Clinical trials
Pre-Exposure Prophylaxis (PrEP) clinical trials
Below are recruiting pre-exposure prophylaxis (prep) clinical trials, each written for real people, not researchers. We’re tracking 36 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06158607Recruiting
PrEP adherence help for women with substance use
This study tests a program to help Black and Hispanic women with substance use disorders take PrEP consistently to prevent HIV. The goal is to see if talking with a health coach can improve PrEP use and reduce HIV risk.
Houston, TexasAges 18–60 - NCT06408142Recruiting
HIV testing and connection to care in South African ERs
This study tests a program that offers HIV testing and connects people to prevention or care right in the Emergency Department. It aims to make it easier for anyone visiting the ER to get the HIV services they need.
Cape Town, Western CapeAges 12 years+ - NCT06250504RecruitingPhase 3
HIV prevention study for young adults
This study tests a long-acting HIV prevention shot (Cabotegravir) or a vaginal ring (DapiRing) along with sexual health services for young people. It aims to find the best way to prevent HIV and support overall health.
Somkele, KwaZulu-NatalAges 15–30 - NCT06558825Recruiting
PrEP support for women with trauma history
This study tests a program to help women who have experienced trauma and are at risk for HIV start and stay on PrEP (a daily pill that prevents HIV). It looks at whether mental health treatment can boost PrEP use.
Houston, TexasAges 18 years+ - NCT06807736Recruiting
Choosing injectable PrEP for HIV prevention in Cape Town
This study offers three ways to prevent HIV: a shot every two months (injectable PrEP), daily pills, or a vaginal ring. Researchers in Cape Town will help you choose the option that fits your life best.
Cape Town, Western ProvinceAges 15 years+ - NCT06860945Recruiting
Predicting STIs in people on HIV PrEP in Spain
This study is for people in Spain who are starting or already taking PrEP pills to prevent HIV. It aims to create a tool that can help predict who might get a sexually transmitted infection while on PrEP, so doctors can offer better monitoring or prevention.
AlmeríaAges 16 years+ - NCT07029152Recruiting
Anal cancer screening for gay and bisexual men on PrEP
This study is screening gay and bisexual men for anal cancer by taking a swab sample. It aims to find early signs of cancer so it can be treated early.
BrugesAges 35 years+ - NCT07089966Recruiting
PrEP delivery in family planning clinics
This trial tests a program where HIV testing counselors help family planning patients learn about and get PrEP, a daily pill that prevents HIV. It aims to make PrEP easier to access in clinics you may already visit.
KisumuAges 15 years+ - NCT07199335RecruitingPhase 4
Injectable HIV prevention drug for people who inject drugs
This study tests a long-acting injectable medication called cabotegravir to prevent HIV in people who inject drugs. If you have injected street drugs recently, you may be able to get this shot every few months instead of taking daily pills.
Boston, MassachusettsAges 18 years+ - NCT07584122Recruiting
Increasing HIV Prevention Access in Rio de Janeiro
This study helps people at higher risk of HIV get access to PrEP, a daily medication that prevents HIV infection. The program focuses on underserved communities in Rio de Janeiro and aims to make PrEP easier to access and use.
Nova Iguaçu, Rio de JaneiroAges 15 years+ - NCT05492565Enrolling by invitation
Follow-up study for people on HIV prevention pills
This study follows adults who are at high risk of getting HIV while they take HIV prevention pills (PrEP). It aims to learn how well PrEP fits real-life use in people at risk and who may need extra care.
Seville, AndalusiaAges 18 years+ - NCT07397403RecruitingPhase 4
Doxycycline to prevent STIs in men who have sex with men
This trial tests whether taking a single dose of doxycycline after sex can prevent common sexually transmitted infections (STIs) like gonorrhea, chlamydia, and syphilis in men who have sex with men (MSM) in Bangkok.
Sathorn, BangkokAges 3 weeks–2 months
Hear when a new Pre-Exposure Prophylaxis (PrEP) trial opens
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Common questions
- Are there clinical trials for pre-exposure prophylaxis (prep)?
- Yes. Clin2 currently lists 36 recruiting pre-exposure prophylaxis (prep) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pre-exposure prophylaxis (prep) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pre-exposure prophylaxis (prep) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.