Surgical clinical trials

Three-year results of combined microstent and canaloplasty surgery

This trial is checking how well a combined eye surgery (Hydrus microstent plus canaloplasty plus cataract surgery) works over 3 years. It looks at long-term safety and effect on eye pressure. It's for people with open-angle glaucoma who already had that specific combination of procedures.

Heart surgery for apical hypertrophic cardiomyopathy without valve pressure

This study looks at people who have had surgery to reshape the left side of the heart for a specific type of thickened heart muscle (apical hypertrophic cardiomyopathy). It helps doctors understand how well this surgery works in patients without a large pressure difference across the heart valve.

10-year knee implant follow-up study

This study follows patients who already took part in a previous trial for a knee implant (MP01). It checks how well the implant is working over 10 years compared to standard knee surgery.

Perioperative dexmedetomidine for chronic pain after lung surgery

This study tests whether giving the medication dexmedetomidine during and after surgery can prevent long-term pain after a thoracoscopic lung resection. If you are scheduled for this type of lung surgery, you may be able to join and help see if this drug makes recovery less painful over time.

Blood sugar monitoring during surgery to prevent infections

This trial checks if monitoring and treating blood sugar levels during long surgeries can lower the risk of infections and other problems afterward. It is for adults having any surgery expected to last 2 hours or more.

Cleaning methods for infected dental implants

This study is testing different ways to clean a dental implant that is failing due to severe infection (peri-implantitis). If you need to have an implant removed because of advanced bone loss, the researchers will compare cleaning methods during the removal procedure.

Early healing after periodontal surgery

This trial looks at how well gum surgery incisions heal in the first days and weeks after the procedure. It may help people with gum disease who need surgery to control their condition.

Different ways to prepare gum tissue during periodontal surgery

This study compares different surgical techniques for removing and preparing gum (gingival) tissue to support healing after periodontal procedures. It may help improve how these common mouth surgeries are done and what tissue ends up for analysis.

Endoscopic and bariatric procedures for obesity

This study looks at people who are having obesity-related procedures, including options done with a scope (endoscopic) and revision after prior bariatric surgery. It may help doctors understand outcomes and improve care for people undergoing these treatments.

Study of surgical trainees’ and staff’s non-technical skills

This study looks at “non-technical” skills (things like communication, decision-making, and teamwork) and how they relate to surgical experience. It may help training hospitals improve how they select and support people learning or working in surgery.

Mechanical Ventilation in Obese Surgical Patients

Radiation before surgery for recurrent adrenal cancer

This trial tests whether giving radiation before surgery helps people with adrenal cancer that has come back after previous treatment. It aims to see if this approach can improve outcomes for patients who can have surgery at the NIH.

Study recovery after bladder removal surgery

This trial looks at how patients recover after radical cystectomy, a surgery that removes the bladder for bladder cancer. It will study recovery patterns to help understand what recovery may look like and possibly improve care.

Bone regeneration surgery for lower molar gum disease

This study looks at the shape of lower molar teeth with a certain type of gum disease and tests a surgical treatment to help regrow the bone around those teeth. If you have advanced gum disease and a lower molar with a specific type of bone loss, this treatment might help save the tooth.

Hyaluronic acid to help gum disease treatment in smokers

This study tests whether adding hyaluronic acid (a natural substance) to standard gum disease treatment helps smokers recover better. Gum disease is serious in smokers, and this treatment might improve healing.

Mesh infection risk after abdominal wall repair

This study looks at why some people get an infection in the mesh used to fix a hole or weakness in the belly wall. The goal is to find risk factors so doctors can better prevent infections in the future.

Eye stiffness and healing in cataract surgery with PEX

This study looks at how your eye's outer layer (cornea) heals and changes shape after cataract surgery, specifically comparing people who have pseudoexfoliation syndrome (PEX) with those who do not. The goal is to see if PEX affects the final vision result after cataract removal.

Using hernia sac flap to cover mesh in bony-edged hernia repair

This trial tests whether using a flap of your own hernia sac to cover the mesh during hernia repair can improve healing. It's for people with a complex hernia that touches a bone, like near the breastbone or pelvis.

Testing adding cemiplimab to chemo before surgery for sinus cancer

This trial tests whether adding the immunotherapy drug cemiplimab to standard chemotherapy before surgery helps treat sinonasal squamous cell carcinoma. The goal is to see if this combination reduces tumors more effectively than chemotherapy alone.

Surgical correction for gummy smile

This study tests a surgical procedure to correct a gummy smile caused by a specific gum condition. It aims to see if the gum tissue stays stable after surgery.

Testing a new water-based blood pressure cuff

This trial tests a new, very accurate blood pressure cuff that uses water to get a better reading. It is for adults who already need a standard blood pressure cuff and an arterial line as part of their hospital care.

Recovery room care program after surgery

This trial tests whether a specialized “advanced recovery room care” approach can improve outcomes after certain surgeries. It may help patients who need at least one night in the hospital but do not require immediate ICU-level care after surgery.

Tranexamic acid for fewer complications in plastic surgery

This study tests whether applying tranexamic acid directly to the skin during plastic surgery reduces bleeding or other complications compared to a placebo. It may help you heal better after your procedure.

Irrigation solution for spinal surgery instrumentation

This trial tests a solution used to clean the surgical site during spine surgeries to see if it helps prevent infections. It is for patients having certain types of spine surgery for conditions like deformity, cancer, or trauma.