Clinical trials
Primary Dysmenorrhea clinical trials
Below are recruiting primary dysmenorrhea clinical trials, each written for real people, not researchers. We’re tracking 28 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06777940Recruiting
Kegel exercises vs. muscle release for period pain
This study compares two methods to reduce period pain: Kegel exercises (pelvic floor exercises) and a hands-on technique to release muscle knots (trigger points) in the lower belly, back, and hip. It may help if you are a young woman with painful periods and have tender spots in those muscles.
Lahore, Punjab ProvinceAges 17–25 - NCT07520136Recruiting
Yoga for Period Pain in Young Women
This study tests whether a structured yoga exercise program can reduce menstrual cramps (period pain) in healthy young women aged 18–25. If yoga helps, it could offer a natural way to manage pain without medication.
AnkaraAges 18–25 - NCT05640232RecruitingPhase 3
Test medicine CDE100 for severe menstrual cramp pain
This Phase 3 study tests whether CDE100 can reduce menstrual cramp pain in people with primary dysmenorrhea (cramps that are not caused by another medical condition). It also checks how safe the treatment is and how it’s tolerated over time.
Hortolândia, São PauloAges 16–35 - NCT06401226Recruiting
Pain and fitness in painful periods
This study looks at how pain and physical fitness are related in people with painful periods. It aims to help us understand the condition better and may lead to new ways to manage period pain.
IstanbulAges 18–25 - NCT07354451Recruiting
Pelvic nerve treatment for period pain
This trial tests a gentle hands-on technique to ease severe period pain by targeting pelvic nerves. It may help if you have very painful periods without another medical cause.
SialkotAges 18–30 - NCT07092878Recruiting
Chamomile and L-theanine drink for period pain
This study tests whether a beverage made from chamomile and L-theanine (a natural ingredient found in tea) can help reduce period pain in young women. It may be a good option if you have moderate to severe cramps and want a natural approach.
Kampar, PerakAges 18–30 - NCT07239232Recruiting
Knee balance and position sense in women with period pain
This study looks at how well young women with painful periods sense their knee position and keep their balance. It may help understand if period pain affects movement and coordination.
GizaAges 18–25 - NCT07618832Recruiting
Mind-Based Pain Relief Training for Menstrual Cramps
This study tests whether a mental training technique called graded motor imagery—where you imagine moving your body in specific ways—can reduce severe menstrual pain. The trial is for women with confirmed primary dysmenorrhea (painful periods without underlying disease) who have altered pain sensitivity.
Lahore, Punjab ProvinceAges 18–30 - NCT07731243Recruiting
Vibration, massage and myofascial release for period pain
This study tests whether combining vibration, massage, and myofascial release (a gentle stretching technique) can help relieve pain from primary dysmenorrhea (period pain without an underlying condition). If you are a woman with regular periods and moderate to severe menstrual pain, this trial may offer a non-drug treatment option.
Istanbul, IstanbulAges 18–30 - NCT06492148Recruiting
Myofascial Release for Period Pain in Women
This study tests a gentle hands-on technique called myofascial release to see if it can reduce period pain in women who have primary dysmenorrhea (painful periods without an underlying condition). If you have moderate to severe cramps and don't use hormonal birth control, you may be able to join.
AnkaraAges 18–35 - NCT06761755Recruiting
Taping and relaxation for period pain relief
This study tests if adding kinesiology tape to the abdomen can help with period pain in young women ages 18-25. It also looks at how relaxation techniques might work together with the tape to reduce pain.
Lahore, Punjab ProvinceAges 18–25 - NCT07391930Recruiting
High intensity exercise for period pain
This study tests if high-intensity interval training (short bursts of intense exercise) can help reduce period pain. It is for people who have not given birth and experience regular period pain.
Alcalá de Henares, MadridAges 18–40 - NCT07647276Recruiting
Massage and relaxation for period pain relief
This study tests whether connective tissue massage (a hands-on technique) and progressive relaxation exercises can reduce severe menstrual cramps. If you have primary dysmenorrhea—painful periods without an underlying medical cause—this trial may help you find natural pain relief.
DenizliAges 18–30 - NCT07263516Enrolling by invitation
Pelvic and breathing exercises for period pain
This study tests whether pelvic floor and diaphragmatic breathing exercises can reduce pain during periods. It is for women with primary dysmenorrhea who have not had a pregnancy or childbirth and are not on regular medications.
Istanbul, AvcılarAges 18–25 - NCT07409337Recruiting
Self-acupressure for period pain and PMS
This trial tests if doing acupressure on yourself can reduce period pain and premenstrual symptoms over about six months. It might help if you have painful periods and are looking for a non-medicine option.
Niğde, MerkezAges 18–30 - NCT07352982Recruiting
Nerve stimulation for painful periods in young women
This study tests if a gentle nerve stimulation device placed near your ankle can reduce period pain. It is for young women with primary dysmenorrhea (painful periods without a known medical cause).
Kafr ash Shaykh, KafrelsheikhAges 20–25 - NCT07209566Recruiting
Muscles, nerves, and period pain in women
This study looks at how your muscles and nervous system relate to period pain. It compares women with and without painful periods to understand why some have more pain.
Azusa, CaliforniaAges 18–35 - NCT07095725Recruiting
Effect of Period Pain on Muscle Activity in Young Women
This trial studies how primary dysmenorrhea (period pain) affects muscle activity in young women aged 18-25. It may help understand why period pain happens and guide future treatments.
GizaAges 18–25 - NCT06316583Recruiting
Dry needling for painful periods study
This trial tests whether dry needling (a type of acupuncture) can help relieve primary dysmenorrhea (painful periods without another cause). It compares the effects on specific acupoints to see which works best.
Beijing, Beijing MunicipalityAges 18–30 - NCT06995287RecruitingPhase 3
Botulinum toxin injection for severe period pain
This trial tests whether injecting botulinum toxin into the uterine muscle during a hysteroscopy can reduce severe period pain or chronic pelvic pain that hasn't improved with standard treatments. It may be an option for women who have tried hormonal therapy and pain relievers without success.
Aix-en-ProvenceAges 18 years+ - NCT06398990Recruiting
Cognitive exercise therapy vs. yoga for teen period pain
This study compares two non-drug treatments—a cognitive exercise therapy approach and yoga—to see which helps reduce pain and improve quality of life in teenagers with period pain. If you are between 10 and 19, have moderate to severe menstrual cramps, and have never given birth, you may be eligible.
Istanbul, AtaşehirAges 10–19 - NCT07754305Recruiting
Breathing and pelvic floor training for painful periods
This study tests a special breathing and muscle training program to see if it can reduce period pain in young women. It may help you manage your symptoms without medication.
Islamabad, Punjab ProvinceAges 18–24 - NCT06741059Recruiting
TENS for period pain relief
This study tests if TENS, a gentle electrical stimulation device, can reduce period pain and related symptoms. If you have painful periods and are not using other treatments, this might be an option for you.
OsmaniyeAges 18 years+ - NCT07022106Recruiting
Comparing physiotherapy techniques for period pain
This study compares different physical therapy techniques to help reduce period pain. It is for people with painful periods (dysmenorrhea) who do not have other gynecological conditions.
Istanbul, BeykozAges 18–30
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Common questions
- Are there clinical trials for primary dysmenorrhea?
- Yes. Clin2 currently lists 28 recruiting primary dysmenorrhea studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a primary dysmenorrhea trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a primary dysmenorrhea trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.