Clin2
NCT00823563Possibly a fitRecruiting

Testing heart artery causes of pain without major blockage

Chest PainIschemia

Part of Pain clinical trials.

This study looks at people who are being checked for possible heart artery–related chest or similar discomfort, but without major artery blockage (non-obstructive arteries). It aims to help doctors understand what might be causing symptoms and guide safer testing.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
2,000 people
Ages
18 years and older
Study type
Observational

Who can take part

  • You have been referred for an elective heart angiogram because doctors suspect reduced blood flow to the heart
  • You have symptoms like angina (chest pain or pressure) or similar discomfort with activity or emotional stress, or at certain times
  • You are not having an emergency heart problem right now (like STEMI/NSTEMI) and you’re not in shock
  • You’re not scheduled mainly as an “asymptomatic” pre-procedure check, and you haven’t had a heart transplant
  • Your kidneys are functioning adequately (creatinine is not above 1.5)
  • You can give informed consent, and you can communicate for the consent process in the allowed languages

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06424834Recruiting· Phase 2/Phase 3
Targeted medicines for chest pain without blocked arteries

This study tests if specific heart medicines (like beta-blockers or calcium channel blockers) can help people with chest pain that is not caused by blocked arteries. It aims to treat the tiny blood vessels or spasms that may be the real cause of your pain.

Palo Alto, California
NCT06896903Recruiting
Testing heart artery function with and without nitroglycerin

This study compares two ways of testing the small blood vessels in the heart to understand chest pain when no major blockages are found. It may help doctors learn more about why you have chest pain and how to treat it.

Plano, Texas
NCT00573027Recruiting
Study of heart pain from small artery heart disease

This trial studies people who have chest pain (angina) due to problems with the heart’s small arteries, not a big blockage. It aims to test whether treatment approaches can help these patients by better understanding the cause of their heart-related symptoms.

Los Angeles, California
NCT07422818Not yet recruiting
Non-invasive testing for chest pain without blocked arteries

This study tests a non-invasive method to evaluate chest pain in people who do not have blocked coronary arteries. It may help patients understand the cause of their symptoms without needing invasive procedures.

NCT07337005Not yet recruiting
Heart artery function test for chest pain

This study tests a new way to measure small blood vessel function in people with chest pain but clear main arteries. It aims to find hidden causes of discomfort so doctors can choose the right treatment.

NCT06400290Recruiting
Balloon test to find which artery causes chest pain

This study tests a new way to find which blocked heart arteries are causing your chest pain. During a stent procedure, doctors will briefly block each artery to see which one triggers your symptoms. This might help them decide which blockages to treat.

Basildon

Hear when a new Chest Pain trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.