VNS device for long-term depression that hasn’t improved
Part of Mental health clinical trials.
This trial studies whether a vagus nerve stimulation (VNS) device can reduce symptoms of treatment-resistant depression. Participants either receive the VNS treatment or a no-stimulation control, to compare safety and effectiveness.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have major depression for at least 2 years or you’ve had at least 4 separate major-depression episodes, including now
- You’ve tried at least 4 different depression treatments at adequate doses for long enough, and they didn’t work
- Your depression is still severe during screening visits within about 45 days before the device is implanted
- Your antidepressant/psychiatry medicines stay the same for at least 4 weeks before implantation
- You have never had certain conditions like psychosis, schizophrenia, or bipolar “rapid cycling”
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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