Clinical trials
Substance Use Disorders clinical trials
Below are recruiting substance use disorders clinical trials, each written for real people, not researchers. We’re tracking 409 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07490717Enrolling by invitation
Treating PTSD and opioid use in jails
This study tests new ways to screen and treat people in jail who have both post-traumatic stress disorder (PTSD) and opioid use disorder. It aims to help participants with therapy while incarcerated and after release.
Little Rock, ArkansasAges 18 years+ - NCT07487155Recruiting
Coordinating care for ADHD and addiction in prison
This trial tests a new way of coordinating care for people in prison who have both ADHD and a substance use disorder. It combines medical treatment, addiction services, and team-based support all in one program.
BrestAges 18 years+ - NCT07443033Recruiting
Psychosocial factors in dual diagnosis for hospital patients
This study looks at the emotional and social factors that affect people with a dual diagnosis, which means having both a mental health condition and a substance use problem. By understanding these factors, doctors hope to improve care for patients during their hospital stay.
Plasencia, CaceresAges 18 years+ - NCT07439783Enrolling by invitation
Testing a training program to improve staff retention in child welfare
This trial tests a new training model designed to help keep child welfare supervisors and their teams (including case workers and peer supporters) happy and on the job, so they can better help families. It focuses on agencies that are part of Ohio START.
Columbus, OhioAges 18 years+ - NCT07364240Recruiting
Occupational therapy for substance use recovery
This study tests whether occupational therapy (daily-life skill building) tailored to you can help in recovery from substance use disorder. You may benefit if you've completed detox and are ready to rebuild routines.
IstanbulAges 18–65 - NCT07364799Recruiting
Sound therapy for stress in detained teens
This trial tests a multi-sensory therapy called SoundHeal for teens in juvenile detention. It uses sound and vibration to help with stress, anxiety, depression, or substance use.
San Luis Obispo, CaliforniaAges 12–18 - NCT07342504Recruiting
Brief alcohol support for people on buprenorphine
This trial tests a brief alcohol-focused support program designed for people who are already taking buprenorphine for opioid addiction. The goal is to help you reduce your drinking in a way that fits with your current treatment.
Notre Dame, IndianaAges 18 years+ - NCT07342218Recruiting
Digital substance use treatment for federal parolees
This trial tests digital tools for people with substance use problems who are living in halfway houses or community correctional centres after serving a federal prison sentence. The tools are designed to help with recovery and re-entry.
Brantford, OntarioAges 18–55 - NCT07340554Recruiting
Brain imaging study for teens who use cannabis
This study looks at the brains of teenagers who use cannabis using an MRI scanner. It aims to understand how cannabis affects the developing brain, which might help improve treatment options.
Indianapolis, IndianaAges 14–17 - NCT06856148Recruiting
Improving substance misuse prevention research use in state policy
This study aims to better share research on preventing substance misuse with state policymakers. It is for state-level public officials who help make or influence policy.
University Park, PennsylvaniaAges Any age - NCT06870110Recruiting
Brain training for opioid use disorder
This trial tests a brain-training program for people with opioid use disorder. It uses an EEG headset to measure brain activity while you do computer exercises, and aims to see if this training can help recovery.
Minneapolis, MinnesotaAges 18–65 - NCT07318480Recruiting
Brain stimulation for drug addiction
This study tests a type of brain stimulation (called tDCS) to help people reduce their use of stimulants (like crack/cocaine) or opioids. It might help lessen cravings and improve treatment outcomes.
New York, New YorkAges 18–60 - NCT07281261Recruiting
Nerve stimulation for alcohol use disorder
This study tests whether a mild nerve stimulation device (tAN) can help reduce alcohol cravings and withdrawal. It's for people with moderate to severe alcohol use disorder who are going through withdrawal and do not use tobacco.
Houston, TexasAges 18–64 - NCT07278427Recruiting
Reducing substance use in rural parents
This trial tests a program to help parents in rural Ohio reduce substance use and strengthen their families. You may be eligible if you are 18 or older and have had certain substance use issues.
Columbus, OhioAges 18 years+ - NCT07262372Recruiting
Supervision in substance use treatment programs
This trial studies how supervision works in substance use treatment programs. It looks at the roles of supervisors and counselors to help improve treatment for people with substance use disorders.
Little Rock, ArkansasAges 18 years+ - NCT07232641Recruiting
How pandemic rules affected opioid addiction treatment in the VA
This study looks at how changes in federal and state rules about medications for opioid use disorder during the pandemic affected veterans. It uses information already in your VA records, so there are no extra visits or tests needed.
Boston, MassachusettsAges 18 years+ - NCT07221396Enrolling by invitation
A text-based program to help reduce stimulant use
This study tests a text-message program called LDART to help people who use cocaine or other stimulants cut down or quit. If you live in Connecticut, have a smartphone, and want to reduce your stimulant use, you may be able to join.
New Haven, ConnecticutAges 18 years+ - NCT07219394Recruiting
Peer support for depression in community care
This trial tests if peer-delivered behavioral therapy can help adults with depression symptoms. If you are 18 or older and feel sad or down, this study may teach you practical ways to feel better.
Detroit, MichiganAges 18 years+ - NCT07214467Recruiting
Adaptive brain stimulation for opioid use disorder
This study tests a new type of brain stimulation that adapts to your brain activity, aiming to reduce cravings and help you control opioid use. It is for people with long-standing opioid use disorder who have not gotten lasting relief from at least 3 treatment attempts, including medication.
San Francisco, CaliforniaAges 22–75 - NCT07218549RecruitingPhase 1
Study of psychoactive substances in people with past opioid use
This trial tests how safe certain psychoactive substances are and what effects they have in people who have used opioids in the past but are not currently dependent on them. It aims to gather information that could help future treatment options.
Houston, TexasAges 18–55 - NCT07215221Recruiting
TBI screening in substance use treatment
This study tests a new way to screen for traumatic brain injury (TBI) among people receiving substance use treatment. If you are in outpatient therapy for substance use, you may be able to join.
Columbus, OhioAges 18 years+ - NCT06922721Recruiting
Addiction, trauma, and immigration study for young adults
This study looks at how addiction, trauma, and immigration affect young adults living in housing centers. It aims to better understand their needs and how to help them.
Jarville-la-MalgrangeAges 18–25 - NCT07211867Recruiting
Reducing self-stigma in pregnant women and new mothers with substance use
This trial tests a digital tool called Enhearten that aims to decrease self-stigma (negative feelings about yourself) in pregnant women and new mothers who have used substances (other than alcohol or tobacco). The study hopes to help participants feel better about themselves and seek support.
St Louis, MissouriAges 18 years+ - NCT07210268Recruiting
Brain stimulation for nicotine addiction treatment
This trial tests a new method called temporal interference to stimulate the brain and help people who vape nicotine reduce their addiction. It aims to see if this non-invasive approach can make it easier to quit.
Bloomington, IndianaAges 21–50
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Common questions
- Are there clinical trials for substance use disorders?
- Yes. Clin2 currently lists 409 recruiting substance use disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a substance use disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a substance use disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.