Stem cell transplant for severe early-onset Crohn disease
Treatments studied
Part of Digestive system clinical trials.
This trial tests whether a stem cell transplant from a partially matched family member or unrelated donor can help people with severe, hard-to-treat Crohn disease, especially when it starts early or has a known genetic cause. The transplant aims to replace the immune system to stop the disease from attacking the gut.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 2 and 30 years old.
- You must have a diagnosis of Crohn disease that is severe and has not improved with at least two different biologic or small molecule treatments.
- Your Crohn disease must be caused by a known genetic mutation or show signs of a strong genetic link (such as early diagnosis before age 6, a family history, or certain severe symptoms).
- You must have a donor (family member or unrelated) who is partially matched in blood and tissue type (called HLA).
- You must be generally healthy enough for a transplant, with no severe liver, kidney, heart, or other diseases, and no active infections like HIV or hepatitis.
- You must not have had radiation therapy or a previous stem cell transplant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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