Clinical trials
Somatic Symptom Disorder clinical trials
Below are recruiting somatic symptom disorder clinical trials, each written for real people, not researchers. We’re tracking 22 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05792930Recruiting
Therapy plus biofeedback for body-symptom distress
This study tests an integrated talk-therapy program that combines cognitive-behavioral therapy and biofeedback to help people whose symptoms are strongly felt in the body. It may help by teaching skills to reduce distress and improve how you manage symptoms.
YunlinAges 20–70 - NCT05161819Recruiting
Repetitive brain magnetic treatment for somatic symptom disorder
This trial tests whether repetitive transcranial magnetic stimulation (a non-surgical treatment that uses magnets on the scalp) can help people with somatic symptom disorder. If you qualify, you would be evaluated for symptom improvement and for safety during the treatment period.
Douliu, YunlinAges 20–70 - NCT07323407Recruiting
Brain stimulation for hard-to-treat constipation with bodily distress
This trial tests if a gentle electrical current applied to the scalp can improve severe constipation in people who also experience persistent physical symptoms (like pain or bloating) that cause high worry. It is for those who have not gotten relief from standard laxatives.
Xi'an, ShaanxiAges 18–80 - NCT06803485RecruitingPhase 4
Comparing two antidepressants for pain-related somatic symptom disorder
This trial tests whether venlafaxine or dosulepin works better for people whose main problem is pain from a condition called somatic symptom disorder. You may join if you are 18–65, have not recently taken similar medication, and do not have other serious health issues.
Bhubaneswar, OdishaAges 18–65 - NCT07646509Recruiting
Mobile app to reduce physical symptoms from stress
This study tests a smartphone app designed to help people with somatic symptom disorder—a condition where stress and emotional distress cause ongoing physical symptoms that don't have a clear medical explanation. The app sends you check-ins and guidance throughout your day to help reduce these symptoms.
Vienna, State of ViennaAges 18–65 - NCT04899687RecruitingPhase 2
Dextromethorphan for OCD and related anxiety conditions
This trial studies dextromethorphan, a medicine sometimes used for cough, to see if it can reduce symptoms in OCD and similar conditions. It may help people whose intrusive thoughts or related worries are still challenging despite current care.
Stanford, CaliforniaAges 18–65 - NCT05666921Recruiting
Study thoughts and relationships in teens with body-pain symptoms
This trial studies how emotions and attachment (how people relate to others) may affect teens who have long-lasting body symptoms without an organic cause. It may help explain why symptoms happen and how support strategies could improve quality of life.
Florence, FirenzeAges 11–17 - NCT06582173Recruiting
Mapping healthcare paths for teens with physical symptoms linked to stress
This study maps how 12–25 year olds with somatic symptom disorder (physical symptoms caused by stress or emotions) get diagnosed and treated. It aims to improve care by understanding the best ways to evaluate and support these young people and their families.
Paris, IDFAges 12 years+ - NCT06975280Recruiting
PTSD therapy for unaccompanied refugee teens in Greece
This study tests a talking therapy (Trauma-Focused Cognitive Behavioral Therapy) to help unaccompanied refugee minors aged 15-18 who have PTSD or stress symptoms from trauma. It aims to see if the therapy reduces distress and helps them feel better.
AthensAges 15–18 - NCT07476469Recruiting
Nerve stimulation for anhedonia and anxiety
This study tests whether a gentle nerve stimulation device (tVNS) placed on your ear can help reduce symptoms of anhedonia (loss of pleasure) and anxiety. You will also have brain scans (MRI) to see how the treatment affects your brain.
BonnAges 18–40 - NCT05946512Recruiting
Yoga breathing plus lung MRI measurements for post-COVID symptoms
This study uses breathing exercises from yoga and MRI (a scan of the body) measurements to see how well yoga breathing can improve ongoing breathing symptoms after COVID-19. It also compares results in a few other specific groups and healthy volunteers.
Innsbruck, TyrolAges 18–50 - NCT07198542Enrolling by invitation
Vagus nerve stimulation for somatic symptom disorder
This trial tests if gentle electrical stimulation on the vagus nerve in the ear or neck can help reduce physical symptoms that are closely linked to stress. It is for adults with somatic symptom disorder who are on stable medications.
Douliu, YunlinAges 18–65 - NCT07682064Recruiting
Group therapy for emotional disorders in adults
This trial tests a group therapy program for adults with emotional disorders like depression or anxiety. It is designed to help you manage difficult emotions and improve your well-being.
Logroño, La RiojaAges 18–65 - NCT05525598Recruiting
Online therapy for severe body–mind symptom disorders
This trial tests an internet-based treatment program for people with moderate-to-severe functional somatic disorders (long-lasting physical symptoms linked to how the body and brain interact). It may help reduce symptoms and improve day-to-day functioning by offering structured support online.
Aarhus C, DenmarkAges 18–60 - NCT06232473RecruitingPhase 4
Education and duloxetine for multisystem functional somatic disorder
This trial tests whether a combination of patient education and the medication duloxetine can help people with a condition that causes multiple unexplained physical symptoms (functional somatic disorder). It aims to see if using both treatments together works better than either alone.
AarhusAges 18–60 - NCT06221722Recruiting
Brain scan study for treating constipation
This trial uses brain scans to see if doctors can predict how well constipation treatments will work. It is for adults with functional constipation, but only if they have no other digestive problems or medical implants.
Yinchuan, NingxiaAges 18–45 - NCT07067619Recruiting
Pain acceptance training for emotional and physical distress
This trial tests a training program to help people accept chronic pain and emotional distress. It looks at how thinking patterns might help or hinder progress.
HaifaAges 18–70 - NCT07543328Recruiting
Light therapy added to antidepressants for depression with body symptoms
This study tests whether a special light treatment applied to the scalp (transcranial photobiomodulation) can help people with depression who aren't getting better with antidepressants alone. The light therapy is added to your current medication to see if it reduces both mood symptoms and physical complaints like pain or fatigue.
TaipeiAges 18–65 - NCT06994988Recruiting
Smart band-aid study for chronic pain in women
This trial tests a special band-aid that measures chronic pain. Women with chronic pain or healthy women may join to help researchers learn how this device works.
Chicago, IllinoisAges 18 years+ - NCT05832489RecruitingPhase 3
EEG-MRI test of methylphenidate in adult attention symptoms
This Phase 3 study tests how methylphenidate affects brain signals and attention in adults with ADHD, and in adults with mood-related attention problems. It also includes healthy volunteers to compare brain responses during brain scanning.
StrasbourgAges 18–60 - NCT05635812Recruiting
Brain and eye tests of facial emotion recognition in autism
This study uses brain and eye measurements to understand how people recognize facial expressions, including in autism and related conditions. It may help researchers find markers that better explain autism-related symptoms and differences in processing emotions.
DijonAges 7–50 - NCT06919133Enrolling by invitation
Using smartphone markers to manage depression symptoms
This study tests whether using a smartphone app to track your mood and behavior can help you manage depression symptoms better. You'll use digital tools to monitor your own progress and learn self-management strategies.
FrederiksbergAges 18 years+
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Common questions
- Are there clinical trials for somatic symptom disorder?
- Yes. Clin2 currently lists 22 recruiting somatic symptom disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a somatic symptom disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a somatic symptom disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.