This study tests a gentle, low-impact exercise program to improve pain and function for adults with knee, ankle, and/or hip pain. You’ll also attend dietitian and behavioral health classes as part of standard care while you participate.
Columbia, MissouriAges 18 years+ - NCT06148779Recruiting
Digital first-line OA treatment for equal access
This study looks at whether a digital program for osteoarthritis (OA) of the hip or knee helps more people get the care they need. It tests if the program works well and is fair for everyone.
MalmöAges 18 years+ - NCT06249958Recruiting
Personalized rehabilitation after hip or knee replacement
This study looks at how personalized rehabilitation after hip or knee replacement surgery can improve your quality of life. It is for people who had their surgery at IRCCS Galeazzi Orthopedic Institute in 2019.
Milan, ItaliaAges 18 years+ - NCT06805188Recruiting
Acupuncture for knee osteoarthritis
This study tests whether acupuncture can reduce pain and improve function for people with knee osteoarthritis. If you have had persistent knee pain and meet the age and health requirements, this treatment may offer relief without surgery or strong medications.
Nanchang, JiangxiAges 18–70 - NCT06859164RecruitingPhase 2
Knee artery treatment for chronic osteoarthritis pain
This trial tests a procedure called genicular artery embolization to reduce pain in people with knee osteoarthritis that hasn't improved with other treatments. The goal is to see if blocking certain blood vessels can relieve pain and help you avoid or delay knee replacement surgery.
Chicago, IllinoisAges 40–80 - NCT07696650Recruiting
Choose to Move Replacement Ready study
This study looks at a program called Choose to Move Replacement Ready (CTM-RR) for older adults and the people who help them get active. It tests how well the program works for activity coaches, participants, and healthcare referral partners.
Vancouver, British ColumbiaAges 50 years+ - NCT07733518Recruiting
Exercise comparison for knee osteoarthritis
This trial compares two types of exercise—eccentric training and low-load blood flow restriction training—to see which is better for reducing pain and improving function in people with knee osteoarthritis.
Rawalpindi, Punjab ProvinceAges 40–70 - NCT07569549Recruiting
Thumb Base Surgery: Joint Replacement vs. Removal Comparison
This study compares two surgical approaches for thumb base arthritis: replacing the damaged joint with an implant or removing the problematic bone. Researchers want to see which approach works better for pain relief and hand function.
ÖrebroAges 40–80 - NCT07417436Recruiting
Graded motor imagery for foot or ankle osteoarthritis
This study tests a technique called graded motor imagery to see if it can reduce pain and improve movement in people with foot or ankle osteoarthritis. The treatment involves specific mental exercises, so it might help if you have chronic ankle pain.
Antalya, AntalyaAges 18 years+ - NCT07112742Enrolling by invitation
Laser and exercise for thumb arthritis
This study tests if a special laser treatment plus hand exercises can reduce pain and improve function in people with thumb arthritis. It compares the laser to a placebo laser, so you won't know which group you're in.
KayseriAges 45–75 - NCT07351968RecruitingPhase 1
Study of HRS-2129 for knee osteoarthritis pain
This trial tests an investigational drug, HRS-2129, for people with knee osteoarthritis who have moderate to severe pain. It aims to see if the drug is safe and effective at reducing pain.
Nanjing, JiangsuAges 18–80 - NCT07217405RecruitingPhase 4
Radiation or steroid shot for hand osteoarthritis pain
This trial compares low-dose radiation therapy to a corticosteroid injection to see which works better for hand osteoarthritis pain. It's for people 50 and older with moderate to severe hand OA who have significant pain when using their hand.
Rochester, MinnesotaAges 50 years+ - NCT07731737Recruiting
Biofeedback vs foam roller for knee osteoarthritis
This trial compares two non-surgical therapies—pressure biofeedback and foam rolling—to see which better reduces pain, improves muscle function, and boosts quality of life in people with early-stage knee osteoarthritis.
LahoreAges 45–65 - NCT07706569Recruiting
Fetuin-A and COMP levels in knee osteoarthritis
This study looks at two substances in the blood (fetuin-A and COMP) to see if they are linked to knee osteoarthritis severity. Results may help understand the disease better.
AntalyaAges Any age - NCT07537153Recruiting
Blocking Blood Vessels to Reduce Knee Arthritis Pain
This trial tests a procedure called genicular artery embolization, which blocks small blood vessels around the knee to reduce pain from moderate arthritis. It may help people whose knee pain hasn't improved with medications.
Chicago, IllinoisAges 40–80 - NCT04137835Recruiting
Noninvasive motion testing for arm and leg function
This study tests how well your upper and lower body moves using non-invasive methods (no procedures or surgery). It’s likely best for healthy adults who can follow instructions and want to help researchers measure movement and function.
Aurora, ColoradoAges 18–65 - NCT04875052Recruiting
Study vibration after ACL injury and future arthritis risk
This study looks at whether using vibration after an ACL injury helps predict or reduce the risk of developing post-traumatic osteoarthritis (wear-and-tear arthritis) later. It may help researchers learn which patients are more likely to develop arthritis after ACL reconstruction.
Chapel Hill, North CarolinaAges 16–35
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Osteoarthritis trials by city
Studies with a site in or near these metro areas.
Osteoarthritis trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for osteoarthritis?
- Yes. Clin2 currently lists 611 recruiting osteoarthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a osteoarthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.