Clinical trials
Substance Use clinical trials
Below are recruiting substance use clinical trials, each written for real people, not researchers. We’re tracking 218 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06651528Enrolling by invitation
Trauma support program for substance use and reentry
This study tests a program for people in correctional facilities who have experienced violence and are in substance use treatment. It helps you prepare for release by building a support system in the community.
Frankfort, KentuckyAges 18–99 - NCT07756723RecruitingPhase 2/Phase 3
Comparing PTSD treatments for veterans with substance use
This study compares two proven treatments for veterans who have both PTSD and substance use problems. It aims to find which treatment works best to help with trauma recovery.
Coatesville, PennsylvaniaAges 18 years+ - NCT06794983Recruiting
Support after jail for health and substance use
This study tests a program that helps people leaving jail connect with healthcare and community services. It is for adults with a history of substance use and a chronic health condition who qualify for Wisconsin Medicaid.
Madison, WisconsinAges 18 years+ - NCT06296186Recruiting
PTSD treatment for veterans in substance use recovery
This trial tests a condensed form of prolonged exposure therapy for PTSD in veterans who are also receiving treatment for a substance use disorder. The goal is to help you process trauma and reduce substance use together.
San Diego, CaliforniaAges 18 years+ - NCT05538910Recruiting
Brain imaging study on substance use and depression
This study uses brain scans to understand how substance use and mental illness, like depression, are linked. It may help develop better treatments by looking at brain activity in people with and without depression.
Baltimore, MarylandAges 18–60 - NCT04939012Recruiting
MyPath tool to help postpartum women plan next pregnancy
This study tests a patient-centered tool (MyPath) that supports reproductive planning for women with substance use disorder during late pregnancy and right after delivery. The goal is to improve how you get guidance about future pregnancy choices and care.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07214467Recruiting
Adaptive brain stimulation for opioid use disorder
This study tests a new type of brain stimulation that adapts to your brain activity, aiming to reduce cravings and help you control opioid use. It is for people with long-standing opioid use disorder who have not gotten lasting relief from at least 3 treatment attempts, including medication.
San Francisco, CaliforniaAges 22–75 - NCT06798324RecruitingPhase 4
Brain stimulation plus smoking cessation medication for quitting smoking
This trial tests whether combining brain stimulation (tDCS) with a smoking cessation medication (varenicline) helps people quit smoking. You would attend daily visits for two weeks.
Toronto, OntarioAges 18–85 - NCT04459000Recruiting
Pregnant substance-use support through a prenatal clinic program
This trial is for pregnant people who are dealing with substance use during pregnancy and can receive care at a specific prenatal clinic. It aims to help connect participants to treatment and support resources.
Oklahoma City, OklahomaAges Up to 55 years - NCT07563517Recruiting
Peer coaching for substance use support in jail
This study tests whether connecting people in jail with peer coaches—people with lived experience of substance abuse recovery—can help them stay engaged with care after release. You'd receive support calls and guidance from someone who understands recovery firsthand.
Atlanta, GeorgiaAges 18 years+ - NCT07487155Recruiting
Coordinating care for ADHD and addiction in prison
This trial tests a new way of coordinating care for people in prison who have both ADHD and a substance use disorder. It combines medical treatment, addiction services, and team-based support all in one program.
BrestAges 18 years+ - NCT07262372Recruiting
Supervision in substance use treatment programs
This trial studies how supervision works in substance use treatment programs. It looks at the roles of supervisors and counselors to help improve treatment for people with substance use disorders.
Little Rock, ArkansasAges 18 years+ - NCT07692984Recruiting
Alcohol and drug use in people with schizophrenia or bipolar disorder
This study looks at how alcohol and substance use affects people with schizophrenia or bipolar disorder. It aims to understand if having these conditions together changes treatment or outcomes.
Bolu, BoluAges 18–65 - NCT04811014RecruitingPhase 4
Helping young adults stop opioids after an emergency visit
This study offers an engagement program for young people who tested positive for opioids and meet criteria for opioid dependence. The goal is to help participants stop opioid use safely and learn whether this approach works well in the real-world emergency setting.
Houston, TexasAges 13–17 - NCT04998916Recruiting
Brain stimulation to reduce heavy drinking in alcohol use disorder
This trial tests a type of noninvasive brain stimulation to see if it can reduce drinking and related “wanting” to drink. It may help people with alcohol use disorder who are currently drinking heavily.
Charleston, South CarolinaAges 21–65 - NCT06593652Recruiting
How caregivers can help teens with alcohol use
This study looks at how involving caregivers in a brief talk with a primary care provider might help teens who are drinking alcohol or using other substances. It aims to find better ways to support teens and their families.
Indianapolis, IndianaAges 12–17 - NCT07232641Recruiting
How pandemic rules affected opioid addiction treatment in the VA
This study looks at how changes in federal and state rules about medications for opioid use disorder during the pandemic affected veterans. It uses information already in your VA records, so there are no extra visits or tests needed.
Boston, MassachusettsAges 18 years+ - NCT07529327Recruiting
Language support groups for children of caregivers with substance use
This study offers weekly group sessions to help parents or caregivers support their young child's language development. It is designed for caregivers who have sought treatment for substance use or used substances in the past year, and whose child is between 12 and 42 months old and has a language delay.
Eugene, OregonAges 18 years+ - NCT07141394Enrolling by invitation
Supporting recovery for homeless veterans in VA housing
This trial helps homeless veterans in VA supportive housing get coordinated access to addiction recovery services. It aims to improve equity and outcomes for those in recovery.
West Los Angeles, CaliforniaAges Any age - NCT06952491Enrolling by invitation
Substance use support program
This study tests an online program that offers personalized education and support to help people who use substances improve their well-being and feel more confident in managing their health.
San Mateo, CaliforniaAges 21 years+ - NCT06501781Recruiting
PUSH: Helping People with HIV and Substance Use
This study tests if a program that encourages positive activities (behavioral activation) can help people with HIV or on PrEP who also use substances improve their health. It focuses on those receiving long-acting injectable medications for HIV prevention or treatment.
Washington D.C., District of ColumbiaAges 18–88 - NCT07516301Recruiting
Substance use screening for adult childhood cancer survivors
This study tests whether adding a quick substance use survey and a short follow-up conversation into your regular clinic visits is helpful. It is designed for people who were treated for childhood cancer and are now adults.
Memphis, TennesseeAges 15 years+ - NCT06929520Recruiting
ENDS intervention for rural Hawaiian youth
This trial tests a culturally tailored program to reduce e-cigarette (ENDS) use among rural middle school students in Hawaii. It may help if you are a 6th to 8th grader on Hawaii Island.
Honolulu, HawaiiAges 10–14 - NCT06701500Recruiting
Study on decision making in alcohol use disorder
This study looks at how people with alcohol use disorder make decisions based on habits, goals, and automatic cues. It may help understand what drives drinking behavior.
DresdenAges 18–65
Hear when a new Substance Use trial opens
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Common questions
- Are there clinical trials for substance use?
- Yes. Clin2 currently lists 218 recruiting substance use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a substance use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a substance use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.