Clinical trials
Tobacco Use clinical trials
Below are recruiting tobacco use clinical trials, each written for real people, not researchers. We’re tracking 103 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06789692Recruiting
Reducing tobacco use in people with HIV
This study combines a medication to help people stop smoking with a custom mobile app, all within the Swiss HIV Cohort Study. It's designed for people living with HIV who smoke and want to quit.
Basel, BaselAges 18 years+ - NCT06483412Enrolling by invitation
Healthy Futures: A Vaping Intervention for Teens
This study is testing a program called Healthy Futures that schools can use instead of suspending students caught vaping. The trial wants to see if the program helps teens quit vaping.
Palo Alto, CaliforniaAges 14–18 - NCT07721883Recruiting
Social media and tobacco use in teens
This study looks at how social media affects teens' interest in tobacco products like e-cigarettes and vapes. Researchers want to talk with high school students to understand these influences and help prevent tobacco use.
Los Angeles, CaliforniaAges 14–17 - NCT05487807RecruitingPhase 1
Quit-smoking program for people with HIV in Uganda and Zambia
This study tests a tailored quit-smoking (tobacco cessation) program for people living with HIV in Uganda and Zambia. It aims to help you reduce or stop tobacco use in a way that fits your needs and local setting.
KampalaAges 18 years+ - NCT06310187Recruiting
Little cigar study for daily cigarette smokers
This study looks at how certain chemicals from little cigars affect the body. It may help researchers understand health risks. You must be a daily cigarette smoker who has never smoked little cigars.
Hershey, PennsylvaniaAges 21–65 - NCT05746442Recruiting
Interactive quitting messages for Khmer-speaking people with HIV
This trial tests whether interactive, personalized messages can help people who smoke cigarettes quit. It is designed for Khmer-speaking adults living with HIV and aims to support a quit attempt within about two weeks.
Phnom PenhAges 18 years+ - NCT05572671Recruiting
Study brain scans to predict near-term smoking relapse risk
This study uses MRI brain scans and smoking measurements to understand what may predict when someone is about to smoke again. If you qualify, you’ll be asked to avoid nicotine for 12 hours before a lab visit and complete MRI safety screening.
University Park, PennsylvaniaAges 21–65 - NCT05627674Enrolling by invitation
Help improve lung cancer screening and quitting support uptake
This study tests a “precision” approach to help people who are newly eligible for lung cancer screening actually get screened and start smoking-cessation treatment. If it works, it could make screening and quitting help easier to access and more engaging.
St Louis, MissouriAges 18 years+ - NCT05415761Recruiting
Mobile phone support to help you quit smoking in clinic
This study tests different texting/app-based ways to help people quit smoking, especially those who may have less access to care. You may be assigned to one approach and get support through your phone.
Gainesville, FloridaAges 21 years+ - NCT07199517Recruiting
Helping smokers who aren't ready to quit
This study tests whether switching to a less harmful nicotine product (like a nicotine pouch or e-cigarette) can help people who are not ready to quit smoking reduce their health risks. You would be given a sample of a harm reduction product to try, and researchers will check how it affects your smoking habits.
Philadelphia, PennsylvaniaAges 21 years+ - NCT07031024Recruiting
Quit smoking help in the hospital
This trial studies a program to help smokers quit, offered to anyone over 18 who smokes at least one cigarette (or equivalent) a day, regardless of their reason for visiting the hospital or other substance use. If you are a current smoker, you can join to get support for quitting.
Nice, Alpes MaritimesAges 18 years+ - NCT07425119Recruiting
Quit smoking trial for people who smoke a little each day
This study tests a text message program to help people who smoke 1-10 cigarettes most days but not daily quit. It uses cues and reminders sent to your phone to support your quit attempt.
Durham, North CarolinaAges 18 years+ - NCT03713424RecruitingPhase 2
Brain scan study of an antibiotic for drug addiction
This study uses an MRI brain scan to see how taking clavulanic acid affects brain activity related to drug addiction. It may help researchers understand whether this medicine could change how addiction-related cues affect the brain.
Columbia, MissouriAges 18–65 - NCT03948893Recruiting
Behavior program to help you quit nicotine
This study tests a structured counseling/behavior treatment to help people who smoke become nicotine-free. If you’re interested in quitting, you may be asked to complete questionnaires and follow a quit plan as part of the research.
Columbia, MissouriAges 18 years+ - NCT04595422Recruiting
Train quitline staff to reach smokers about lung screening
This trial tests an educational approach delivered through tobacco quitlines to encourage eligible smokers to learn about lung cancer screening. It may help people who have a heavy smoking history get the right information and next steps.
Houston, TexasAges 18 years+ - NCT04722835Recruiting
Study lung immune cells in people at risk for COPD
This study looks at different lung immune cell patterns and how they work in smokers who are not yet diagnosed with COPD or asthma. It may help researchers understand why some people are more likely to develop COPD, which could guide future prevention or early treatments.
San Francisco, CaliforniaAges 40–75 - NCT04903028Recruiting
Brain stimulation to help people quit smoking
This study tests whether a type of brain stimulation (rTMS) can help people stop smoking. It targets brain circuits involved in cravings, aiming to support quitting safely.
Charleston, South CarolinaAges 22–70 - NCT05513872RecruitingPhase 1/Phase 2
Help to quit smoking using nicotine replacement while not quitting yet
This early-stage study tests ways to help adults who currently smoke daily start making progress toward quitting (or changing smoking habits) over the next 6 months. You may use nicotine replacement, and the study checks safety for people who can use it.
Chicago, IllinoisAges 18 years+ - NCT05587361RecruitingPhase 4
Nicotine cue study using propranolol to study craving
This study tests whether a beta-blocking medicine (propranolol) and nicotine patches change how strongly your brain responds to smoking cues. It may help researchers understand what drives cigarette cravings and how to reduce them.
Tulsa, OklahomaAges 21–60 - NCT05642715Recruiting
HIV smoking reduction program with varenicline and online support
This study tests a harm-reduction approach to help people with HIV smoke fewer cigarettes and quit if they want, using an online tobacco program and varenicline (a quit-smoking medicine). You may be placed in one of two different study groups to compare how well the approaches work.
The Bronx, New YorkAges 40–79 - NCT05707871RecruitingEarly Phase 1
Testing how low-nicotine cigarettes affect heart measurements
This early study checks whether very low-nicotine cigarettes change heart-related measurements during a lab visit. It may help researchers understand how lowering nicotine could affect cardiovascular (heart and blood vessel) function.
Winston-Salem, North CarolinaAges 21 years+ - NCT05723588RecruitingPhase 2
TMS brain stimulation to help veterans quit smoking with PTSD
This Phase 2 study tests whether targeted brain stimulation (TMS) can improve smoking quit outcomes in Veterans who also have PTSD. It also uses brain imaging (MRI) to understand what changes in the brain may help people quit.
Durham, North CarolinaAges 18–75 - NCT05726045Recruiting
Sleep-based brain training to help you quit smoking
This study tests a way to improve smoking cessation using special sleep-based brain stimulation and memory support. If it works, it may help you stay committed to quitting by strengthening helpful brain learning during sleep.
Mannheim, Baden-WurttembergAges 18–65 - NCT05766553Recruiting
Virtual reality mindfulness to reduce cigarette cravings
This trial tests whether guided mindfulness meditation in virtual reality can lower cigarette cravings and help people quit smoking. It may help by reducing urges to smoke during stressful moments.
IteuilAges 18–75
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Common questions
- Are there clinical trials for tobacco use?
- Yes. Clin2 currently lists 103 recruiting tobacco use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a tobacco use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a tobacco use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.