Cell injections for mouth stiffness in scleroderma
Treatments studied
Part of Genetic & congenital, Mouth & dental, Skin clinical trials.
This study tests whether injecting special cells (called mesenchymal stromal cells) from a healthy donor into the mouth area can reduce scarring (fibrosis) and improve mouth function in people with systemic scleroderma. It may help make it easier to open your mouth and reduce daily discomfort.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have been diagnosed with systemic scleroderma by a doctor.
- Your mouth opening is less than 40 millimeters (about 1.6 inches) between your upper and lower teeth.
- You have significant mouth-related disability, with a score of 20 or higher on a standard questionnaire.
- You have not had a stem cell transplant in the past year and have not had cancer in the last 5 years (except certain cured skin cancers).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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