IV medicine to help people stay stable with advanced heart failure
Part of Heart & circulation clinical trials.
This Phase 3 trial tests an IV medicine (ALP-1) given continuously to help people with advanced heart failure remain clinically stable. You may be eligible if your heart pumping function is quite low and symptoms are severe despite standard treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are over 18 years old
- You have advanced heart failure with reduced pumping (HFrEF) and your last heart scan within 3 months showed LVEF under 30%
- Recent bloodwork shows higher stress hormone levels (NT-proBNP over 1500 or BNP over 300)
- Your symptoms are severe (NYHA class IIIb or IV: shortness of breath or tiredness at rest or with very little activity) for at least 1 month
- Your kidneys are not working well (GFR under 60) and your KCCQ symptom score is under 70
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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