Ketamine plus brain imaging to study response in depression
Treatments studied
Part of Mental health clinical trials.
This early-stage study tests how ketamine given once and then repeatedly may change brain signals and related biomarkers in people with major depression. If you’re eligible, the team will use brain imaging and assessments to see who responds and why.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 to 65 years old.
- You must understand the study and sign consent.
- You must agree to stay in the hospital for the study.
- If you’re joining for the depression part: you must have major depression for at least 2 weeks.
- If you’re joining for the depression part: your depression and mood ratings must match specific ranges at baseline.
- You must not have certain conditions or recent medication/substance use that could make ketamine or scans unsafe.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This early-phase study tests whether ketamine can help people with major depression who have trouble feeling pleasure. It also studies how the brain may change in response to stress, to better understand who might respond to treatment.
This trial studies how ketamine affects brain circuits in people with depression compared to healthy volunteers. It involves a single infusion of ketamine and brain scans before and after.
This study uses a special headband (TD-fNIRS) that measures brain activity to see if it can predict how well different depression treatments work. You would be starting a new treatment for depression (like ketamine, SPRAVATO, TMS, or antidepressants) and wear the headband before and during treatment.
This study compares ketamine alone to ketamine combined with psychotherapy for treating depression. It may help if you have moderate to severe depression and want to see if adding talk therapy improves results.
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