Clinical trials
Primary Open Angle Glaucoma clinical trials
Below are recruiting primary open angle glaucoma clinical trials, each written for real people, not researchers. We’re tracking 58 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07777861RecruitingPhase 2
Testing an eye drop for worsening glaucoma
This study tests an eye drop (G01) for people with primary open-angle glaucoma that is getting worse despite current treatments. It aims to see if G01 can safely slow down or stop the progression of glaucoma.
Beijing, Beijing MunicipalityAges 18–80 - NCT03675412Recruiting
Testing how caffeine affects eyes in glaucoma
This study compares how caffeine changes eye measurements in people with primary open-angle glaucoma versus people without eye disease. It may help researchers understand whether caffeine intake could affect vision-related eye signals.
Philadelphia, PennsylvaniaAges 18–90 - NCT06822738RecruitingPhase 3
Study of XEN63 gel stent for glaucoma patients
This trial tests a new gel stent (XEN63) to lower eye pressure in adults with glaucoma. It compares two ways of putting the stent in the eye, and may help people who have not had success with other treatments.
Glendale, ArizonaAges 45 years+ - NCT03423758Recruiting
Genetic study of eye diseases: PXF, angle-closure and open glaucoma
This study looks at blood or DNA-related factors that may explain why certain glaucoma and related eye conditions happen. It may help researchers understand risk and causes across different glaucoma types.
ViennaAges 21–105 - NCT03870230Recruiting
Study of eye blood-flow signals in glaucoma and healthy eyes
This study compares eye blood-flow/brain-eye communication signals in people with glaucoma (or high eye pressure) versus people with normal eye tests. It may help researchers understand how glaucoma develops and progresses.
ViennaAges 18 years+ - NCT03921931Recruiting
Test retinal responses to light in healthy eyes or eye disease
This is a small pilot study that measures how parts of the retina change before and after light stimulation. It may help researchers understand eye function in people with normal vision or specific eye conditions like glaucoma or dry age-related macular degeneration (AMD).
Vienna, State of ViennaAges 18 years+ - NCT07700498Recruiting
Combined cataract and glaucoma surgery for new patients
This trial tests a single surgery to treat both glaucoma and cataracts at the same time. It is for people who have not had any prior glaucoma treatment and need cataract surgery.
Ningxia, NingxiaAges 40–85 - NCT04553523Recruiting
Hydrus microstent study for open-angle glaucoma with cataracts
This study enrolls people who have cataracts and primary open-angle glaucoma that is being treated with eye drops. It will look at how well the Hydrus microstent works after approval, especially for lowering eye pressure safely.
Irvine, CaliforniaAges 45 years+ - NCT04396002Recruiting
Study of life movement and vision loss in older adults
This study looks at whether how far and how much you move around each day is linked to glaucoma and vision field loss in older adults. It may help researchers understand what affects vision changes over time.
Birmingham, AlabamaAges 18–100 - NCT05039684Recruiting
Testing eye-surface inflammation in glaucoma or high eye pressure
This study measures inflammation markers on the eye surface in people with primary open-angle glaucoma or ocular hypertension who use certain glaucoma drops. The results may help doctors understand how these drops affect the eye and inflammation.
ValladolidAges 18–99 - NCT05264818Recruiting
Study measures eye surface sugar layer in glaucoma
This study looks at a thin “sugar coating” on the inside surface of the eye (the endothelial glycocalyx) in people with primary open-angle glaucoma and compares it with people without optic nerve disease. The results may help researchers better understand how glaucoma affects the eye.
ParisAges 18 years+ - NCT05370287Recruiting
Adaptive-eye imaging for adults with primary open-angle glaucoma
This study uses a special “adaptive optics” camera to take very detailed pictures of the retina (the light-sensing layer at the back of the eye). It is meant for adults with primary open-angle glaucoma to improve how well the images can be captured and studied.
Silver Spring, MarylandAges 21 years+ - NCT05439161Recruiting
XEN gel stent compared with trabeculectomy for open-angle glaucoma
This trial compares two glaucoma operations to see which works better at lowering eye pressure and keeping the eye stable. It’s for adults with open-angle glaucoma who are eligible for either surgery and can attend follow-up visits.
