Clinical trials
Substance Use Disorders clinical trials
Below are recruiting substance use disorders clinical trials, each written for real people, not researchers. We’re tracking 409 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07197476Recruiting
Helping teens after a traumatic injury
This study tests a program to help teens who have been in the hospital for a traumatic injury. It aims to reduce stress and substance use by offering a supportive intervention.
Providence, Rhode IslandAges 12–17 - NCT07199335RecruitingPhase 4
Injectable HIV prevention drug for people who inject drugs
This study tests a long-acting injectable medication called cabotegravir to prevent HIV in people who inject drugs. If you have injected street drugs recently, you may be able to get this shot every few months instead of taking daily pills.
Boston, MassachusettsAges 18 years+ - NCT07146633Recruiting
Testing an EMDR app for PTSD and substance use
This study tests an app that uses EMDR therapy to help people with both PTSD and substance use problems. EMDR is a type of therapy that uses eye movements or taps to help process traumatic memories. You would use the app at home and avoid starting other new therapies during the study.
Toronto, OntarioAges 18 years+ - NCT07141394Enrolling by invitation
Supporting recovery for homeless veterans in VA housing
This trial helps homeless veterans in VA supportive housing get coordinated access to addiction recovery services. It aims to improve equity and outcomes for those in recovery.
West Los Angeles, CaliforniaAges Any age - NCT07130500Enrolling by invitation
Rewards for sticking with long-acting injections
This study tests whether offering small rewards (like gift cards) can help people stick with a long-acting injection of their medication. It's for people with serious mental health conditions who have had a recent hospital stay or are at high risk of one.
Pittsburgh, PennsylvaniaAges 18–65 - NCT06978452Recruiting
Youth mental health: tracking development and outcomes
This study looks at how young people's mental health develops over time. It compares youth who have already sought help for mental health concerns with those who haven't, to better understand what helps or hinders well-being.
Montreal, QuebecAges 9–25 - NCT07071779Recruiting
Online training to help young people resist alcohol or cocaine
This study tests a web-based training program to help teens and young adults (ages 14–35) improve their ability to say no to alcohol or cocaine. The training could make it easier to resist cravings during treatment.
BernAges 14–35 - NCT07056894Recruiting
Cognitive training for substance use in early psychosis
This study tests a computer-based cognitive training program to help people with early psychosis reduce their alcohol and cannabis use. The program is designed to improve thinking skills and may make it easier to cut back on substance use.
St. John's, Newfoundland and LabradorAges 16–30 - NCT07044531Recruiting
Peer recovery supporter training program study
This study tests a new training platform for peer recovery support specialists (PRSS). If you are in recovery and want to help others, this program could give you the skills you need.
Solon, OhioAges 18 years+ - NCT07042451Recruiting
Testing a phone app to support recovery after substance use treatment
This trial is testing whether a smartphone app called Pink Cloud can help people stay in recovery after finishing substance use treatment. You would need to attend one recovery meeting in the next week and use the app on your personal phone.
Los Angeles, CaliforniaAges 18 years+ - NCT06959342Recruiting
Brain stimulation to reduce cravings in alcohol use disorder
This trial tests if a gentle brain stimulation technique (tDCS) can help people with alcohol use disorder control their cravings and drinking habits. It is an add-on to your regular treatment.
MannheimAges 18–65 - NCT06981195RecruitingPhase 2
Testing lemborexant for insomnia in people on buprenorphine
This study tests if the sleep medication lemborexant can help people with opioid use disorder who also have chronic insomnia. Participants must already be taking buprenorphine (Suboxone) for at least 4 weeks. The goal is to see if better sleep improves mood and reduces opioid use.
Richmond, VirginiaAges 18 years+ - NCT06973512Recruiting
Brain stimulation for severe addiction
This trial tests a new brain stimulation approach for people with severe addiction that hasn't gotten better with other treatments. It uses deep brain stimulation guided by brain mapping to try to reduce cravings and help you stay abstinent.
Toronto, OntarioAges 25–65 - NCT06968832Recruiting
Prolonged therapy for PTSD and substance use
This trial tests a therapy that helps people with both post-traumatic stress disorder (PTSD) and a substance use disorder (SUD). You'll receive extended therapy sessions to reduce PTSD symptoms and support your recovery from substance use, while continuing your current substance use treatment.
Jacksonville, FloridaAges 18 years+ - NCT06939088RecruitingPhase 2
Tirzepatide for alcohol reduction in schizophrenia
This trial tests if tirzepatide, a once-weekly injection, can help reduce heavy drinking in people who have both schizophrenia and alcohol use disorder. If you struggle with alcohol and have stable schizophrenia, this study may offer a new treatment option.
Aalborg, DenmarkAges 18–70 - NCT06923423Recruiting
Cognitive processing therapy for drug use and trauma in prison
This study tests if a type of therapy called cognitive processing therapy (CPT) can help people in prison who have both a drug use problem and trauma-related stress. If you qualify, you would receive CPT and be compared to those getting usual care.
Little Rock, ArkansasAges 18 years+ - NCT06922617Recruiting
Comparing e-cigarettes to standard quitting aids for people in addiction treatment
This study compares two ways to help people who are in treatment for substance use also quit or reduce smoking: using e-cigarettes or using standard nicotine replacement therapy (like patches or gum). If you're ready to make a change in your smoking, this could be a helpful option.
Charleston, South CarolinaAges 21 years+ - NCT06858527Recruiting
Combined ADHD and substance use treatment study
This study tests a combined treatment for adults who have both ADHD and a substance use disorder. It looks at whether an integrated approach helps people better manage both conditions together.
ParisAges 18 years+ - NCT06880705Recruiting
Trans-Led Care Study for alcohol and drug support
This study is testing a program designed by and for transgender adults to help with alcohol or drug use problems. It looks at whether a supportive, community-based approach can improve health and well-being.
Chicago, IllinoisAges 18 years+ - NCT06883162RecruitingPhase 3
A study to help people stop smoking tobacco and reduce cannabis use
This study tests whether a medication called varenicline (or a placebo) can help people who use both tobacco and cannabis to quit or cut back. It takes place in South Carolina and lasts 12 weeks.
Charleston, South CarolinaAges 18 years+ - NCT06863909Enrolling by invitation
Journaling plus cognitive behavioral therapy for better results
This trial explores whether adding journaling to your regular cognitive behavioral therapy sessions helps you feel better more quickly. You keep seeing your therapist as usual, just add a few minutes of writing each day.
TübingenAges 18–65 - NCT06163651Recruiting
Parent-child support program for parents of young children
This trial tests a one-year program to help parents with young children. It offers support and resources to strengthen your family.
Enid, OklahomaAges 18 years+ - NCT06856161Recruiting
Blood test to help diagnose mental health conditions
This study is testing a new blood test that might help doctors better understand and diagnose conditions like depression, psychosis, or schizophrenia. If you are 19 or older and have one of these conditions, you may be able to join.
New Westminster, British ColumbiaAges 19 years+ - NCT06854757Recruiting
Support after losing a loved one to overdose
This study is for people who lost a loved one to an unintentional drug overdose in the past year. It looks at how families are doing after such a loss and what kind of support might help.
Birmingham, AlabamaAges 18 years+
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Common questions
- Are there clinical trials for substance use disorders?
- Yes. Clin2 currently lists 409 recruiting substance use disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a substance use disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a substance use disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.