Stem cell transplant for severe Crohn's disease with genetic link
Treatments studied
Part of Digestive system clinical trials.
This trial tests whether a stem cell transplant from a partially-matched family or unrelated donor can help treat severe Crohn's disease that has a known or suspected genetic cause or does not get better with standard treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have Crohn's disease that is severe or has a known genetic cause.
- Your disease must not have responded well to at least two different types of medications, or you had serious side effects from them.
- You need to be between 2 and 30 years old.
- You must have a donor who matches at least partly on key genetic markers (HLA typing).
- You must be in fairly good health overall, with a performance score of 50 or higher on the Lansky or Karnofsky scale.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This early-phase study tests whether a stem cell transplant can improve Crohn’s disease in teens and young adults whose disease is active and not responding to standard medicines. It may help some people who are not doing well despite several prior treatments, but it also involves intensive study procedures and safety checks.
This Phase 2 study tests whether a transplant using your own stem cells can calm active Crohn’s disease that hasn’t improved with standard medicines. It may help some people with ongoing inflammation and symptoms after multiple Crohn’s treatments.
This trial tests whether injecting donated stem cells into complex anal fistulas can help heal them in people with Crohn's disease. You may qualify if you have a fistula that hasn't improved with standard treatments.
This trial studies a special donor stem cell transplant where the donor’s immune cells are reduced, aiming to lower harmful immune attacks after transplant. It may help children and young adults with certain high-risk blood cancers or rare bone marrow disorders.
This trial studies whether an “autologous” stem cell transplant (using your own cells) can improve Crohn’s disease that has not responded to standard treatments. It may help people who have ongoing, hard-to-control Crohn’s even after medicines and/or who have complications that make surgery risky.
This trial tests whether a type of stem cell called HB-adMSCs can help treat Crohn's disease. It is for adults with mild to moderate Crohn's who have certain signs of inflammation in their blood and recent imaging of their condition.
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