Clinical trials
Substance Use clinical trials
Below are recruiting substance use clinical trials, each written for real people, not researchers. We’re tracking 221 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04927143Recruiting
Using phone incentives to support substance abstinence
This study tests a smartphone app that gives changing rewards to help people avoid drug use. It targets adults in substance treatment and tries to see if incentives can improve abstinence during treatment.
Oconomowoc, WisconsinAges 18 years+ - NCT05934305Recruiting
Help for shame and stigma in HIV and substance use
This study tests whether a program can reduce shame and stigma for people living with HIV who also have a substance use disorder. It may help you feel less judged and cope better, while supporting HIV care.
Miami, FloridaAges 18 years+ - NCT06320015Recruiting
Peer support for recovery after an emergency visit
This trial tests whether a peer recovery worker can help adults who came to the emergency room for a drug- or alcohol-related problem stay engaged in recovery. If you join, you'll get extra support from someone who has been through similar experiences.
Providence, Rhode IslandAges 18 years+ - NCT07684976Recruiting
Safety of a helmet device using ultrasound for substance use disorder
This study tests a special helmet that uses focused ultrasound to stimulate parts of the brain involved in addiction. It aims to see if the treatment is safe and works for people with moderate to severe substance use disorder who have not gotten enough help from standard medication treatments.
Toronto, OntarioAges 18–70 - NCT06922617Recruiting
E-cigarettes vs. Nicotine Replacement for Smoking in Substance Use Treatment
This study compares e-cigarettes to nicotine replacement therapy (like patches or gum) to help people who are in treatment for substance use disorder (like drugs or alcohol) quit or reduce smoking. It aims to find a safer way to cut back on cigarettes.
Charleston, South CarolinaAges 21 years+ - NCT06922721Recruiting
Addiction, trauma, and immigration study for young adults
This study looks at how addiction, trauma, and immigration affect young adults living in housing centers. It aims to better understand their needs and how to help them.
Jarville-la-MalgrangeAges 18–25 - NCT06973512Recruiting
Brain stimulation for severe addiction
This trial tests a new brain stimulation approach for people with severe addiction that hasn't gotten better with other treatments. It uses deep brain stimulation guided by brain mapping to try to reduce cravings and help you stay abstinent.
Toronto, OntarioAges 25–65 - NCT07042451Recruiting
Testing a phone app to support recovery after substance use treatment
This trial is testing whether a smartphone app called Pink Cloud can help people stay in recovery after finishing substance use treatment. You would need to attend one recovery meeting in the next week and use the app on your personal phone.
Los Angeles, CaliforniaAges 18 years+ - NCT07071766Recruiting
Support for new mothers on opioid treatment
This study tests ways to improve outcomes for mothers who are receiving medication for opioid use disorder, from late pregnancy through the first year after giving birth.
Little Rock, ArkansasAges 18 years+ - NCT07386574Recruiting
Digital training for health workers on substance use
This trial tests a digital training program for frontline health workers to help them better recognize and support people with substance use disorders. It aims to make it easier for patients to get the right care from providers they already see.
KarachiAges 18 years+ - NCT07278427Recruiting
Reducing substance use in rural parents
This trial tests a program to help parents in rural Ohio reduce substance use and strengthen their families. You may be eligible if you are 18 or older and have had certain substance use issues.
Columbus, OhioAges 18 years+ - NCT06221839Recruiting
Racism, Decision Making, and Substance Use in Teens
This study looks at how experiences of racism and stress affect decision-making and the risk of substance use in adolescents. It involves an interview and possibly an MRI brain scan.
New York, New YorkAges 11–14 - NCT06003725Recruiting
Drug treatment for Black youth on probation
This study is testing a drug treatment program that is made for Black youth involved with the justice system. It aims to see if a more culturally fitting approach can help reduce substance use and related problems.
San Francisco, CaliforniaAges 13–17 - NCT06489899Recruiting
Peer education for substance use and gender fairness in teens
This trial tests a program where young people learn from peers about reducing substance use and promoting gender equity. Participants will join workshop sessions and vocational training to build skills and healthier habits.
Cape Town, Western CapeAges 16–24 - NCT06977178Recruiting
Teen anxiety and substance use study
This study looks at how anxiety in young teens might lead to substance use later. It uses brain scans and stress tests to understand these pathways.
Chapel Hill, North CarolinaAges 12–14 - NCT07342218Recruiting
Digital substance use treatment for federal parolees
This trial tests digital tools for people with substance use problems who are living in halfway houses or community correctional centres after serving a federal prison sentence. The tools are designed to help with recovery and re-entry.
Brantford, OntarioAges 18–55 - NCT04885569Recruiting
Therapy program to help prevent relapse in substance use
This trial tests a culturally adapted therapy combining motivational interviewing, CBT (talk-based skills therapy), and mindfulness to help people avoid relapse after detox. It may help you build coping tools and stay engaged in treatment.
LahoreAges 18 years+ - NCT07215221Recruiting
TBI screening in substance use treatment
This study tests a new way to screen for traumatic brain injury (TBI) among people receiving substance use treatment. If you are in outpatient therapy for substance use, you may be able to join.
Columbus, OhioAges 18 years+ - NCT06790641Recruiting
Supporting mental health during and after pregnancy
This study aims to improve mental health care for people during and after pregnancy. It involves interviews or focus groups with healthcare providers, peer mentors, and patients to understand how to make support services more helpful and accessible.
Shrewsbury, MassachusettsAges 18–70 - NCT07509853Recruiting
Pleasure-Focused Harm Reduction for Chemsex and Substance Use
This study explores how adding conversation about sexual pleasure to harm reduction services can help men who have sex with men and transgender persons who use drugs during sex or use other substances. If you join, you may learn new ways to reduce risks while still enjoying your sex life.
Pathum Wan, BangkokAges 18 years+ - NCT07590115Enrolling by invitation
Behavioral Patterns and Treatment Success in Substance Use Recovery
This study looks at how behavioral patterns change during residential treatment for substance use disorder. Researchers will track your progress over several weeks to understand what helps people succeed in recovery.
Potrerillos, JaliscoAges 18–60 - NCT05897164Recruiting
Mobile Technology to Reduce Teen Substance Misuse
Baltimore, MarylandAges 13 years+ - NCT04812613Enrolling by invitation
Study of cannabis use and mental health support for Ottawa youth
This study looks at tobacco use alongside other addictions in young people in Ottawa who have unstable housing and mental health concerns, and who use cannabis or have used it before. It may offer support or new approaches aimed at reducing health risks related to tobacco and substance use.
Ottawa, OntarioAges 16 years+ - NCT06163651Recruiting
Parent-child support program for parents of young children
This trial tests a one-year program to help parents with young children. It offers support and resources to strengthen your family.
Enid, OklahomaAges 18 years+
Hear when a new Substance Use trial opens
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Common questions
- Are there clinical trials for substance use?
- Yes. Clin2 currently lists 221 recruiting substance use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a substance use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a substance use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.