Clinical trials
Tobacco Use clinical trials
Below are recruiting tobacco use clinical trials, each written for real people, not researchers. We’re tracking 103 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06033599RecruitingPhase 3
Mindfulness and motivation to quit smoking while on methadone
This study combines counseling (motivational interviewing) with mindfulness training (like guided exercises) to help people on methadone quit smoking. It tests if adding mindfulness can make it easier to stop smoking and stay quit.
New Brunswick, New JerseyAges 18 years+ - NCT07132814Recruiting
Testing abuse potential of five oral nicotine products
This study tests how much people might want to use five different types of modern oral nicotine products (like pouches or lozenges) compared to smoking their usual cigarette. It helps researchers understand if these products could be less addictive than cigarettes.
Overland Park, KansasAges 21–60 - NCT06239350Recruiting
Young adult tobacco and cannabis co-use study
This study tests a program to help young adults who use both nicotine and cannabis products reduce or quit nicotine use. If you are between 18 and 25, use nicotine products at least 20 days a month and cannabis at least 10 days a month, and want to quit nicotine, you may be eligible.
Charleston, South CarolinaAges 18–25 - NCT06609369RecruitingPhase 2
Sleep and smoking relapse study
This study tests whether improving sleep can help people quit smoking and avoid relapse. It uses brain scans, a quitting medication, and counseling.
New Haven, ConnecticutAges 18–65 - NCT06922617Recruiting
E-cigarettes vs. Nicotine Replacement for Smoking in Substance Use Treatment
This study compares e-cigarettes to nicotine replacement therapy (like patches or gum) to help people who are in treatment for substance use disorder (like drugs or alcohol) quit or reduce smoking. It aims to find a safer way to cut back on cigarettes.
Charleston, South CarolinaAges 21 years+ - NCT05380765Recruiting
Help for First Nation teens to prevent substance use
This trial tests a positive, prevention-focused approach to help North American Indian (First Nation) teens make healthier choices about substance use. It involves both teens and an adult family member who supports good decision-making.
Kingston, Rhode IslandAges 10–14 - NCT06501209Enrolling by invitation
Counseling to help you quit tobacco
This study tests if a special counseling method (called 5A-5R) helps people quit tobacco. If you are an adult who uses tobacco daily and wants to quit, you may be able to join.
DhakaAges 18 years+ - NCT07129590Recruiting
Trauma-informed care to help pregnant people quit smoking
This study tests whether a trauma-informed care approach can help pregnant people who have experienced trauma to quit smoking. The study involves clinicians and patients working together to improve smoking cessation support.
San Francisco, CaliforniaAges 18 years+ - NCT06678672Recruiting
Help for veterans who smoke before major surgery
This study tests a program to help veterans who smoke quit before a planned major surgery. The program uses rewards to encourage quitting, and it may improve surgery outcomes.
San Francisco, CaliforniaAges 18 years+ - NCT06432985Recruiting
Smoking Cessation Program for Veterans with Cancer
This study tests a video-based program to help Veterans who smoke and are being treated for cancer or lung cancer screening to quit. If you're a VA patient in San Francisco and currently smoke, you may be able to join.
San Francisco, CaliforniaAges 18 years+ - NCT06688539RecruitingPhase 4
Quitting e-cigarettes in adults who also use cannabis
This trial tests if varenicline, a stop-smoking medication, can help people ages 18 to 40 quit e-cigarettes while also using cannabis. It's designed for regular e-cigarette users who want to quit and who use cannabis at least 10 days per month.
Charleston, South CarolinaAges 18–40 - NCT05805722Recruiting
Tobacco quit program for cancer patients and recent quitters
This study offers a structured tobacco-cessation program for people with a history of cancer who currently use tobacco or quit recently. It tests approaches to help you stop using tobacco and stay quit while you’re getting care or recovering.
Richmond, VirginiaAges 18 years+ - NCT06372899Recruiting
Switching to E-cigarettes or Nicotine Pouches for Smokers
This study tests whether switching to e-cigarettes or nicotine pouches can help smokers who have tried many times to quit. If you are a heavy smoker (at least 5 cigarettes a day) and have failed to quit before, this trial may offer a new way to reduce harm from smoking.
Philadelphia, PennsylvaniaAges 21 years+ - NCT07712887Recruiting
Studying how IQOS users puff across device models
This study looks at how people who regularly use IQOS inhale from different versions of the device. It aims to understand how the feeling and pattern of use change between models.
Beirut, BeirutAges 18–65 - NCT07501624Enrolling by invitation
Pharmacist-led tobacco treatment for HIV patients
This study works with pharmacists at six Ryan White HIV clinics to help people with HIV quit smoking or using tobacco. If you have HIV, are 21 or older, and have already met with a pharmacist about tobacco, you may be able to join.
Charleston, South CarolinaAges 21 years+ - NCT07501572Enrolling by invitation
Escape room game to prevent tobacco harm for kids
This study tests if a robot-assisted escape room game can help 5th and 6th graders learn about the dangers of tobacco. It may help students make healthier choices.
New Taipei City, Xindian DistrictAges 10–12 - NCT07398443Recruiting
Study of marijuana and tobacco use in young adults
This study looks at how young adults use both marijuana and tobacco, and aims to understand their behaviors. It involves tasks and questionnaires, and may help develop better support for people who use both substances.
Providence, Rhode IslandAges 18–25 - NCT06264154Recruiting
Can e-cigarette flavor help you quit smoking?
This study looks at whether the flavor of an e-cigarette can help people who keep smoking switch completely away from regular cigarettes. Participants will use e-cigarettes with different flavors for 6 weeks.
Philadelphia, PennsylvaniaAges 21 years+ - NCT06862050Recruiting
Testing a smoking cessation program for tobacco users
This trial tests a program to help people quit tobacco. It focuses on offering support to daily tobacco users living in the Augusta or Central Savannah River Area.
Augusta, GeorgiaAges 18 years+ - NCT05852860Enrolling by invitation
Mentoring program for HIV clinicians on tobacco cessation
This study tests a mentoring program to help clinicians who care for HIV patients learn more about helping patients quit smoking. It aims to improve how doctors and nurses support tobacco cessation in HIV care.
Philadelphia, PennsylvaniaAges Any age - NCT07049757Recruiting
Healthy Family Project: Reducing tobacco smoke in Chinese American homes
This study helps Chinese American families reduce tobacco use and secondhand smoke exposure. Smokers, family members, and community health workers are all welcome.
San Francisco, CaliforniaAges 18 years+ - NCT07162935Recruiting
Cigarillo use study for young adults
This study looks at how young adults use cigarillos. You will smoke research cigarillos in a lab and answer questions. The goal is to understand cigarillo use to help with future regulation.
Oklahoma City, OklahomaAges 18–24 - NCT06249984Recruiting
Comparing moist snuff products for adult users in rural areas
This study compares different types of moist snuff to understand how they affect users. It may help find ways to reduce harm for people who use smokeless tobacco.
Columbus, OhioAges 21 years+ - NCT07168629Recruiting
Community health workers help you get lung cancer screening
This trial tests whether a community health worker can help you get a lung cancer screening. If you are at risk for lung cancer and go to certain community health centers, this program may help you get the screening you need.
Springfield, MassachusettsAges 50–80
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Common questions
- Are there clinical trials for tobacco use?
- Yes. Clin2 currently lists 103 recruiting tobacco use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a tobacco use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a tobacco use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.