Clinical trials
Tobacco Use Cessation clinical trials
Below are recruiting tobacco use cessation clinical trials, each written for real people, not researchers. We’re tracking 105 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06098144RecruitingPhase 4
Smoking cessation program for construction workers
This study tests a program to help construction workers quit smoking. It involves safety managers receiving training to support workers in their quit attempts.
Miami, FloridaAges 18 years+ - NCT06873009Enrolling by invitation
Can therapy help men in prison quit smoking?
This trial tests if cognitive behavioural therapy (a type of talk therapy that changes thinking and habits) can help men in prison stop smoking. It aims to see what works best and for whom.
Paris, Île-de-France RegionAges 18 years+ - NCT06438549Recruiting
Community health workers help pregnant smokers quit
This study tests whether adding a community health worker to your prenatal care team can help pregnant women quit smoking. It's for women who are ready to make a quit plan and are getting care at certain hospitals.
Loma Linda, CaliforniaAges 18 years+ - NCT05415371Enrolling by invitation
Smoking help program for pregnant women in Medicaid
This study tests a smoking-cessation program for pregnant people who smoke while using Medicaid. It may help reduce smoking during pregnancy through structured support calls.
Oklahoma City, OklahomaAges 18–105 - NCT05627674Enrolling by invitation
Help improve lung cancer screening and quitting support uptake
This study tests a “precision” approach to help people who are newly eligible for lung cancer screening actually get screened and start smoking-cessation treatment. If it works, it could make screening and quitting help easier to access and more engaging.
St Louis, MissouriAges 18 years+ - NCT06501209Enrolling by invitation
Counseling to help you quit tobacco
This study tests if a special counseling method (called 5A-5R) helps people quit tobacco. If you are an adult who uses tobacco daily and wants to quit, you may be able to join.
DhakaAges 18 years+ - NCT06851936Recruiting
Help quitting tobacco for cancer survivors and their caregivers
This study tests a program to help people with a history of cancer and their family caregivers quit using tobacco or nicotine products. You may help researchers learn what works best for supporting quitting in this group.
Gainesville, FloridaAges 18 years+ - NCT07031024Recruiting
Quit smoking help in the hospital
This trial studies a program to help smokers quit, offered to anyone over 18 who smokes at least one cigarette (or equivalent) a day, regardless of their reason for visiting the hospital or other substance use. If you are a current smoker, you can join to get support for quitting.
Nice, Alpes MaritimesAges 18 years+ - NCT04865276Recruiting
Quit tobacco with a phone-based support program
This study tests a phone (mHealth) program designed to help people stop using tobacco. You may be assigned to either the program or a comparison group, based on your location and the study plan.
Londrina, ParanáAges 18 years+ - NCT05445804RecruitingPhase 1
Oral cannabidiol (CBD) to help you quit tobacco
This Phase 1 study tests whether taking oral CBD can help people quit tobacco. It also checks safety and helps researchers learn how people respond to the treatment while they practice quitting.
Baltimore, MarylandAges 18–65 - NCT06218056RecruitingPhase 2
CBD for reducing cigarette smoking in a treatment center
This study tests whether a daily dose of cannabidiol (CBD) can help people who smoke at least 5 cigarettes a day cut down or quit. It is for people staying at a treatment center in Los Angeles where cannabis use is not allowed.
North Hollywood, CaliforniaAges 18–65 - NCT06609369RecruitingPhase 2
Sleep and smoking relapse study
This study tests whether improving sleep can help people quit smoking and avoid relapse. It uses brain scans, a quitting medication, and counseling.
New Haven, ConnecticutAges 18–65 - NCT07489443Recruiting
Helping pregnant women reduce tobacco and cannabis use
This study is testing a program to help pregnant women and new mothers cut back on or quit using tobacco and cannabis. It’s designed to see if the program is easy to use and helps improve health for both mom and baby.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06798324RecruitingPhase 4
Brain stimulation plus smoking cessation medication for quitting smoking
This trial tests whether combining brain stimulation (tDCS) with a smoking cessation medication (varenicline) helps people quit smoking. You would attend daily visits for two weeks.
Toronto, OntarioAges 18–85 - NCT06881069Recruiting
Text-based tobacco cessation support for low-income Utahns
This study tests a text-message program to help people who use tobacco quit. It's designed for adults living in low-income areas in Utah who visit certain clinics.
Salt Lake City, UtahAges 18 years+ - NCT06883097Recruiting
Quitting smoking with HIV: A smoking cessation trial
This study tests whether nicotine replacement therapy (like patches or gum) can help people living with HIV quit smoking. You'll be part of a program that supports your quit attempt while you receive care for HIV.
Winston-Salem, North CarolinaAges 18 years+ - NCT06883162RecruitingPhase 3
A study to help people stop smoking tobacco and reduce cannabis use
This study tests whether a medication called varenicline (or a placebo) can help people who use both tobacco and cannabis to quit or cut back. It takes place in South Carolina and lasts 12 weeks.
Charleston, South CarolinaAges 18 years+ - NCT07129590Recruiting
Trauma-informed care to help pregnant people quit smoking
This study tests whether a trauma-informed care approach can help pregnant people who have experienced trauma to quit smoking. The study involves clinicians and patients working together to improve smoking cessation support.
San Francisco, CaliforniaAges 18 years+ - NCT07148232RecruitingPhase 4
Helping people experiencing homelessness quit smoking
This study tests an extended program to help people who are homeless and smoke at least 5 cigarettes a day quit smoking. It provides nicotine replacement therapy (like patches or gum) and support over time.
San Francisco, CaliforniaAges 18 years+ - NCT05805722Recruiting
Tobacco quit program for cancer patients and recent quitters
This study offers a structured tobacco-cessation program for people with a history of cancer who currently use tobacco or quit recently. It tests approaches to help you stop using tobacco and stay quit while you’re getting care or recovering.
Richmond, VirginiaAges 18 years+ - NCT07576595Recruiting
Lung Cancer Screening and Quit-Smoking Support for African Americans
This study helps African American smokers get lung cancer screening and receive support to quit smoking. Researchers will provide guidance and resources tailored to help you stop smoking and catch lung disease early if needed.
New Orleans, LouisianaAges 50–80 - NCT07501624Enrolling by invitation
Pharmacist-led tobacco treatment for HIV patients
This study works with pharmacists at six Ryan White HIV clinics to help people with HIV quit smoking or using tobacco. If you have HIV, are 21 or older, and have already met with a pharmacist about tobacco, you may be able to join.
Charleston, South CarolinaAges 21 years+ - NCT06042361Enrolling by invitation
Making smoke-free housing fairer for residents
This study aims to make smoke-free policies more equitable in affordable housing communities. If you live in one of the six selected properties in Massachusetts, Maryland, or New York, you may be able to participate in a survey or a group discussion.
Boston, MassachusettsAges 18 years+ - NCT05452772RecruitingPhase 2
Psilocybin plus niacin to help quit smoking
This Phase 2 study tests whether a psilocybin “session” with niacin can help people quit smoking. It’s for adults who smoke daily and want to quit but have tried and struggled before.
Birmingham, AlabamaAges 21 years+
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Tobacco Use Cessation trials by city
Studies with a site in or near these metro areas.
Tobacco Use Cessation trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for tobacco use cessation?
- Yes. Clin2 currently lists 105 recruiting tobacco use cessation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a tobacco use cessation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a tobacco use cessation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.