Clinical trials · Minnesota
Treatment Resistant Depression clinical trials in Minnesota
We’re tracking 5 recruiting treatment resistant depression studies with a site in Minnesota — including Phase 2 studies, each written for real people, not researchers.
Recruiting studies in Minnesota
- NCT03887715RecruitingTeam says not enrolling
VNS device for long-term depression that hasn’t improved
This trial studies whether a vagus nerve stimulation (VNS) device can reduce symptoms of treatment-resistant depression. Participants either receive the VNS treatment or a no-stimulation control, to compare safety and effectiveness.
Minneapolis, MinnesotaAges 18 years+ - NCT04124341Recruiting
Brain implant study for severe treatment-resistant depression
This study tests a brain stimulation implant (called PCS) to help people with long-lasting depression that has not improved with many antidepressant treatments. It also uses brain scans and monitoring sessions to better understand how the treatment works and who may benefit.
Minneapolis, MinnesotaAges 22–70 - NCT06423430Recruiting
Deep brain stimulation for treatment-resistant depression (TRANSCEND)
This trial tests a new brain stimulation treatment (deep brain stimulation, or DBS) for people with hard-to-treat depression. It aims to see if targeting a specific brain area can help when other treatments have failed.
Minneapolis, MinnesotaAges 22–70 - NCT06524830RecruitingPhase 2
Testing VLS-01 film for treatment-resistant depression
This trial tests an experimental film placed inside the cheek (VLS-01) against a placebo to see if it helps people whose depression hasn't improved with standard antidepressants. If you have tried at least two antidepressants without success, this study may be an option for you.
Eden Prairie, MinnesotaAges 18–65 - NCT06668571RecruitingPhase 2
Ketamine for treatment-resistant depression
This study tests if intravenous ketamine can help people with treatment-resistant depression who haven't found relief from at least two other treatments. If you qualify, you'll receive ketamine infusions to see if it improves your mood.
Rochester, MinnesotaAges 18–65
Treatment Resistant Depression trials by city in Minnesota
Where these studies are running in Minnesota
Institutions with a site for the recruiting treatment resistant depression studies listed above.
- University of Minnesota · 3 studies
- Mayo Clinic · 2 studies
- Institute for Integrative Therapies
What taking part in a treatment resistant depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Treatment Resistant Depression trials in other states
Common questions
- Are there treatment resistant depression clinical trials in Minnesota?
- Yes. We're currently tracking 5 recruiting treatment resistant depression studies with a site in Minnesota, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a treatment resistant depression study in Minnesota?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Minnesota to take part?
- Not necessarily. These studies have a site in Minnesota, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a treatment resistant depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New treatment resistant depression studies open in Minnesota regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.