Brain scan and ketamine study for suicidal thoughts
Treatments studied
Part of Mental health clinical trials.
This trial studies how ketamine affects the brain in people dealing with suicidal thoughts or an active suicide crisis. It uses questionnaires, consent testing, and brain imaging to look for biological changes that may relate to symptom improvement.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be between 18 and 70 years old
- Be able to understand the study and pass consent understanding checks (high quiz scores)
- If you can become pregnant, agree to avoid pregnancy (abstinence) or use effective birth control during each study phase
- For later phases (Phase II and III), you must complete the earlier study phase and report at least mild suicidal thoughts or related symptoms
- You must be able to do MRI brain scans (no unsafe metal implants and you must tolerate being in the scanner)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This early-stage study tests how ketamine given once and then repeatedly may change brain signals and related biomarkers in people with major depression. If you’re eligible, the team will use brain imaging and assessments to see who responds and why.
This early-stage study tests ketamine and looks at what brain changes may explain why it helps people with major depression that hasn’t improved with usual treatments. You may be asked to stay in the hospital and complete detailed interviews, mood rating scales, and brain imaging.
This trial tests if a single dose of ketamine can quickly reduce suicidal thoughts in people who come to the emergency department. If you are having active suicidal thoughts and need inpatient care, you may be able to join.
This trial tests whether a single dose of ketamine can quickly improve depression by studying brain chemical changes using MRI. It's for people with treatment-resistant depression who haven't used ketamine before.
This study tests how ketamine affects brain chemicals linked to suicidal thoughts in people with depression. You will receive ketamine and have brain scans (PET and MRI) to see if it changes activity in opioid receptors.
This study tests if ketamine can help reduce suicidal thoughts in people with major depression. You'll receive ketamine treatment and be monitored closely.
Hear when a new Depression trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.