Stem cell transplant for people with Crohn’s who need new options
Part of Digestive system clinical trials.
This trial studies whether an “autologous” stem cell transplant (using your own cells) can improve Crohn’s disease that has not responded to standard treatments. It may help people who have ongoing, hard-to-control Crohn’s even after medicines and/or who have complications that make surgery risky.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You (or your guardian) can understand the study and sign consent
- You are age 10 to 60 when you sign up
- Your Crohn’s is still active or severe (based on Crohn’s symptom/activity scores) and/or you depend on daily steroid medicine you cannot stop
- Your blood test numbers are high enough (platelets and a certain type of white blood cell) and your kidney function is acceptable
- You cannot have active serious infections right before the stem cell and chemotherapy steps
- If you can become pregnant, you must use effective birth control; pregnancy tests must be negative
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests an experimental cell therapy called ATORM-C for people with Crohn's disease who haven't gotten better with standard treatments. The goal is to see if this new treatment can help heal the intestinal ulcers that cause symptoms.
This trial tests whether a fecal transplant (putting healthy bacteria into your gut) combined with dietary changes can help control active Crohn's disease. It is for people who need stronger treatments or have stopped responding to their current therapy.
This early-phase study tests whether a stem cell transplant can improve Crohn’s disease in teens and young adults whose disease is active and not responding to standard medicines. It may help some people who are not doing well despite several prior treatments, but it also involves intensive study procedures and safety checks.
This Phase 2 study tests whether a transplant using your own stem cells can calm active Crohn’s disease that hasn’t improved with standard medicines. It may help some people with ongoing inflammation and symptoms after multiple Crohn’s treatments.
This trial tests whether a stem cell transplant from a partially matched family member or unrelated donor can help people with severe, hard-to-treat Crohn disease, especially when it starts early or has a known genetic cause. The transplant aims to replace the immune system to stop the disease from attacking the gut.
This trial tests whether a type of stem cell called HB-adMSCs can help treat Crohn's disease. It is for adults with mild to moderate Crohn's who have certain signs of inflammation in their blood and recent imaging of their condition.
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