SalzburgAges 18 years+ - NCT05564091Recruiting
Add a minimally invasive canaloplasty step to cataract surgery
This trial compares standard cataract surgery alone versus cataract surgery plus a procedure to improve fluid drainage in the eye. It is intended for people with mild to moderate open-angle glaucoma, to see if adding this step helps control eye pressure and preserve vision.
Sugar Land, TexasAges 55 years+ - NCT05710198RecruitingPhase 3
Citicoline eye drops to slow vision field loss in glaucoma
This Phase 3 trial tests whether citicoline 2% eye drops can help slow worsening of the visual field in adults with open-angle glaucoma. If you qualify, you would be monitored with repeated eye tests to see if your vision field stays more stable over time.
Milan, MIAges 18 years+ - NCT05786196Recruiting
Testing canaloplasty surgery for mild to moderate glaucoma
This study tests how well a specific glaucoma surgery (canaloplasty) works on its own for people with mild to moderate primary open-angle glaucoma. It may help if drops (eye medicines) do not work well for you or you need fewer eye drops.
DüsseldorfAges 22 years+ - NCT05844384Recruiting
Testing a new eye drop bottle for glaucoma
This study checks whether a device called the Nanodropper helps deliver glaucoma medicine as well as standard use. It is for adults with stable primary open-angle glaucoma (or ocular hypertension) who are on a limited number of eye-pressure medicines.
Lackland Air Force Base, TexasAges 18 years+ - NCT06057051Recruiting
Stent implant for mild to moderate open-angle glaucoma
This trial studies a tiny implant called iStent Infinite that helps drain fluid from the eye to lower pressure in people with mild to moderate open-angle glaucoma. It may offer a new way to manage the condition.
Cincinnati, OhioAges 35 years+ - NCT06223048RecruitingPhase 2
Study of AMDX-2011P for primary open angle glaucoma
This trial tests an investigational drug called AMDX-2011P for people with primary open angle glaucoma in both eyes. It aims to see if the drug can help protect the optic nerve and preserve vision.
Phoenix, ArizonaAges 22 years+ - NCT06246136Recruiting
Laser treatment for glaucoma during cataract surgery
This study tests a new laser treatment (ELIOS) for people with open-angle glaucoma who also need cataract surgery. It aims to see if the laser is safe and effective at lowering eye pressure while removing the cataract.
LeuvenAges 40 years+ - NCT06313749Recruiting
Trial of a new surgery for glaucoma not helped by eye drops
This study tests a new minimally-invasive surgery called MIMS to lower eye pressure in people with open-angle glaucoma that isn't well controlled even with multiple eye drop medications. The surgery makes a tiny opening to help fluid drain and reduce pressure in the eye.
Dallas, TexasAges 40–85 - NCT06523751Recruiting
Predicting success of a glaucoma surgery with a quick test
This study tests a new quick procedure called trabeculopuncture to see if it can predict whether a more involved glaucoma surgery (ab interno trabeculectomy) will work for you. If you have a specific type of glaucoma, high eye pressure despite drops, and need cataract surgery, this trial might help lower your pressure and reduce medications.
Würzburg, BavariaAges 18 years+ - NCT06682962Recruiting
Electrical stimulation for vision loss from glaucoma
This trial tests if a gentle electrical stimulation on the eye can slow or improve vision loss in people with open-angle glaucoma. It uses a device you can use at home after training.
MainzAges 40 years+ - NCT06685211Recruiting
Electrical stimulation for vision in glaucoma
This trial tests whether gentle electrical stimulation can help improve vision in people with moderate vision loss from glaucoma. It might offer a new way to strengthen remaining vision.
Palo Alto, CaliforniaAges 18 years+
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Primary Open Angle Glaucoma trials by city
Studies with a site in or near these metro areas.
Primary Open Angle Glaucoma trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for primary open angle glaucoma?
- Yes. Clin2 currently lists 58 recruiting primary open angle glaucoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a primary open angle glaucoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a primary open angle glaucoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.