Methotrexate or leflunomide plus added therapy for rheumatoid arthritis
Part of Bones, joints & muscles, Immune system & allergy, Skin clinical trials.
This study compares two combination treatments for rheumatoid arthritis in people whose current methotrexate or leflunomide isn’t working well enough. It aims to see whether adding a targeted therapy works better than the standard add-on of sulfasalazine plus hydroxychloroquine.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have rheumatoid arthritis (RA), confirmed by established RA diagnosis rules
- Your RA is still active: your DAS28-CRP score is higher than 3.2
- You tried methotrexate (at least 15 mg weekly for 3+ months) or leflunomide (10–20 mg/day for 3+ months) and it did not work well enough
- Your test results or scans suggest RA is affecting your joints (for example, erosions and/or positive anti-CCP or rheumatoid factor)
- You’re 18 or older and can sign consent before any study steps
- If you could become pregnant, you must have a negative pregnancy test and use reliable birth control during the study and for a period after
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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