Clinical trials
Scleroderma clinical trials
Below are recruiting scleroderma clinical trials, each written for real people, not researchers. We’re tracking 43 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07292961Recruiting
Exercise program for people with scleroderma
This study tests if a special exercise program based on your body and mind can help people with scleroderma feel better. It is for both children (ages 7-18) and adults.
Ankara, AltındağAges 7 years+ - NCT07183072Recruiting
Scleroderma: Physical Performance and Functionality Study
This study looks at how scleroderma affects physical performance and daily function in children and adults. It aims to understand the impact of the disease on movement and everyday activities.
Çankaya, AnkaraAges 7 years+ - NCT07182981Recruiting
Chewing and swallowing in scleroderma patients
This study looks at how scleroderma affects chewing and swallowing in children and adults. It aims to help understand these problems better so care can be improved.
Çankaya, AnkaraAges 7 years+ - NCT01808937Recruiting
Study registry for morphea and storing DNA samples
This study is building a registry (a group record) of people with morphea and collecting DNA samples to help researchers learn more about the condition. It may help by improving understanding of causes, patterns, and future treatments.
Dallas, TexasAges Up to 90 years - NCT07090226Recruiting
Skin imaging study for diffuse scleroderma patients
This study uses a special camera (SFDI) to take painless images of your skin to see how scleroderma affects it. You may also be asked for a small skin sample (biopsy) to help understand the condition better.
Boston, MassachusettsAges 18 years+ - NCT06847750Enrolling by invitation
Ultrasound in Children with Localized Scleroderma (Morphea)
This study uses a special ultrasound (elastography) to measure how stiff or thick your skin patches are over time. It helps doctors understand morphea better and see if treatment is working, with no extra needles or radiation.
Toronto, OntarioAges Up to 18 years - NCT06195072RecruitingPhase 2
Platform study for scleroderma with lung disease
This trial tests new treatments for people with scleroderma-related lung disease. You may be eligible if you have systemic sclerosis with lung scarring, your symptoms started within the last 7 years, and you have not had certain prior treatments or transplants.
Birmingham, AlabamaAges 18 years+ - NCT07641634RecruitingPhase 1/Phase 2
Testing PRO-203 for active systemic sclerosis
This trial tests a new investigational medicine called PRO-203 for people with systemic sclerosis (scleroderma). It aims to see if the medicine can help control active disease that hasn't responded to other treatments.
Melbourne, VictoriaAges 18–65 - NCT07343115Recruiting
Studying familial systemic scleroderma
This study looks at families where two first-degree relatives have systemic scleroderma, a rare autoimmune disease that affects the skin and organs. It aims to understand genetic and environmental factors by examining patients and their family members.
StrasbourgAges 18 years+ - NCT07256418Recruiting
Skin cell study for scleroderma
This trial collects skin samples from people with scleroderma and from healthy volunteers undergoing plastic surgery. Researchers will study the genes in skin cells to better understand the disease.
DijonAges 18 years+ - NCT07182968Recruiting
Turkish questionnaire for scleroderma patients
This study is adapting a questionnaire to measure how scleroderma affects your daily life. Your responses will help make the tool more useful for Turkish-speaking patients.
Çankaya, AnkaraAges 18 years+ - NCT01656447Recruiting
Scleroderma patient registry and tissue repository study
This study builds a registry of people with scleroderma and may store medical information and samples for future research. It can help researchers better understand the disease and develop better treatments.
New York, New YorkAges 18 years+ - NCT04875078Enrolling by invitation
UVA-1 light treatment for hand skin tightness in scleroderma
This study tests whether UVA-1 light sessions can loosen tight skin and improve hand function in people with scleroderma. If you qualify, you would attend UVA-1 treatments twice a week for the study period.
Murray, UtahAges 18 years+ - NCT04797286RecruitingPhase 2
Sildenafil for early lung blood-pressure problems in scleroderma
This trial tests whether sildenafil can improve early “high pressure in the lung blood vessels” in people with scleroderma. It may help slow worsening breathing and lung blood-vessel disease before it becomes severe.
New Orleans, LouisianaAges 18 years+ - NCT04804930Recruiting
Skin and scalp exam study in systemic scleroderma
This study uses a detailed look at your skin and scalp (often with a magnifying exam) to learn more about systemic scleroderma. It may help doctors understand the condition better and improve how it’s assessed over time.
LilleAges 18 years+ - NCT07493395RecruitingPhase 2
CAR T-cell therapy for severe systemic sclerosis
This trial tests whether a special type of immune cell therapy, called CAR T-cells, can help people with severe systemic sclerosis (a disease causing skin and organ hardening) that hasn't improved with standard treatments. The goal is to see if it can stop the disease from getting worse.
LilleAges 18–64 - NCT06593041Recruiting
Platelets in lupus and other autoimmune diseases
This study looks at how platelets (small blood cells that help with clotting) might play a role in autoimmune diseases like lupus. By understanding this, researchers hope to find new ways to treat these conditions.
Strasbourg, FranceAges 18–70 - NCT06339957Recruiting
Rheumatology diet study for arthritis and related conditions
This study looks at how diet affects people with different types of arthritis and related autoimmune conditions. If you are a UCF Health patient between 18 and 65, you may be able to help researchers learn more about which foods help or worsen symptoms.
Orlando, FloridaAges 18–65 - NCT07491523Recruiting
Adding anti-fibrotic to immunosuppression for scleroderma lung disease
This trial is testing whether adding an anti-fibrotic drug (a medicine that fights scarring) to two immunosuppressive drugs works better than the two drugs alone for people with scleroderma-related lung disease.
PátraiAges 18 years+ - NCT07470151Recruiting
Study of EVM18001 for hard-to-treat autoimmune diseases
This trial tests a new treatment, EVM18001, for people with lupus, myasthenia gravis, or systemic sclerosis that hasn't improved with standard therapies. It aims to see if this therapy can help control the disease.
Wuhan, HubeiAges 18–70 - NCT07345052Recruiting
Study on systemic sclerosis in western Sweden
This study is looking at people with systemic sclerosis (a condition that causes hardening and tightening of the skin and can affect internal organs) to learn more about the disease. You may join if you have been diagnosed with this condition and meet a few other requirements.
Gothenburg, SwedenAges 18 years+ - NCT07251179Recruiting
Understanding immune cells in autoimmune diseases and immune deficiencies
This study looks at immune cells in people with certain autoimmune diseases or immune deficiencies. The goal is to understand how these cells work, which may help improve future treatments.
StrasbourgAges 18–70 - NCT07245238RecruitingPhase 3
CBD lotion for itching in scleroderma
This trial tests if a CBD (cannabidiol) lotion can help reduce itching in people with scleroderma, a condition that often causes chronic itch. It compares the CBD lotion to a placebo (inactive lotion) to see if it works and is safe.
Khon KaenAges 18–70 - NCT01793168Recruiting
Rare disease registry and history study
This study keeps a registry (a structured list) of people with rare diseases and may also track how the condition changes over time. It can help researchers better understand rare illnesses and find gaps in care, which may improve future treatments.
Sioux Falls, South DakotaAges Any age
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Scleroderma trials by city
Studies with a site in or near these metro areas.
Scleroderma trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for scleroderma?
- Yes. Clin2 currently lists 43 recruiting scleroderma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a scleroderma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a scleroderma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.