Clinical trials
Substance Use clinical trials
Below are recruiting substance use clinical trials, each written for real people, not researchers. We’re tracking 221 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05486234Recruiting
Study to reduce cannabis and alcohol use with teen and caregiver
This study looks at ways to help teens cut down on cannabis and alcohol use. You may qualify if you’ve been using both in the last three months and your caregiver is able to join and consent.
Charleston, South CarolinaAges 13–17 - NCT06823453Recruiting
Training friends and family to support people who use opioids
This study trains friends and family members of people who use opioids, so they can provide better support and reduce stigma. It also includes people who use opioids to see if this training improves their relationship and well-being.
Chicago, IllinoisAges 18 years+ - NCT07527871Enrolling by invitation
Emergency care screening and counseling for substance use prevention
This study tests whether screening patients in the emergency department for substance use, followed by a brief counseling session, can help prevent substance use problems and overdoses. You would be asked about your substance use and receive supportive counseling by phone or video.
Columbus, OhioAges 18 years+ - NCT05854836Recruiting
Pre-pregnancy support for incarcerated women with substance use
This study tests a preconception (before pregnancy) support program for incarcerated women who have used substances and could become pregnant. It may help improve health and planning before a future pregnancy.
St Louis, MissouriAges 18–49 - NCT06880705Recruiting
Trans-Led Care Study for alcohol and drug support
This study is testing a program designed by and for transgender adults to help with alcohol or drug use problems. It looks at whether a supportive, community-based approach can improve health and well-being.
Chicago, IllinoisAges 18 years+ - NCT04197921Recruiting
Brain-focused ultrasound for opioid addiction-related substance use
This trial studies Exablate, a non-surgical brain treatment that aims to change activity in a specific brain area involved in cravings and substance use. It is meant for people in structured opioid or substance use treatment who are currently abstaining from opioids and other illicit drugs.
Tampa, FloridaAges 18–60 - NCT06158607Recruiting
PrEP adherence help for women with substance use
This study tests a program to help Black and Hispanic women with substance use disorders take PrEP consistently to prevent HIV. The goal is to see if talking with a health coach can improve PrEP use and reduce HIV risk.
Houston, TexasAges 18–60 - NCT06442423RecruitingPhase 1
Psilocybin study for people with psychiatric symptoms
This trial tests if psilocybin, a substance found in certain mushrooms, can help people with various mental health symptoms that affect daily life. You would take a single dose in a supervised setting and be monitored for changes in your mood and well-being.
New Haven, ConnecticutAges 18 years+ - NCT06608979Recruiting
Trauma screening and violence prevention for women in addiction treatment
This study offers trauma screening and a program to help prevent interpersonal violence for women who are currently receiving treatment for substance use. It aims to understand how these services can improve safety and well-being.
Greenville, South CarolinaAges 18 years+ - NCT06677515Recruiting
Using VR to improve social skills in people with substance use and mental health issues
This study tests whether virtual reality (VR) training can help people with substance use and mental health disorders improve their social functioning. If you are getting treatment for substance use and can attend VR sessions twice a week for 5 weeks, you may be able to join.
BrumunddalAges 18–70 - NCT06701487Recruiting
Brain learning mechanisms and substance use control
This study looks at how certain learning mechanisms in the brain (called Pavlovian conditioning) influence your ability to control alcohol or drug use. It may help explain why some people have trouble stopping, and could lead to better treatments. You'll fill out questionnaires and likely have a brain scan (MRI).
DresdenAges 18–65 - NCT06856148Recruiting
Improving substance misuse prevention research use in state policy
This study aims to better share research on preventing substance misuse with state policymakers. It is for state-level public officials who help make or influence policy.
University Park, PennsylvaniaAges Any age - NCT06959342Recruiting
Brain stimulation to reduce cravings in alcohol use disorder
This trial tests if a gentle brain stimulation technique (tDCS) can help people with alcohol use disorder control their cravings and drinking habits. It is an add-on to your regular treatment.
MannheimAges 18–65 - NCT07071779Recruiting
Online training to help young people resist alcohol or cocaine
This study tests a web-based training program to help teens and young adults (ages 14–35) improve their ability to say no to alcohol or cocaine. The training could make it easier to resist cravings during treatment.
BernAges 14–35 - NCT07281261Recruiting
Nerve stimulation for alcohol use disorder
This study tests whether a mild nerve stimulation device (tAN) can help reduce alcohol cravings and withdrawal. It's for people with moderate to severe alcohol use disorder who are going through withdrawal and do not use tobacco.
Houston, TexasAges 18–64 - NCT07340554Recruiting
Brain imaging study for teens who use cannabis
This study looks at the brains of teenagers who use cannabis using an MRI scanner. It aims to understand how cannabis affects the developing brain, which might help improve treatment options.
Indianapolis, IndianaAges 14–17 - NCT04294134Enrolling by invitation
Support program for mothers in residential substance treatment
This trial tests a support program for mothers (pregnant or with young children) who are in residential substance use treatment. It aims to improve well-being, family stability, and child safety—especially when children are at risk or in out-of-home placement.
Philadelphia, PennsylvaniaAges Any age - NCT07575373Recruiting
Improving Hospital Care for People With Substance Use Disorders
This study tests a new team-based approach to help hospitalized patients with substance use disorders get better care and smoother transitions when leaving the hospital. Researchers want to see if coordinated support from doctors, counselors, and social workers can improve your health outcomes and connection to treatment.
Salt Lake City, UtahAges 18 years+ - NCT06470698Recruiting
Using emotional awareness to predict treatment success in addiction
This trial tests whether tracking emotional awareness can help predict how well people recover from cocaine or alcohol addiction. It uses a mobile app to monitor feelings and progress.
HuelvaAges 18 years+ - NCT06585631Recruiting
Collaborative care for young men with HIV and substance use
This study looks at how to better support young men living with or at risk for HIV while also addressing substance use. You'll work with a care team that helps you stay healthy and connected to services.
Baltimore, MarylandAges 15–29 - NCT07211867Recruiting
Reducing self-stigma in pregnant women and new mothers with substance use
This trial tests a digital tool called Enhearten that aims to decrease self-stigma (negative feelings about yourself) in pregnant women and new mothers who have used substances (other than alcohol or tobacco). The study hopes to help participants feel better about themselves and seek support.
St Louis, MissouriAges 18 years+ - NCT07364240Recruiting
Occupational therapy for substance use recovery
This study tests whether occupational therapy (daily-life skill building) tailored to you can help in recovery from substance use disorder. You may benefit if you've completed detox and are ready to rebuild routines.
IstanbulAges 18–65 - NCT07503067Recruiting
Understanding substance use consequences
This study looks at the experiences and consequences of substance use. It is for people who either use substances, care for someone who does, or have a close friend or family member who does.
Belmont, MassachusettsAges 18 years+ - NCT06743282Enrolling by invitation
Study on mobile support for substance use in primary care
This trial tests a program called Senyo Health that provides support through text messages and video calls for people with substance use concerns. It aims to help you manage your substance use while working with your primary care doctor.
Scottsdale, ArizonaAges 18 years+
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Substance Use trials by city
Studies with a site in or near these metro areas.
Substance Use trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for substance use?
- Yes. Clin2 currently lists 221 recruiting substance use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a substance use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a substance use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.